About
We developed a new molecular case study to introduce students to directed evolution of enzymes, aiming to deepen their understanding of what differentiates an enzyme from all proteins. The case study focuses on heme proteins where students learn to visualize and explore the structure of myoglobin and how making changes in a few amino acids can convert an oxygen transporter protein into an enzyme, that can catalyze the formation of a covalent bond. We piloted a draft version of the case study in class to promote a deeper appreciation for molecular biology concepts. Feedback from neurodivergent students informed iterative improvements, ensuring inclusivity and accessibility. We utilized 3D printed models alongside the Mol* molecular visualization platform enhances student comprehension by providing tangible representations and interactive digital exploration. Involving students in developing the case study promotes active engagement and fosters a sense of ownership in their learning. Moreover, the case study empowers students to utilize Mol* beyond a single case study, promoting independent exploration and reinforcing learning outcomes.