We believe that a biology-relevant calculus experience (biocalculus) can help overcome many of these issues in calculus. While challenging to build the capacity for teaching courses, students in biocalculus articulate more detailed connections to the theory of their disciplines and find it more relevant. Biocalculus leverages students' passion and knowledge about biology, and students who enroll in biocalculus courses have greater learning gains than students in traditional calculus courses and lower fail and drop rates. Finally, as biocalculus moves to be more relevant in an age of big data and computing, we explore the epistemological consequences of this shift in the last decade.