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    A discussion of C-Path, regulation science, and recommended drug treatments with Nicholas King
    Nicholas King acts as the Scientific Program Manager for the Critical Path (C-Path) Institute’s Biomarker Program. He discusses the journey he has been on to arrive at his position, what the...

    Keywords: healthCollaborative researchdrug discovery

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    2014-C_W_Groetsch-S_A_ Yost-Vertical Projection_in_a_Resisting_Medium_Revelations_on_Observations_of_Mersenne
    This article, inspired by a 17th-century woodcut, validates empirical observations of Marin Mersenne (1588–1648) on timing of vertically-launched projectiles for a general mathematical model of...

    Keywords: resistanceprojectile motionprojectilefluidMersenne

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    3-065-UpDown-ModelingScenario
    We model the height of a launched object which is subject to resistance proportional to velocity during its flight. We ask questions about the motion as well, e.g., highest point or apex and...

    Keywords: terminal velocityNewton's Second Law of Motionvelocitymotionapex

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    3-013-WhiffleBallFall-ModelingScenario
    We are given data on the time and position of a whiffle ball as it falls to the ground. We attempt to model the falling ball and we confront the different resistance terms and models.

    Keywords: Akaike Information CriterionresistancegravityFree Body Diagramforcefalling objectWhiffle ball

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    3-075-RLCCircuits-ModelingScenario
    We introduce the basics of RLC circuits, defining the terms of inductance, resistance, and capacitance in a circuit in which an induced voltage created a current running through these devices.

    Keywords: resistancecircuitvoltageinductancecapacitancecurrentKirchhoff's Law

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    Engaging Students in Pharmacogenetics: Patient Case Studies Using the PharmGKB Website
    Cytochrome P450 (CYP) enzymes are important regulators of drug efficacy and toxicity. Genetic variation in CYP isoforms can impact how well patients respond to medications or experience unwanted...

    Keywords: toxicologyPharmacologydrug metabolismpharmacodynamicspharmacogenetics

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    5-011-ModelingIbuprofren-ModelingScenario
    We consider modeling of data from a clinical experiment administered as oral doses of 400 mg ibuprofen, an analgesic pain reliever. Concentrations of ibuprofen in the serum/plasma of the subjects...

    Keywords: dataAICAkaike Information Criterionabsorptionsum of square errorscompartment modelibuprofendelay

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    Opioid crisis: exploring the neurophysiology of opioid receptor signaling
    Using this dataset, we explore how opioids affect the electrical activity of neurons when exposed to different opioid receptor agonists and antagonists.

    Keywords: opioid epidemic

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    Nicholas' Story
    This 3 part case on sickle cell disease focuses on visualizing and understanding the molecular basis of its cause, symptoms, complications, management, treatment, and possible cures.

    Keywords: Hemoglobinmolecular visualization and analysissickle cell diseasePDBMolecular Case Study

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    Nicholas' Story
    This 3 part case on sickle cell disease focuses on visualizing and understanding the molecular basis of its cause, symptoms, complications, management, treatment, and possible cures.

    Keywords: Hemoglobinmolecular visualization and analysissickle cell diseasePDBMolecular Case Study

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    Application of a Bacterial Experimental Evolution System to Visualize and Teach Evolution in Action: A Course-Based Undergraduate Research Experience
    Concepts of evolution are typically taught through examples of extremely long timescales, which do not always resonate broadly. Here, we describe a course-based undergraduate research experience...

    Keywords: EvolutionmutationcompetitionNatural Selectionregulationstructure and functionreproductive fitnessgenotype to phenotypehomologs

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    2016-Lewnard-Townsend-Climatic and evolutionary drivers of phase shifts in the plague epidemics of colonial India
    Our analysis shows that historical datasets can yield powerful insights into the transmission dynamics of reemerging disease agents with which we have limited contemporary experience to guide...

    Keywords: infectious diseasepVector-Borne Diseaselagueplague

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    1-128-RocketFlight-ModelingScenario
    We offer an opportunity to build a mathematical model using Newton's Second Law of Motion and a Free Body Diagram to analyze the forces acting on the rocket of changing mass in its upward flight...

    Keywords: resistanceFlightRocketrymassNewton's Second Law of MotionthrustFree Body Diagramapexrocket

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    5-040-TunedMassDampers-PartII-ModelingScenario
    Studentsbuild mathematical models to mitigate dangerous swaying in structures using structural improvements called Tuned Mass Dampers (TMD). We model the motion of the original structure as a...

    Keywords: structureresistancespring-mass-dashpotearthquakevibrationcontroldampingtuned mass damperstiffnessreduction of vibration

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    4-060-CircuitTuner-ModelingScenario
    We present essential definitions and laws for the study of simple RLC electrical circuits and build a differential equation model using these notions. We describe how such a circuit can be used to...

    Keywords: resistanceciircuittuned mass tunerfrequencyKirchhoffvoltagegainfrequency responseamplitudes Voltage LawinductancecapacitorI am currently working in redesining an existing microbiology course. I would like to be part of ed

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    3-070-FallingInWater-ModelingScenario
    We model a small canister with ballast to keep it vertical as it falls through water in a graduated cylinder filled with water. We suggest several models in terms of resistance due to the media and...

    Keywords: datawaterresistancefallingbuoyancymass

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    Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson
    There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has...

    Keywords: bioinformaticscancertranscriptomicshigh-throughputData wranglingSingle cell RNA sequencingq

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    Tiny Earth: Studentsourcing antibiotic discovery
    Poster on Tiny Earth presented at the 2020 BIOME Institute: Cultivating Scientific Curiosity

    Keywords: antibiotic-resistancesoil microbiologyTiny Earth

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    Mendelian Genetics, Probability, Pedigree, and Chi-Squared Statistics
    A lesson that requires students to work through a series of questions pertaining to the genetics of sickle cell disease and its relationship to malaria.

    Keywords: geneticsResources @ HHMI - BioInteractiveScientific ProcessStatistics and Mathmendelian inheritance

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    1980-Peastrel-Lynch-Armenti-Terminal velocity of a shuttlecock in vertical fall
    We have performed a straightforward vertical fall experiment for a case where the effects of air resistance are important and directly measurable.

    Keywords: fallingterminal velocityshuttlecockvertical fall

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