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Module 3: Transcription, Part II: What Happens to the Initial Transcript Made by RNA pol II?

Author(s): Cathy Silver Key1, Chiyedza Small2, Laura Reed3

1. North Carolina Central University 2. Medgar Evers College CUNY 3. The University of Alabama

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Summary:
This module teaches about the three key steps that are involved in converting the pre-mRNA into a mature mRNA: 1) The addition of a 5’ cap, 2) The addition of a 3’ poly(A) tail, 3) The removal of introns through splicing.

Licensed under CC Attribution-ShareAlike 4.0 International according to these terms

Version 1.0 - published on 25 Jul 2020 doi:10.25334/PYZN-JQ45 - cite this

Keywords

  1. genetics
  2. molecular biology
  3. Genome Browser
  4. genomics
  5. splicing
  6. mRNA
  7. cDNA
  8. 5' Cap
  9. 3' Poly(A) Tail
  10. RNA Maturation

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Description

This module demonstrates how the transcript generated by RNA polymerase II (the pre-mRNA) is processed to become mature mRNA using the sequence signals identified in Module 2. After completing this module, students will be able to use the genome browser to explain the relationships among pre-mRNA, 5' capping, 3' polyadenylation, splicing, and mRNA. The specific nucleotide sequences that guide the maturation process are highlighted. Students will observe that introns are removed during this process and adjacent exons are brought together in the mRNA message.

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