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    The p53 Gene and Cancer
    This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer.

    Keywords: Resources @ HHMI - BioInteractiveBiochemistrymolecular biologymacromoleculesGenetic disease

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    Doubling Time of Tumors
    This module introduces the calculation of potential doubling time of tumorous cells in the context of understanding the growth of a population of the cells. It is intended for an introductory...

    Keywords: linear regressionRatiosCell StructureOpenStaxCell Growth

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    Open science, open data, open source projects for undergraduate research experiences
    Resource from the 2015 BioQUEST Summer Workshop
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    Cancer Discovery Activities
    These two hands-on activities are based on a Howard Hughes Medical Institute 2013 Holiday Lectures on Science video (http://www.hhmi.org/biointeractive/cancer-genetic-disease-video-highlights)...

    Keywords: geneticsResources @ HHMI - BioInteractiveorganismal biologyneurosciencegenomicscancergenetic basis of diseasebiology of cellsHigh School

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    Teaching Advanced Concepts in Regulation of the Lac Operon With Modeling and Simulation
    Success in biochemistry and other life science courses requires that students understand important biological concepts. One of these concepts is how gene regulation ensures that homeostasis is...

    Keywords: gene regulationinducible operonProkaryotic cellPhosphoenolpyruvate transferase system (PTS)

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    A simple way for students to visualize cellular respiration: adapting the board game MousetrapTM to model complexity
    Lecture-based introductory biology courses are typically content-heavy as instructors strive to provide students with foundational knowledge in a broad range of topics.  One topic...

    Keywords: ATPGlycolysisCellular RespirationElectron Transport ChainKrebs Cycle

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    Dilution and Pipetting Lesson Using Food Dyes
    In this lesson students learn how to use micropipettors to accurately measure small volumes of liquids and perform dilutions using food dyes. Students dilute four food dyes at 10X concentration to...

    Keywords: dilutionCalculationLab SkillsMicropipetting

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    Drawing flowcharts of lab protocols helps students prepare for biology labs
    With the publishing of the Vision and Change report, we know it is best practice to include authentic research experiences in our undergraduate science lab classes. One big challenge in teaching...

    Keywords: laboratorymolecular biologyUndergraduateprotocolflowchart

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    Go Extinct! An Award-Winning Evolution Game That Teaches Tree-Thinking as Students Pursue the Winning Strategy
    Evolutionary trees communicate both the diversity and unity of life, a central and important scientific concept, as highlighted by the Vision and Change undergraduate biology education movement....

    Keywords: phylogeneticsnatural historyBiodiversitycladogramCommon ancestorEvolutionary treeLand vertebratesMonophyletic cladeTetrapods

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    1998-Elly_Claus-McGahan-Modeling Projects in a Differential Equations Course
    Here we discuss the value of student designed, in-depth, modeling projects in a differential equations course and how to prepare them for it.

    Keywords: projectswritingpopulationtankmixingcomputer-aided analysissprinting

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    1-039-StochasticPopModels-ModelingScenario
    We develop strategies for creating a population model using some simple probabilistic assumptions. These assumptions lead to a system of differential equations for the probability that a system is...

    Keywords: Probabilitypopulation dynamicsVarianceMeanstochasticdeterministic

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    The Human Microbiome Biodiversity in Health and Disease
    The students will analyze the human gut and vaginal microbiomes in healthy and diseased states using diversity of bacteria as determined by 16SrRNA sequence.
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    Digital Laboratory Framework via Canvas for LIFE courses at Colorado State University
    The Life Lab Revisions team has piloted a Canvas-based approach to building scientific competencies in labs.

    Keywords: online learningvirtual lab

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    Module 3: Transcription, Part II: What Happens to the Initial Transcript Made by RNA pol II?
    This module teaches about the three key steps that are involved in converting the pre-mRNA into a mature mRNA: 1) The addition of a 5’ cap, 2) The addition of a 3’ poly(A) tail, 3) The removal of...

    Keywords: geneticsmolecular biologyGenome BrowsergenomicssplicingmRNAcDNA5' Cap3' Poly(A) TailRNA Maturation

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    Genome Solver: Building faculty skills in bioinformatics
    Genome Solver (GS) began in 2011 as an NSF-funded project for faculty training in basic web-based bioinformatics skills.

    Keywords: faculty developmentbioinformaticsgenome solver

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    Integration of Bioinformatics into Life Science Curricula: Community Development, Dissemination, and Assessment of a NIBLSE Learning Resource
    Big data and computational tools have transformed the way we address biological questions. To prepare undergraduates for tomorrow’s challenges, life science curricula should integrate the...

    Keywords: bioinformaticsNIBLSELife Science

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    Drugging SARS-CoV-2
    This case study leads students through the process of proposing a drug for a novel protein. The Mpro protease of SARS-CoV-2 is explored in detail within the PDB. Aligns with first semester...

    Keywords: viruscoronavirusPDBSARS-CoV-2proteasedrug design

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    Exploring the Introduction of Genetic Variation by Random Mutation: Avida-Ed Lab Book Exercise 1
    An introductory activity introducing the role of random mutation in generating genetic variation using the Avida-ED simulation.

    Keywords: geneticsEvolutionavida-edmutationsoftware simulations

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    Evidence of Evolution Homologous Structures
    Using CT (Computed Tomography) scans of vertebrate forelimbs, both as 3D models and as shapefiles, to enhance and illustrate the concepts of homologous structures, and the evolution of anatomical...

    Keywords: EvolutionidigbioZoology3D modelsanatomy and physiologyMiddle SchoolVertebrate MorphologyCT scanoVerthomologous structures

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    Louse Genetics, Genomics, and Gene Function...Oh My!
    In this module, students will be investigating a louse gene with an unknown function to determine if it might be important in the evolution of the louse ecomorphs.

    Keywords: parasitesgenomicsgene sequence analysisFunctional Genomics

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