The COVID-19 pandemic has undoubtedly impacted everyone around the globe. In 2020, many countries entered into a lockdown, transforming daily lifestyles into isolation. The SARS-CoV-2 virus that causes the disease COVID-19 slowly spread to different regions of the world, and the first cases of COVID-19 infection in Los Angeles County, California, were documented in mid-January 2020. In March 2020, Governor Gavin Newsom of California declared a state of emergency and implemented a stay-at-home order (1). Therefore, people were quarantined at home, and many “non- essential” businesses were closed, including schools. With no cure available and hospitals reaching maximum capacity, scientists raced to develop vaccines to immunize individuals against the virus. Meanwhile, wastewater technicians began collecting wastewater samples to monitor the presence of the SARS-CoV-2 virus shed from infected residents. We hypothesized that the presence of SARS-CoV-2 RNA in LA County wastewater would decrease as localized vaccination rates increased. Here, we describe a meta-analysis comparing two data sets; the vaccination progression data in Los Angeles County, and the wastewater surveillance PCR