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Sickle Cell Anemia using Nicholas’ Story
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25 Jun 2020 | Contributor(s): Sharon Cisneros | doi:10.25334/Z773-JS90
The goal of this exercise is to introduce students to 3-D structures of biological molecules, visualize and manipulate them to understand their functions. The exercise also helps them see the effect of changing an amino acid.
The Happy Blue Baby Hemoglobin
14 Jun 2020 | Contributor(s): Kasandra Jean-Louise Riley, Shuchismita Dutta | doi:10.25334/N5JP-1P96
This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved.
COVID-19: Molecular Basis of Infection
12 Jun 2020 | Contributor(s): Didem Vardar-Ulu, Shuchismita Dutta | doi:10.25334/HQCA-QD59
This case was written in Spring 2020 during the COVID-19 pandemic. It focuses on understanding the structure and interaction of the SARS-Cov-2 viral spike protein that facilitates infection in human cells.
A Case of Severe Insulin Resistance
12 Jun 2020 | Contributor(s): Melanie Lenahan, Shuchismita Dutta | doi:10.25334/DTTA-WW18
This case focuses on understanding how a mutation in a cell signalling protein (a kinase) can prevent insulin function and lead to diabetes.
12 Jun 2020 | Contributor(s): Laurel Lorenz, Shuchismita Dutta | doi:10.25334/ZM3H-4149
This case focuses on understanding structure and function relationships in Piwi, a protein that is critical for germline stem cell function and development of eggs in the fruit fly ovary.
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