The national conversation on the mental health, resilience, and well-being of graduate students has escalated across the higher education landscape. Within STEM disciplines, competition, power-differentials and the importance of the advisee-advisor relationships are added to the stressors of field and bench research. Within this back-drop, the expanding diversity of STEM graduate students promises new perspectives and ideas that can accelerate research progress, but only if graduate schools improve inclusivity to foster an environment where students thrive, complete their degrees, and are positioned to not only join the professional STEM community but to assume leadership of it. Mental Health Opportunities for Professional Empowerment in STEM (HOPES) is a three-university collaboration consisting of Montana Technological University, Montana State University Billings, and the University of Montana HOPES will design, pilot, assess, and implement evidence-based, sustainable and replicable strategies to facilitate and enhance graduate-student mental health. Student experiences will be designed, piloted, and evaluated to equip and empower diverse graduate students—across the full range