You are here: Home / Resources / Browse Resources

Open. Adaptable. Free.

Resources created by our members and partners.

The QUBES platform hosts hundreds of teaching materials, reference materials, and cloud-based software free to use and adapt using open Creative Commons licenses.

Text Search:
Applied Filters
    2016-Wilkie-EtAl-Using ODEs to Explore Cancer-Immune Dynamics and Tumor Dormancy
    Here we present a general method using ordinary differential equations (ODEs) to model and analyze cancer-immune interactions, and in particular, immune-induced tumor dormancy.

    Keywords: cancertumor-inhibiting cytotoxic actiontumor-promoting inflammationimmune-induced tumor dormancytumor growth dynamics

    171

    views

    56

    downloads

    0

    comments

    0

    adaptations

    6-017-OncolyticViruses-ModelingScenario
    Students explore oncolytic virotherapy using systems of differential equations and numerical simulations.

    Keywords: cancercancer-immune dynamicsimmune suppressor drugoncolytic virusvirotherapy

    461

    views

    129

    downloads

    0

    comments

    0

    adaptations

    2017-Fred_Adler-Mathematically Modeling Asthma
    Our Asthma models have examined how a viral infection can tip the immune system into a different state, with the potential to predispose an individual to future asthma

    Keywords: infectionasthmaimmune responserhinovirus

    146

    views

    102

    downloads

    0

    comments

    0

    adaptations

    2015-Heiko_Enderling-Integrating experimental data to calibrate quantitative cancer models
    For quantitative cancer models to be meaningful and interpretable the number of unknown parameters must be kept minimal. We focus on a tumor hierarchy of cancer stem and progenitor non-stem cancer...

    Keywords: cancertumorfittingagent-based

    154

    views

    86

    downloads

    0

    comments

    0

    adaptations

    2017-Bonin-EtAl-Mathematical modeling based on ordinary differential equations - promising approach to vaccinology
    As a proof of concept, we developed a model of the immune response to vaccination against the yellow fever. Our simulations have shown consistent results when compared with experimental data...

    Keywords: immune systemyellow fevercomputational immunologycomputational vaccinology

    147

    views

    57

    downloads

    0

    comments

    0

    adaptations

    2016-Bonin-EtAl-Mathematical modeling based on ordinary differential equations-vaccinology
    We developed a model of the immune response to vaccination against the yellow fever. Our simulations have shown consistent results when compared with experimental data available in the literature.

    Keywords: Immunologyimmune systemAntigenvaccinologyyellow fever

    161

    views

    82

    downloads

    0

    comments

    0

    adaptations

    2006-Loyd-Wodarz-Drug Resistance in Acute Viral Infections-Rhinovirus as a Case Study
    We develop an epidemiological model that can be used to address the spread of resistance at the population level, and a virus dynamics model that can be used to study the dynamics of virus over the...

    Keywords: stabilityresistancevirusdrugepidemic competitionimmune responserhinovirus

    147

    views

    51

    downloads

    0

    comments

    0

    adaptations

    Migration Assay Protocol
    Migration is a key property of live cells and critical for normal development, immune response, and disease processes such as cancer metastasis and inflammation.

    Keywords: migration assay

    67

    views

    21

    downloads

    0

    comments

    0

    adaptations

    CYTOSKELETON - Microtubule Dynamics in the Cell Cycle
    This module contains exercises designed to help upper-level cell biology students understand the dynamics of microtubule polymerization and depolymerization within the cell cycle and how cancer...

    Keywords: cell biologyQuantitative reasoningInterdisciplinary STEMInterpreting GraphsCytoskeletonScientific reasoningdimensional analysisNIQBC2. Data and GraphsC6. Quantitative LanguageC1. Numeracy

    526

    views

    514

    downloads

    0

    comments

    0

    adaptations

    1-150-CancerTherapy-ModelingScenario
    This activity builds upon elementary models on population growth. In particular, we compare two different treatment models of cancer therapy where in one, surgery happens before therapy and in the...

