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    Why are Cells Small? Surface Area to Volume Ratio
    This module explores surface area to volume ratios in a cube and sphere in relation to cell size.

    Keywords: introductory biologygraphingRatiosOpenStaxqbccmanipulate equationsCellular and Molecular BiologyUse elementary functionsCreate graphsInterpret graphsRates and ProportionsSolving Equations and Inequalitiesinterpret tables

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    Databases: A Study of Influenza
    This lesson introduces the student to the Influenza Research Database. Students will select Influenza genome sequences to see how they are related. Students tests hypotheses about evolutionary...

    Keywords: Bioinformatics EducationBioinformatics and Genomicsmolecular evolutionInfluenza

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    Data Analysis and Cancer
    This is a flipped classroom approach, students will learn the basic content about cell-signaling, p53, and transcription factors before class. During class students will focus on data analysis...

    Keywords: Resources @ HHMI - BioInteractiveBiochemistrymolecular biologydata interpretationBiological Data Analysiscell cyclemacromoleculesGenetic diseaseCell signaling

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    Learning with All Your Senses: Mathematical Manipulatives Enhance Student Comprehension of Biological Models
    Handout for a session presentation on kinesthetic learning at the 2019 BioQUEST & QUBES Summer Workshop

    Keywords: Models3D models3D printingmanipulativeskinesthetic learning

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    Should we synthesize a human genome?
    Two articles introducing the Human Genome Project-Write and asking questions about the ethics of the project.

    Keywords: biostatisticsstatistical analysisavian malariaSummer Workshop 2018

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    Ethics of Metabolic engineering
    This is an ethical reflection for students on an issue in metabolic engineering and the potential for "home-brew" morphine. The case study asks students to reflect on material in the linked...

    Keywords: biostatisticsstatistical analysisavian malariaSummer Workshop 2018

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    Ethics in synthetic genomics
    This is an ethical reflection for students on an issue in genome engineering and the synthesis of potentially infectious viruses. The case study asks students to reflect on material in the linked...

    Keywords: biostatisticsstatistical analysisavian malariaSummer Workshop 2018

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    Ethics of Gene Editing
    This is an ethical reflection for students on an issue in gene editing. The case study asks students to reflect on material in the two linked articles. Also included is the grading rubric.

    Keywords: biostatisticsstatistical analysisavian malariaSummer Workshop 2018

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    Does explicitly teaching leadership skills increase student persistence in STEM fields?
    Poster on leadership skills presented at the 2019 BioQUEST & QUBES Summer Workshop
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    Using Synthetic Biology to Teach Data Science
    Poster and supplemental materials on using synthetic biology to introduce students to meaningful data mining, analysis, and application to engineering novel biological constructs.
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    The p53 Gene and Cancer
    This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer.

    Keywords: Resources @ HHMI - BioInteractiveBiochemistrymolecular biologymacromoleculesGenetic disease

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    Bioinformatics: Investigating Sequence Similarity - A Plant Biology Approach
    This laboratory module is a modification of the original published on CourseSource with a focus on plant biology. In the final activity, students conduct a BLAST to compare histone protein...

    Keywords: phylogeneticsbioinformaticssequencingFASTANCBIplant biologyNIBLSEalgorithmsincubatorsPlant and Fungal EvolutionBLASTmultiple sequence alignmentsequence similarityBLOSUM scoring matrixneighbor-joining distance matrixCourseSourcephylogram

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    Sequence Similarity: An inquiry based and "under the hood" approach for incorporating molecular sequence alignment in introductory undergraduate biology courses
    This laboratory module, published on CourseSource, leads introductory biology students in the exploration of a basic set of bioinformatics concepts and tools.

    Keywords: phylogeneticsbioinformaticssequencingFASTANCBINIBLSEalgorithmsincubatorsBLASTmultiple sequence alignmentsequence similarityBLOSUM scoring matrixneighbor-joining distance matrixCourseSourcephylogramZika virus

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    HITS: A network to promote high-throughput (HT) approaches through inquiry-based case studies
    Poster on the HITS project presented at the 2018 Annual Fall Conference for the National Center for Case Study Teaching In Science.

    Keywords: case studiesbig dataHITSHigh-throughput Discovery Science & Inquiry-based Case Studies for Today’s StudentsAnnual Fall Conference for the National Center for Case Study Teaching In ScienceBuffalo case studyHigh-throughput (HT) approaches

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    Hemoglobin Evolution
    This module introduces equations describing blood viscosity and oxygen transport in the context of understanding the evolution of red blood cells. It is intended for an introductory biology audience.

    Keywords: calculushyperbolic equationsAnimal Physiologyparabolic equationsmaxima

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    Plasmodium Problem Space
    This problem space brings together diverse resources with the goal of helping biology teachers and learners engage in research investigations.

    Keywords: bioinformaticsproblem spacesNIBLSERNAseqmalariaplasmodium

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    Using Undergraduate Molecular Biology Labs to Discover Targets of miRNAs in Humans
    In this lesson, we describe an easily adaptable lab module that can be used in existing undergraduate molecular biology lab courses to conduct authentic scientific research, published in CourseSource

    Keywords: molecular biologybioinformaticsNIBLSEgene regulationmicroRNAsgene expressionCourseSourcemiRNA

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    Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes
    This lesson is a five-week series of laboratory activities designed to help students transition from applying lower order thinking skills to the central dogma to applying higher-order thinking skills.

    Keywords: bioinformaticsNIBLSEProtein StructureDNAmolecular modelinggenotypephenotypeCourseSourcecomputational modelingcentral dogmaplant leaf structure

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    Exploration of the Human Genome by Investigation of Personalized SNPs
    To increase students' interest in their own genomes, this computer-based laboratory lesson is designed to be coupled with the opportunity for the students to be genotyped by the consumer sequencing...

    Keywords: bioinformaticsNIBLSECourseSourcegenomic wide association studiesUCSC genome browsersingle nucleotide polymorphism

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    Bioinformatics: An Interactive Introduction to NCBI
    Modules showing how the NCBI database classifies and organizes information on DNA sequences, evolutionary relationships, and scientific publications. And a module working to identify a nucleotide...

    Keywords: NCBINIBLSEDNABLASTnucleotide sequencing

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