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    GEA Introductory lesson on BLAST
    The "Introduction to BLAST using Human Leptin" exercise aims to introduce students to the use of the Basic Local Alignment Search Tool (BLAST) to identify related sequences and compare similarity...

    Keywords: geneticsProbabilitydatabasebioinformaticsphylogenetic analysisgenomicsBLASTProtein sequenceSimilarity searches

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    Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson
    There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has...

    Keywords: bioinformaticscancertranscriptomicshigh-throughputData wranglingSingle cell RNA sequencingq

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    Sequence Similarity Resource Adaptation: Exploring Ebola Virus
    This adaptation of the sequence similarity resource provides biology students with a basic set of bioinformatics concepts and tools. These concepts and tools are used to explore relationships...

    Keywords: phylogeneticsbioinformaticsEbolasequencingFASTANCBINIBLSEalgorithmsincubatorsBLASTmultiple sequence alignmentsequence similarityBLOSUM scoring matrixneighbor-joining distance matrixCourseSourcephylogram

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    A 360˚ View of COVID-19
    In March 2020, institutions underwent a massive transition to distance learning as a result of the COVID-19 pandemic. With so little time to devise new materials to maximize learning in the new...

    Keywords: geneticsImmunologyBiochemistrybioinformaticsmolecular evolutionpublic healthvirusCOVID19

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    Understanding Restriction Enzyme Digests
    Prior to submitting genomic DNA for sequencing, SEA students perform a restriction endonuclease digest with several enzymes, which provides a fast and cost-effective way of quickly screening...
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    Learning About Protein Localization: A Lesson for Analyzing Figures in a Scientific Publication
    In order to function correctly, proteins must be localized to a specific subcellular location. We have designed this lesson to use data from the primary literature to teach students about the...

    Keywords: colocalizationimmunofluorescenceProtein localizationsignal sequencessubcellular fractionationwestern blotting

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    5-010-DNADegradation-ModelingScenario
    We ask students to use the system of first order linear differential equations given in a source paper and estimates of the data from laboratory procedures from a plot to estimate the parameters...

    Keywords: DNA\kinetisplasmaratpharmacokinetis

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    Introduction to Genome Browser: What is a Gene?
    In this module, we will use a web-based visualization tool called a Genome Browser to explore the structure of a eukaryotic gene, and obtain a basic understanding of how this information is...
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    Translating Co-Translational Translocation
    Understanding the process of proteins targeting to specific locations within a cell is a fundamental part of cell biology. Synthesis of proteins by co-translational translocation, which also...

    Keywords: Topologyco-translational translocationendoplasmic reticulumprotease protection assaysecretory proteinssignal sequencetransmembrane proteins

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    Studying phylogeny by producing phylogenetic trees of primates using morphological and molecular characteristics.
    An assignment constructing phylogenetic trees using shared, derived morphological traits and molecular differences among 18 primate species and two outlier species has been developed. Skull and...
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    Genome Sequence Data in R using Biostrings (Swirl Lesson)
    By the end of this lesson, students should be able to load FASTA files into R as DNAStringSets and use width() and alphabetFrequency(), combined with other functions like sum() and mean(), to...

    Keywords: R programming languagecourse-based undergraduate research experienceBioinformatics and GenomicsCURECUREscourse-based research experiences (CUREs)STEM CUREsComparative genomicsBioconductor

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    Targeting Misconceptions in the Central Dogma by Examining Viral Infection
    Understanding the central dogma and how changes in gene expression can impact cell function requires integration of several topics in molecular biology. Students often do not make the necessary...

    Keywords: datatranscriptionvirustranslationprotein functionmembrane transportPredictions

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    2017-William_Bialek-Boxes and Arrows To Differential Equations
    This material uses pictures to build kinetic models of reactions and then offers analytic solutions.

    Keywords: Michaelis-MentenEnzymesubstrateDNA\kinetis

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    A Curious Display
    Case study on genetically modified organisms provided in English and American Sign Language.

    Keywords: geneticscase studyagricultureBiotechnologyenvironmental scienceDNAUniversal Design for LearningGMOAmerican Sign Language

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    Hemoglobin bioinformatics
    This is an introduction to bioinformatics using hemoglobin as an example. The worksheets introduce students to resources to explore the DNA, RNA and polypeptide linear structure with a brief...

    Keywords: bioinformaticsHemoglobinBLASTsickle cell diseaseMolecular Case StudyClustal OmegaMolCaseNet

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    The Ames Test
    Introduction to the Ames Test, published as GSA Learning Resource

    Keywords: geneticsNIBLSEDNAames testassay

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    Team microBIOME Fall 2020 - DIY microbiome analysis
    This is our final team report for this year's BIOME Institute 2020. Learn about what we got up to and what we're planning for Spring 2021. If you want more information on REMNet go...

    Keywords: microbiomeDNA SubwayDIYREMNet microbiomesNephele

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    Module 4: Removal of Introns from pre-mRNA by Splicing
    In this module, students will learn to identify splice donor and acceptor sites that are best supported by RNA-Seq data, and use the canonical splice donor and splice acceptor sequences to identify...

    Keywords: geneticsdata visualizationmolecular biologygenomicsexonintronsplicingSimilarity searchesRNA Maturation

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    Origin and Diversity of Armor in Girdled Lizards
    The girdled lizards (Cordylidae) are a family of distinctively armored lizards endemic to Sub-Saharan Africa. Students examine lizards in this family to classify the lizards based on morphological...

    Keywords: Evolutionphylogenetic analysisHerpetologynatural history collections3D modelsVertebrate MorphologyCT scanoVertConvergent Evolution

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    Introduction to Genome Annotation
    This exercise is an adaptation of the Annotation Lesson by Rosenwald et al. It introduces the use of bioinformatics tools to extract information from genome databases. It is a basic lesson on...

    Keywords: microbiologyGenome annotationBioinformatics EducationBioinformatics and Genomics

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