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    Regulation of Gene Expression and Adipogenesis by PPAR-γ
    Students learn about transcriptional regulation of PPAR-γ, an important controller of adipose tissue stores and energy metabolism through a drawing/coloring activity of the different components...

    Keywords: gene expressionsmall group worktranscriptional regulationadipose tissuefat metabolismrepressor

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    3D breast cancer tissue reconstruction image files
    Database of image files for AIMS Resource: 3D breast cancer tissue reconstruction

    Keywords: Resources @ AIMS

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    1968-Wagner-Aghajanian-Bing-Correlation of performance test scores with tissue concentration of lysergic acid diethylamide
    This paper offers a two compartment model of lysergic acid diethylamide (LSD) in volunteer students and through parameter estimation models the amount of LSD in the tissue after its initial...

    Keywords: LSDcorrelation coefficientcompartment modellysergic acid diethylamideperformancetest scoretissue concentration

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    Using a Primary Cell Culture Model to Study the Neural Extracellular Matrix
    The extracellular matrix (ECM) provides structural support to cells, but also has key roles in mediating cell adhesion, cell signaling, and differentiation. While this topic is discussed in the...

    Keywords: Neural extracellular matrixPerineuronal netPrimary neuronal culture

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    GEA Introductory lesson on RNA-Seq
    This RNA-Seq lesson uses the CyVerse VICE Platform and Jupyter notebooks to examine the expression of the leptin gene in samples from a mouse experimental design evaluating diet (high-fat vs....

    Keywords: data sciencebioinformaticsGenome BrowserRNAseqhigh throughput sequencingmRNAAlignmentNCBI Sequence Read Archive

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    2006-Han-EtAl-Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology
    Physiologically-based pharmacokinetic (PBPK) models have been used to describe the distribution and elimination characteristics of intravenous ethanol administration.

    Keywords: liverwortsintraveneouspharmacokineticsethanolethanol infustionpharmacodynamictissue model

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    5-020-ParacetamolAbsorption-ModelingScenario
    We offer drug absorption data on paracetamol, an analgesic pain reliever, for two different sets of patients, vegetarian and non-vegetarian. Students build a two compartment model for plasma and...

    Keywords: paracetamolanalgesicvegetariannon-vegetarian

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    2004-Jones-Song-Thomas-Controlling wound healing through debridement
    In this article, a system of differential equations that models slough/wound interaction is developed.

    Keywords: bacteriawound healinghealingderidingisocline

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    5-012-LipoproteinModeling-ModelingScenario
    Data from a study on the amounts of low-density-lipoprotein (LDL), form of cholesterol, in blood plasma is presented. Students build, validate, and use a compartment model of the kinetic...

    Keywords: wildlifelow-density-lipoproteintracercompartment modelcholesterolblood plasmabody tissue

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    3D breast cancer tissue reconstruction
    This module allows students to follow a researcher as she discovers new features of breast cancer tissue architecture, using 3D reconstructions of histological specimens.

    Keywords: graphingdata visualizationbreast cancerDCIShistogramscentroidsums of squares

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    1957-Axelrod_ Brady_Witkop_Evarts-The Distribution and Metabolism of Lysergic Acid Diethylamide
    The development of a specific and sensitive method for the estimation of LSD in biological materials has enabled us to study the tissue distribution, excretion, rate of biotransformation, and...

    Keywords: mathematical modeldataLSDMetabolismbloodstreamlysergic acid diethylamidedistribution

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    Nastic Movements in Plants
    This module introduces an osmotic model in the context of understanding plants' capability of rapidly adapting to changes in their environment. It is intended for an introductory biology audience.

    Keywords: plant physiologyhyperbolic equationsOpenStaxinterpreting modelsnastic movements

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    Cell Division and Cancer Risk Data Point
    Cancer is typically attributed to hereditary and environmental factors, but these only explain a fraction of overall cancer risk. This activity explores a third factor.

    Keywords: Resources @ HHMI - BioInteractivecancerScientific ProcessStatistics and MathScientific Methodologybiology of cellscell growth and divisionHigh School

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    2000-Erdman-Morelock-A Study of Kinetics The Estimation and Simulation of Systems of First-Order Differential Equations
    This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.

    Keywords: kineticsSAScompartmentpharmacokinetics

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    1996-D_Erdman-MM_Morelock-A Study of Kinetics
    This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.

    Keywords: simulationkineticsparameter estimationEnzymesubstratesavingscompartmentstomachbloodginseng

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    9-001-SkinBurnModelNumericalMethods-TechniqueNarrative
    The heat equation is an important partial differential equation (PDE) which describes the distribution of heat in a given region over time. Numerical methods play an important role in solving these.

    Keywords: Maternal-Fetal interfaceheat equationConservation of Energytheat fluxEuler's forward methodcentral differenceskin burnhyperthermiathermal conductivitylayers

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    Attract or Defend? Secondary Compounds among tissues in two species of Lupine (Fabaceae)
    This plant-biology data analysis module compares concentrations of defensive alkaloid compounds among tissue types in two species of the flowering-plant Lupine (Fabaceae). Students practice with...
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    A Walk Through the Woods
    Data driven curriculum module from Dryad Digital Repository

    Keywords: ecologygraphingResources @ Dryadhypothesis testingdata visualizationbotanyclimate changeadaptationforestryDryadLabhypothesis formulationenvironmental pressureswood structure and function

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    Agents of change: Determining effects of pollution on marine environments through data interpretation
    In this lesson, students discuss the effects of disturbance in marine environments with a focus on pollution. They also evaluate the anthropogenic causes and consequences of pollution on a variety...

    Keywords: fishgraph interpretationfmnmarine ecosystemsmarine ecologymicroplastic pollutionEcological Disturbanceintermediate disturbance hypothesisstudent STEM identitypollutionBioGraphIrepresentation in STEMoil spill

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    1-132-DigoxinElimination-ModelingScenario
    We model the concentration of digoxin eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study...

    Keywords: nullclinespharmacokineticsdigoxindrug eliminationtwo compartment

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