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    Predicting and classifying effects of insertion and deletion mutations on protein coding regions
    Mutations in genes can affect the encoded proteins in multiple ways, and some of these effects are counterintuitive. As for any other knowledge, students must create their own deep understanding of...

    Keywords: mutationcentral dogmatranslationframeshift

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    What is a species? Using DNA barcodes to identify species and determine insect responses to global warming
    Combining ecology, molecular tools and physiology, students investigate insect adaptation to temperatures along tropical mountains. Students integrate species concepts, DNA barcoding and thermal...

    Keywords: global warmingbeetleBiological species conceptCephaloleiacrticial thermal maximumcryptic specieselevational gradientsthermal limitstropical insectsZingiberales

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    BSL-4: Authorized Personnel Only
    National Center for Case Study Teaching in Science resource on the 2014 Ebola epidemic. This resource is also included in the NIBLSE Learning Resource Collection

    Keywords: infectious diseaseexperimental designbioinformaticsEbolaNIBLSECase It!PCRBLASTmultiple sequence alignmentPublished in National Center for Case Study Teaching in Sciencepolymerase chain reactionfebrile illnessvirusELISAenzyme linked immunosorbent assayfilovirusAfrica

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    2012-Brian_Ingalls-Mathematical_Modelling_in_Systems_Biology
    This text provides an introduction to dynamic mathematical modeling of cellular processes. The emphasis is on using computational tools to investigate models of cellular phenomena.

    Keywords: biologygene regulatory networksModelsmetabolic networkssignal transduction pathwayselectrophysiology

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    6-070-BeerBubbles-ModelingScenario
    The goal of this project is to set up and numerically solve a first-order nonlinear ordinary differential equation (ODE) system of three equations in three unknowns that models beer bubbles that...

    Keywords: molecular forensicsBEERspherebubbleNewton' Second LawIdeal Gas Lawdrag forceHadamardStokesmole

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    Discovering biodiversity in Honduras with TJ Firneno
    TJ talks to us about the different types of biodiversity, why they are important, and about his research involving the discovery of a new species of microhylid in Honduras! If you or your students...

    Keywords: geneticsmorphologyBiodiversitytaxonomyamphibians

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    Going from student to medical doctor. The pathway to medicine with Abel Edossa and Dr. Oluwatoyin Weaver
    In this "lunch with a Scientist" episode, we interviewed a medical student and medical doctor to help us understand the path to medicine. Becoming a medical doctor is a very daunting task but with...

    Keywords: medicine

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    Introductory Video and worksheets on Module 1 and 2 on "Sequence Similarity: An inquiry based and under the hood..."
    The video walks the students to complete Module 1 and 2 on Sequence Similarly and Alignment adapted from Tapprich (2019) and Hudson Alpha that teaches these modules within the context of the...

    Keywords: bioinformaticssequencingFASTANCBINIBLSEalgorithmsBLASTmultiple sequence alignmentsequence similarityBLOSUM scoring matrixCourseSource

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    Graphing bacterial growth rates: semi-log graphs v linear graphs
    In this activity, students will explore the concept of binary fission, generation time, and bacterial growth curves, with an emphasis on the log phase. Students will use semi-log graphs and linear...

    Keywords: graphingexponential growthMicrobiology Educationmicrobiologybacteriagrowth rateUndergraduate STEM educationCommunity College Educationqbccmanipulate equationsCellular and Molecular BiologyCreate graphsInterpret graphsbinary fissionsemi-log graphlinear graphgrowth curvecreating graphsExponential and Logarithmic Functions

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    HITS: A network to create inquiry-based case studies that make high-throughput approaches and discovery accessible
    HITS brings together interdisciplinary groups of HT researchers and instructors to produce authentic HT case studies that can be implemented in a variety of courses, allowing students to analyze...

    Keywords: case studieshigh-throughputHITS

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    Why are Cells Small? Surface Area to Volume Ratio
    This module explores surface area to volume ratios in a cube and sphere in relation to cell size.

    Keywords: introductory biologygraphingRatiosOpenStaxqbccmanipulate equationsCellular and Molecular BiologyUse elementary functionsCreate graphsInterpret graphsRates and ProportionsSolving Equations and Inequalitiesinterpret tables

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    Data Analysis and Cancer
    This is a flipped classroom approach, students will learn the basic content about cell-signaling, p53, and transcription factors before class. During class students will focus on data analysis...

    Keywords: Resources @ HHMI - BioInteractiveBiochemistrymolecular biologydata interpretationBiological Data Analysiscell cyclemacromoleculesGenetic diseaseCell signaling

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    Using Synthetic Biology to Teach Data Science
    Poster and supplemental materials on using synthetic biology to introduce students to meaningful data mining, analysis, and application to engineering novel biological constructs.
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    HITS: A network to promote high-throughput (HT) approaches through inquiry-based case studies
    Poster on the HITS project presented at the 2018 Annual Fall Conference for the National Center for Case Study Teaching In Science.

    Keywords: case studiesbig dataHITSHigh-throughput Discovery Science & Inquiry-based Case Studies for Today’s StudentsAnnual Fall Conference for the National Center for Case Study Teaching In ScienceBuffalo case studyHigh-throughput (HT) approaches

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    Citations
    Published Avida-Ed article

    Keywords: EvolutioncurriculumSelectionDigital Organisms

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    Central Dogma, Dictionaries, and Functions: Using Programming Concepts to Simulate Biological Processes
    Technologies like next-generation sequencing, proteomics, and high-throughput phenotyping have transformed the way we do biology. There is a continued need for scientists with computational skills...

    Keywords: computationpythonJupyter notebookFunctionscentral dogmaDictionaries

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    Engaging Students in Pharmacogenetics: Patient Case Studies Using the PharmGKB Website
    Cytochrome P450 (CYP) enzymes are important regulators of drug efficacy and toxicity. Genetic variation in CYP isoforms can impact how well patients respond to medications or experience unwanted...

    Keywords: toxicologyPharmacologydrug metabolismpharmacodynamicspharmacogenetics

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    Data Analysis Recitation Activities Support Better Understanding in SEA-PHAGES CURE
    Course-based undergraduate research experiences (CUREs) are widely known to improve student learning outcomes in the sciences. Undergraduate students have a particularly difficult time interpreting...

    Keywords: bacteriophageDNA extractionGel analysisPhage purificationTiter calculationViral replicative growth

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    Fatty Acid Induction of Lipid Droplets in Cancer Cells
    There is a growing need for the development and communication of cell culture-based laboratory activities specifically designed for undergraduate students. This multi-week laboratory activity...

    Keywords: Course based undergraduate researchCell ImagingLive Cell Staining

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    A Short Bone Biomechanics Primer: Background for a Lesson on Bone Viscoelasticity
    The skeletal system is the first of the body systems that we discuss in-depth in our Physiology & Anatomy courses (PNB 2264/2265 and PNB 2274/2275) in the Department of Physiology and...

    Keywords: structure-functionbiomechanicsAnisotropyViscoelasticity

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