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    A discussion of C-Path, regulation science, and recommended drug treatments with Nicholas King
    Nicholas King acts as the Scientific Program Manager for the Critical Path (C-Path) Institute’s Biomarker Program. He discusses the journey he has been on to arrive at his position, what the...

    Keywords: healthCollaborative researchdrug discovery

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    2006-Graves-Peckham-Pastor-2D differential equations model for mutualism
    We develop from basic principles a two-species differential equations model which exhibits mutualistic population interactions.

    Keywords: population dynamicsLotka-Volterragrowth ratemutualismLichen

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    Harnessing the Power of the Immune System: Influenza Vaccines
    Because most people have been infected by and/or immunized against influenza, students should know how the immune system responds to the infection and how vaccines protect against disease. Vaccines...

    Keywords: VaccinesInfluenzaImmunizationVaccine efficacy

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    The (STEM)2 Network - Sustainable, Transformative Engagement across a Multi-Institution and Multidisciplinary STEM Network (RCN-UBE Introduction)
    Enhance undergraduate STEM education by promoting new and strengthening existing collaborations among biology, chemistry, and math faculty at 2- and 4-year institutions; and support faculty in...

    Keywords: RCN-UBE Introduction

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    Promoting Climate Change Literacy for Non-majors: Implementation of an atmospheric carbon dioxide modeling activity as an inquiry-based classroom activity
    Students who are directly involved in scientific activities develop a deeper understanding and appreciation of both scientific knowledge and the scientific process. This understanding is critically...

    Keywords: modelingExcelquantitativeclimate changeEnvironmental Biologyatmospheric carbon dioxide

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    To Vaccinate or Not to Vaccinate
    To vaccinate or not to vaccinate, that is the question. Much of the recent trend in society against vaccination is that the general population does not understand 1) how vaccines work and 2) how...

    Keywords: pathogenELISAimmunityantibodyAntigen

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    Wolf Sheep Predation Simulation Exercise
    This resource is an exercise to introduce students to agent-based modeling of biological systems through working with a simple existing model.

    Keywords: simulationecologyIntroductoryNetLogoagent-based modelingagent-based modelLabbioinformaticspredator-preyUndergraduateNIBLSEInstructional SettingAudience LevelActivity LengthLess than 1 hoursimulation cycleC1. Role of bioinformaticsC6. ModelsReviewed at NIBLSEagent based modleing

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    1975-Rodda-Sampson-Smith-The One-Compartment Open Model Parameter Estimation
    A new estimation procedure is proposed for estimating the parameters of the simplest pharmacokinetic model, the one-compartment open model.

    Keywords: compartment modelpharmacokineticsnonlinear estimationone compartment model

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    "Reading groups" in an undergraduate biology course: A peer-based model to help students develop skills to evaluate primary literature
    Undergraduates who learn to evaluate primary literature demonstrate an enhanced ability to understand the process of science, weigh scientific evidence, and think critically (e.g. 6,8). Studies...

    Keywords: primary literaturecritical thinkingSelf-EfficacyDiscussionPeer-based Learning

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    2018-Hu-Huang-Dynamic Regulation Responding to an External Stimulus
    This study examines the dynamic regulation process responding to an external stimulus. This study introduces the driven damped oscillator model which has an additional parameter to identify...

    Keywords: dynamical systemsregulationsteady statesales modelexternal stimulus

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    The Science Behind the ACTN3 Polymorphism
    A common polymorphism in the alpha-actinin-3 (ACTN3) gene results in the lack of ACTN3 protein expression in fast twitch muscle fibers in ~16% of the human population (1). This genetic change has...

    Keywords: protein structure and functionhuman genetic variationskeletal muscle physiology

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    Necessary and Sufficient? Solving the Mystery of the Mitochondrial Pyruvate Transporter
    While there are several available lessons for teaching introductory biology students about diffusion, facilitated diffusion, and active transport, fewer materials exist to support upper-division...

    Keywords: DiffusionActive transportfacilitated diffusionNecessary and sufficientTransport proteins

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    Using QIIME to Interpret Environmental Microbial Communities in an Upper Level Metagenomics Course
    Metagenomics is rapidly evolving due to advances in sequencing technologies and bioinformatics, but without proper training to interpret these datasets, student understanding remains limited. Aimed...

    Keywords: microbiome

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    1994-T_Gruszka-A_Balloon_Experiment_in_the_Classroom
    The experiment consists of dropping a balloon from two different heights and recording the time it takes to hit the floor. The following experiment involves a balloon, a stopwatch, and a...

    Keywords: differential equationsresistancegravityfree fallaccelerationballoon

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    2010-Kijek-Kijek-Modelling of Innovation Diffusion
    This paper offers a first order differential equation model for innovation diffusion, solves it, and offers qualitative analysis as well as approaches to estimating parameters with some data on...

    Keywords: Bass modelinnovation diffusionLogistic modeldynamic model

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    Teaching Advanced Concepts in Regulation of the Lac Operon With Modeling and Simulation
    Success in biochemistry and other life science courses requires that students understand important biological concepts. One of these concepts is how gene regulation ensures that homeostasis is...

    Keywords: gene regulationinducible operonProkaryotic cellPhosphoenolpyruvate transferase system (PTS)

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    Building a Model of Tumorigenesis: A small group activity for a cancer biology/cell biology course
    The multistep nature of tumorigenesis is a foundational concept in the context of Cancer Biology. Many students do not appreciate the complex nature of cancer development nor do they understand how...

    Keywords: pathwayscancerMolecular AlterationsRetrospective dataTumorigenesis

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    2014-Vance-Eads-Sensitivity Analysis of a Three-Species Nonlinear Response Omnivory Model with Predator Stage Structure
    We investigate a three-species nonlinear response omnivory model incorporating stage structure in the top predator. The model consists of four coupled ordinary differential equations involving...

    Keywords: stage structuresensitivity analysismortalityomnivoreomnivory modelsearch rates

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    2010-Del-Ciello-EtAl-Modeling Disease
    We model the transmission of a disease through a population. Such modeling is very important to the study of epidemiology and the practice of medicine.

    Keywords: diseasespreadcarriessymptomaticasymptomatic

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    2003-Yildirim-Mackey-Feedback Regulation in the Lactose Operon
    A mathematical model for the regulation of induction in the lac operon in Escherichia coli is presented.

    Keywords: mRNAlactoselactose operonfeedback regulation

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