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    Metastatic Mastery: A Case and Game-Based Approach to Learning About Cancer Mechanisms
    Mechanisms that contribute to the development of cancer are numerous and complicated, though most can be traced to a set of mutations in cell cycle regulatory genes that throw the process of cell...

    Keywords: mutationcancertranscriptioncell cycletranslationOncogenesTumor-suppressorp53Transcription factor

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    Enzyme Kinetics: How Quickly Can Acetylcholinesterase Break Up Your Thoughts?
    This module contains exercises designed to help upper-level cell biology students understand the common graphical methods used to evaluate enzyme activity and to see the impact of inhibitors on...

    Keywords: cell biologyQuantitative reasoninginterdisciplinarylinear modelsInterpreting GraphsNIQBC2. Data and GraphsC4. mathematical modelsnonlinear models

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    Inexpensive Cell Migration Inquiry Lab using Zebrafish
    Cell migration is an important and interesting topic that has the potential to engage students in cell biology by its intrinsically active nature. However, most ways to investigate cell migration...

    Keywords: CytoskeletonCell migrationmodel organisms

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    Sickle Cell Disease Case Study
    A short film explores the evolutionary connection between an infectious disease, malaria, and a genetic condition, sickle cell anemia. The animation explores the genetic causes and biological...

    Keywords: HHMI BioInteractive

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    Maternal transmission of microbiome
    Understanding the cascading effects of the transfer of maternal microbiome during a vaginal birth (vs. a c-section) to the well-being of a newborn.

    Keywords: microbiomehuman reproduction

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    Using a Primary Cell Culture Model to Study the Neural Extracellular Matrix
    The extracellular matrix (ECM) provides structural support to cells, but also has key roles in mediating cell adhesion, cell signaling, and differentiation. While this topic is discussed in the...

    Keywords: Neural extracellular matrixPerineuronal netPrimary neuronal culture

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    Understanding the Importance of Microtubules in Normal Cell Division: Chemotherapy Connection
    In introductory courses, students learn about microtubules as important structures but may not engage in a hands-on experience to localize microtubules themselves or to learn about their connection...

    Keywords: cancerCell DivisionimmunofluorescenceMicrotubulesAntibodies

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    Necessary and Sufficient? Solving the Mystery of the Mitochondrial Pyruvate Transporter
    While there are several available lessons for teaching introductory biology students about diffusion, facilitated diffusion, and active transport, fewer materials exist to support upper-division...

    Keywords: DiffusionActive transportfacilitated diffusionNecessary and sufficientTransport proteins

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    Sequence Similarity in Developmental Biology - A Bioinformatics Exercise Using Myostatin
    This exercise leads upper level biology majors in an inquiry-based excursion to determine how similar the signaling molecule, myostatin, is between humans and mice, using a basic set of...
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    CBEC - Cell Biology Education Consortium (RCN-UBE Introduction)
    The CBEC helps faculty at PUIs move cancer cell culture research into the classroom. The mechanism that provides faculty with the resources they need to do this are modular protocols called Cell...

    Keywords: RCN-UBE Introduction

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    Data Analysis and Cancer
    This is a flipped classroom approach, students will learn the basic content about cell-signaling, p53, and transcription factors before class. During class students will focus on data analysis...

    Keywords: Resources @ HHMI - BioInteractiveBiochemistrymolecular biologydata interpretationBiological Data Analysiscell cyclemacromoleculesGenetic diseaseCell signaling

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    Cell Collective: Learning biology with modeling and simulations
    Cell Collective is an online, research-grade modeling platform adapted to engage students in creating and simulating dynamic models of biological processes.

    Keywords: modelingsimulationSimulationsCell Collective

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    Sex-specific differences in Meiosis: Real-world applications
    In traditional classrooms, students are typically presented with facts that they are asked to memorize and recall during an exam.  The rapid explosion of available scientific facts in recent...

    Keywords: meiosisReproductionAneuploidyGameteNon-disjunctionOocyteSpermTrisomy

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    A Student-Led Hearing on the Use of HeLa Cells in Research
    In this role-playing case study, students will learn about the HeLa cell line and its origins while examining multiple perspectives surrounding the cell line and its uses. The goal of this case...

    Keywords: bioethicsscience policycell culturedebateHeLa cellsinformed consentrole playsocial justice issues

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    Diffusion Through a Cell Membrane
    This module introduces rates of diffusion in the context of understanding simple and facilitated diffusion through the cell membrane. It is intended for an introductory biology audience.

    Keywords: linear equationscalculushyperbolic equationsCellular Processesrates of change

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    Quantitative Cytological Characteristics: Photorespiration
    This module introduces quantitative cytological characteristics in the context of understanding cell behavior under stress. It is intended for an introductory biology audience.

    Keywords: plant physiologyRatioschart

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    Cell Cycle and Mitosis
    This module introduces activities that allow students to walk through the cell cycle and mitotic cell division processes. As part of the activities, students learn about and apply knowledge of...

    Keywords: introductory biologyQuantitative reasoningInterdisciplinary STEMquantitative biologyinterdisciplinaryquantitative skillscell functioncell cyclemitosisCell DivisionMitotic Indexcalculating meanstumorNIQBC2. Data and GraphsC4. mathematical modelsC3. Statistical Analysisstandard errormitotic phaseinterphase

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    Should we synthesize a human genome?
    Two articles introducing the Human Genome Project-Write and asking questions about the ethics of the project.

    Keywords: biostatisticsstatistical analysisavian malariaSummer Workshop 2018

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    Chemoreception
    This module introduces the probability of cell and molecule collisions in the context of understanding chemoreception. It is intended for an introductory biology audience.

    Keywords: linear equationshyperbolic equationsCellular ProcessesChemoreception

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    Using Yeast to Make Scientists: A Six-Week Student-Driven Research Project for the Cell Biology Laboratory
    Traditionally-trained undergraduate students often lack an understanding of science as an active process that yields the information presented in their textbooks. One result has been a call for...

    Keywords: yeastgrowth curvecell proliferationviability

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