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    GMC: Genes, Mutations and Cancer - Group Concept Map Development
    It has been shown that active learning strategies used in the classroom can increase student learning and retention of information. We generated an active learning exercise that can be used in the...

    Keywords: mutationcancerCell Division

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    Cystic Fibrosis Mechanism and Treatment
    This animation shows how mutations in an ion channel protein lead to the genetic disease cystic fibrosis. The animation also discusses how research on this protein has been used to develop...

    Keywords: Resources @ HHMI - BioInteractiveBiochemistrymacromoleculesGenetic diseaseCell Structure & Function

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    Using Raw Sequence Data to Analyze Tumor Suppressor Mutations
    Learning to identify DNA sequence variants from raw sequencing data (electropherograms) is a basic molecular biology skill with applications to basic research and clinical practice. Yet learning to...

    Keywords: bioinformaticsmutationDNAgenomic visualizationparts of a geneclinical consequencesraw data

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    Harnessing the Power of the Immune System: Influenza Vaccines
    Because most people have been infected by and/or immunized against influenza, students should know how the immune system responds to the infection and how vaccines protect against disease. Vaccines...

    Keywords: VaccinesInfluenzaImmunizationVaccine efficacy

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    Sequence Similarity: An inquiry based and "under the hood" approach for incorporating molecular sequence alignment in introductory undergraduate biology courses
    Introductory bioinformatics exercises often walk students through the use of computational tools, but often provide little understanding of what a computational tool does "under the...

    Keywords: BLASTmultiple sequence alignmentsequence similarityphylogramZika virusAlgorithmScoring Matrix

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    Fostering Student to Student Collaboration Across Institutions in a Protein Centric CURE
    Collaboration is an essential component of research because it allows scientists to share expertise and tackle difficult scientific questions. While many undergraduate science courses include...

    Keywords: communicationBiochemistrycollaborationCUREhypothesisStudent to StudentInter institutionalProtein CentricAssignments

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    The Leaky Neuron: Understanding synaptic integration using an analogy involving leaky cups
    Students have difficulty understanding synaptic integration in neural circuits, and how spatial and temporal summation combine in a target neuron to reach threshold.  This Lesson uses small...

    Keywords: neuron physiologyspatial summationsynaptic integrationtemporal summationthreshold

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    The Happy Blue Baby Hemoglobin
    This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved.

    Keywords: mutationHemoglobinmolecular visualization and analysisPDBMolecular Case Study

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    Bacteria to Brains in Backyard Coyotes: An Interdisciplinary Pedagogical Case Study
    Our interdisciplinary pedagogical case study explores the differences between rural and urban coyotes at the levels of organismal and community ecology. The focus is on how coyotes’ gut microbiomes...

    Keywords: Vision and Changeecologyintroductory biologyImmunologymicrobiologydietanimal behaviormicrobiomecore conceptscoyotesBraingut-brain axisImmunoReachcytokinedysbiosis

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    How to Find a Gene: Retrieving Information From Gene Databases
    A strong understanding of distinct gene components and the ability to retrieve relevant information from gene databases are necessary to answer a diverse set of biological questions. However, often...

    Keywords: NCBItranscriptiontranslationGene StructureGene databasesEnsembl

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    Venom: To Kill or Cure?
    In this case study, students will explore concepts of evolution, protein structure and function, taxonomy, and methods of scientific inquiry in a real-world way.

    Keywords: EvolutionphylogeneticsidigbioAP Biologytaxonomynatural history collections3D modelsoVertVenomsnakesherps

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    Molecular Basis of Sickle Cell Disease
    This multi part case on hemoglobin structure as it relates to oxygen binding and sickle cell disease focuses on utilizing bioinformatics and molecular visualization tools to learn about the sickle...

    Keywords: Hemoglobinmolecular visualization and analysisintroductory bioinformaticssickle cell diseasePDBMolecular Case Studyoxygen bindingmyoglobinmolecular literacy3D protein structuresstructural representations

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    Students Authoring Molecular Case Studies
    Poster on using case studies to help students develop their skills in reading primary literature and identifying authentic scientific problems by authoring their own case studies. Presented at the...

    Keywords: case studiesProtein StructureProtein Data BankMolecular Case Study2021 BIOME

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    It's a Substrate... It's a Protein...No - It's an Enzyme! Teaching Using 3D Serine Protease Physical Modeling Activities to Confront Misconceptions.
    Reported misconceptions of enzyme-substrate interactions highlight the necessity for better, targeted instructional tools and assessments. A series of active learning activities with corresponding...

    Keywords: Protein StructureEnzymes-Substrate InteractionsNoncovalent InteractionsGeometric ComplementaryElectronicsStereochemistrySerine Proteases

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    Cell Signaling Pathways - a Case Study Approach
    Signaling and gene expression are fundamental to cell biology and developmental biology. Although these topics are highly interrelated, they typically appear in separate units in a course. We use a...

    Keywords: signal transductiongene expressionCell communicationgenetic disordersregulation of enzyme activity

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    Discovering Prokaryotic Gene Regulation with Simulations of the trp Operon
    The trp operon exemplifies important biological concepts, including the central dogma of molecular biology, feedback inhibition, and gene regulation. For this reason, regulation of the trp operon...

    Keywords: prokaryotesgene regulationattenuationfeedback inhibitionrepressible operontrp operon

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    A Short Laboratory Module to Help Infuse Metacognition during an Introductory Course-based Research Experience
    A core competency identified in Vision and Change for undergraduate biology students is the Ability to Apply the Process of Science. Here, we describe a three-week laboratory module for students in...

    Keywords: metacognitiongene expressionScientific ProcessExperimenal DesignHypothesis Generationmodel organisms

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    Lights, Camera, Acting Transport! Using role-play to teach membrane transport
    Lights, Camera, Acting Transport! is an active and unique role-play exercise designed to teach introductory biology students basic concepts of passive and active membrane transport. The activity...

    Keywords: ATPcarrierschannelsco-transportelectrogenic pumpfacilitated diffusionmembrane transportpassive transportprimary active transportsimple diffusion

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    Necessary and Sufficient? Solving the Mystery of the Mitochondrial Pyruvate Transporter
    While there are several available lessons for teaching introductory biology students about diffusion, facilitated diffusion, and active transport, fewer materials exist to support upper-division...

    Keywords: DiffusionActive transportfacilitated diffusionNecessary and sufficientTransport proteins

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    Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes
    This lesson is a five-week series of laboratory activities designed to help students transition from applying lower order thinking skills to the central dogma to applying higher-order thinking skills.

    Keywords: bioinformaticsNIBLSEProtein StructureDNAmolecular modelinggenotypephenotypeCourseSourcecomputational modelingcentral dogmaplant leaf structure

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