    Keywords: population dynamicsphage therapyexponential growthcancerwater treatmentdecaysurgery

    446

    views

    357

    downloads

    0

    comments

    0

    adaptations

    Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson
    There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has...

    Keywords: bioinformaticscancertranscriptomicshigh-throughputData wranglingSingle cell RNA sequencingq

    6611

    views

    1645

    downloads

    0

    comments

    0

    adaptations

    2016-Lewnard-Townsend-Climatic and evolutionary drivers of phase shifts in the plague epidemics of colonial India
    Our analysis shows that historical datasets can yield powerful insights into the transmission dynamics of reemerging disease agents with which we have limited contemporary experience to guide...

    Keywords: infectious diseasepVector-Borne Diseaselagueplague

    140

    views

    55

    downloads

    0

    comments

    0

    adaptations

    Cells of the Immune System
    This tutorial provides an overview of the immune system, concentrating on the roles played by B and T lymphocytes, and on the antigen-presentation system.
    1388

    views

    209

    downloads

    0

    comments

    0

    adaptations

    3D breast cancer tissue reconstruction image files
    Database of image files for AIMS Resource: 3D breast cancer tissue reconstruction

    Keywords: Resources @ AIMS

    1090

    views

    144

    downloads

    0

    comments

    0

    adaptations

    Cancer Discovery Activities
    These two hands-on activities are based on a Howard Hughes Medical Institute 2013 Holiday Lectures on Science video (http://www.hhmi.org/biointeractive/cancer-genetic-disease-video-highlights)...

    Keywords: geneticsResources @ HHMI - BioInteractiveorganismal biologyneurosciencegenomicscancergenetic basis of diseasebiology of cellsHigh School

    1956

    views

    341

    downloads

    0

    comments

    2

    adaptations

    Online Information Literacy: Applying the CRAAP Test to Vaccine (Mis)information
    Teaching scientific literacy skills can help combat the propagation of misinformation online. This lesson is intended to give students practice identifying reliable scientific information on the...

    Keywords: Vaccinesimmunityreliability

    2436

    views

    172

    downloads

    0

    comments

    0

    adaptations

    2011-Radouane_Yafia-A Study of Differential Equations Modeling Malignant Tumor Cells in Competition with Immune System
    In this paper, we present a competition model of malignant tumor growth that includes the immune system response. The model considers two populations: immune system (effector cells) and population...

    Keywords: Immunologytumorhopf bifrucation

    238

    views

    57

    downloads

    0

    comments

    0

    adaptations

    Understanding the Importance of Microtubules in Normal Cell Division: Chemotherapy Connection
    In introductory courses, students learn about microtubules as important structures but may not engage in a hands-on experience to localize microtubules themselves or to learn about their connection...

    Keywords: cancerCell DivisionimmunofluorescenceMicrotubulesAntibodies

    1191

    views

    137

    downloads

    0

    comments

    0

    adaptations

    Calculating Lifetime Cancer Risk Resulting from DNA Replication
    An expanded case study adapted from an HHMI Data Point on Cell Division and Cancer Risk using Figure 1 from Tomasetti, C. and Vogelstein, B. (2015).

    Keywords: cancerScientific ProcessStatistics and MathScientific Methodologybiology of cellscell growth and divisionHigh School

    1526

    views

    1119

    downloads

    0

    comments

    0

    adaptations

    Cell Division and Cancer Risk Data Point
    Cancer is typically attributed to hereditary and environmental factors, but these only explain a fraction of overall cancer risk. This activity explores a third factor.

    Keywords: Resources @ HHMI - BioInteractivecancerScientific ProcessStatistics and MathScientific Methodologybiology of cellscell growth and divisionHigh School

    2615

    views

    364

    downloads

    0

    comments

    1

    adaptations

    Close

    Home

    Search