Understanding COVID-19 Biology to Design a Vaccine
Author(s): Keith Johnson1, Didem Vardar-Ulu2, Shuchismita Dutta3
1. Bradley University College of Liberal Arts and Sciences 2. Boston University 3. RCSB Protein Data Bank, Rutgers University
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- Johnson et al COVID-19 answer key-6180.docx(DOCX | 32 KB)
- Johnson et al COVID-19 resources.docx(DOCX | 16 KB)
- Johnson et al COVID-19 teaching notes.docx(DOCX | 20 KB)
- Johnson et al COVID-19 worksheet 1.docx(DOCX | 744 KB)
- Johnson et al COVID-19 worksheet 2.docx(DOCX | 6 MB)
- Johnson et al COVID-19 worksheet 3.docx(DOCX | 416 KB)
- Johnson et al COVID-19 worksheet 4.docx(DOCX | 1 MB)
- Johnson et al COVID-19 worksheet 5 assessment.docx(DOCX | 18 KB)
- Johnson et al Worksheet 2 ethics supplement.docx(DOCX | 19 KB)
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Description
The case presented here is written during the COVID-19 pandemic (Spring 2020) and uses this backdrop to introduce students to the initial stages of developing a vaccine against the SARS-CoV-2 virus, targeting its spike protein. The viral protein binds to a specific human protein on human epithelial cells and this initiates the infection. The structure of the viral spike and human receptor protein interaction was determined using cryo-electron microscopy by Yan et al (2020). Using the freely available molecular structural data and publicly available visualization software and bioinformatics tools and resources, the case leads students to examine the interaction of the viral spike (S) protein with the human epithelial cell ACE-2 protein, the site of viral attachment. The vaccine development discussed in this case is focused on blocking this interaction to stop infection.
Painting depicting coronavirus. (Acknowledgement: Illustration by David S. Goodsell, RCSB Protein Data Bank; doi: 10.2210/rcsb_pdb/goodsell-gallery-019.)
Cite this work
Researchers should cite this work as follows:
- Johnson, K. A., Vardar-Ulu, D., Dutta, S. (2020). Understanding COVID-19 Biology to Design a Vaccine. Molecular CaseNet Faculty Mentoring Network Spring 2020, QUBES Educational Resources. doi:10.25334/DNC7-8581