An expanded case study adapted from an HHMI Data Point on Cell Division and Cancer Risk using Figure 1 from Tomasetti, C. and Vogelstein, B. (2015).
Adapted from: Cell Division and Cancer Risk Data Point v 1.0
Student interest in cancer as a topic of study and discussion is high, as most students can closely identify with the impact of cancer on an individual and their loved ones. DNA replication and repair is a topic essential to understanding reproduction and is foundational to students' understanding of gene expression. This module seeks to address two distinct learning goals, one that is content-based and one that is develops quantitative competency in freshman biology students.
Learning Goals for "Calculating Lifetime Cancer Risk Resulting from DNA Replication"
- To give students context for the importance of high fidelity DNA repair by capitalizing on their inherent interest in cancer and curiosity as to what causes cancer.
- To develop students' science process skills by teaching experimental design as well as developing skills in scientific notation, relationships between two variables in a scatter plot, and correlation between variables.
- CG_Cancer_Orr_KH_RB_RO5_MC_RO.pptx(PPTX | 1 MB)
- DNA_Cancer_Instructor2.docx(DOCX | 145 KB)
- DNA_Cancer_studenthandout3a2.docx(DOCX | 435 KB)
- DNA_Cancer_Studenthandout3b2.docx(DOCX | 227 KB)
- Cell Division and Cancer Risk | HHMI BioInteractive
- Variation in cancer risk among tissues can be explained by the number of stem cell divisions | Science
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Cite this work
Researchers should cite this work as follows:
- Orr, R., Buskirk, R., Harvey, K. (2018). Calculating Lifetime Cancer Risk Resulting from DNA Replication. HHMI BioInteractive, QUBES Educational Resources. doi:10.25334/Q47H6Z