This case focuses on understanding the molecular basis of Anna's sleeping disorder and its treatment. The adaptations addressed question clarity and reformatting to use Mol*.
Listed in Teaching Materials
Adapted from: Waking up Anna v 1.0
Overview: This case discusses Anna's sleeping disorder, a condition that was disrupting her normal life. The case begins by watching a video where Anna and her doctors describe her story. When most of the standard treatment approaches for treating her condition had failed, researchers examined her cerebrospinal fluid and found a substance in it that was acting like a sleeping pill! Understanding the molecular basis for where and how this substance was acting helped doctors develop a treatment for Anna. The case explores the structure function relationships of receptor molecules in the brain targeted by the treatment. It also examines how the binding of other small molecule drugs can impact the function of this receptor target.
Learning Objectives: The case was developed at the interface of biologyy and chemistry for introductory biology courses for undergraduate students to become familiar with scientific literature, learn to use data from various bioinformatics resources, and have a chance to explore chemical interactions that stabilize the structure and/or enable the functions of complex biological molecules. Depending on the details included in the discussions, it may also be used to teach slightly advanced physiology, cell biology, and neuroscience students. By the end of the case, students should develop some basic understanding of biomolecular structure-function relationships.
Molecules explored: The primary molecule explored in this case is the GABA-A receptor, that forms part of an ion channel. Different forms of the receptor, either alone or in complex with various small molecular ligands and/or drugs are explored to understand structure-function relationships in regulating opening and closure of the ion channels.
Implementation: The case can be implemented using either a flipped approach and/or through in-class discussions.
- GABA-Anna.png(PNG | 199 KB)
- Waking Anna teaching adaptations.docx(DOCX | 14 KB)
- Waking Up Anna 2021 Part 1 key.docx(DOCX | 288 KB)
- Waking Up Anna 2021 Part 1 student.docx(DOCX | 289 KB)
- Waking Up Anna 2021 Part 2 key.docx(DOCX | 261 KB)
- Waking Up Anna 2021 Part 2 student.docx(DOCX | 262 KB)
- Waking Up Anna 2021 Part 3 key.docx(DOCX | 2 MB)
- Waking Up Anna 2021 Part 3 student.docx(DOCX | 924 KB)
- Waking Up Anna 2021 Part 4 key.docx(DOCX | 1 MB)
- Waking Up Anna 2021 Part 4 student.docx(DOCX | 109 KB)
- Waking Up Anna 2021 Part 5 key.docx(DOCX | 582 KB)
- Waking Up Anna 2021 Part 5 student.docx(DOCX | 107 KB)
- Waking Up Anna 2021 Part 6 key.docx(DOCX | 440 KB)
- Waking Up Anna 2021 Part 6 student.docx(DOCX | 101 KB)
- Waking Up Anna 2021 Part 7 key.docx(DOCX | 100 KB)
- Waking Up Anna 2021 Part 7 student.docx(DOCX | 98 KB)
- Waking up Anna
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Cite this work
Researchers should cite this work as follows:
- Johnson, K. A. (2021). Waking up Anna - Adaptations and Conversion to Mol*. QUBES Educational Resources. doi:10.25334/T9X9-K122
This adaptation reformatted some questions, broke the case into smaller parts (point values are provided), and converted the case to use Mol*, which is now part of RCSB or a stand alone version.