QUBES will have scheduled maintenance work beginning on Wednesday, June 26, 2024, 4pm ET/1pm PT. The platform will operate normally for most of the day, except for an extended outage period lasting no more than 4 hours. All running tool sessions will expire during the maintenance window. Please plan accordingly and we do apologize for any inconvenience. close

You are here: Home / Resources / Browse Resources

Open. Adaptable. Free.

Resources created by our members and partners.

The QUBES platform hosts hundreds of teaching materials, reference materials, and cloud-based software free to use and adapt using open Creative Commons licenses.

Text Search:
Applied Filters
    An evolution curriculum designed around understanding the rise and spread of drug-resistant pathogens
    Poster on teaching concepts in evolution and data science skills in an upper level Biology elective at Spelman College presented at the 2018 QUBES/BioQUEST Summer Workshop

    Keywords: EvolutionRdata sciencedrug resistanceSummer Workshop 2018

    1300

    views

    148

    downloads

    0

    comments

    0

    adaptations

    2006-Loyd-Wodarz-Drug Resistance in Acute Viral Infections-Rhinovirus as a Case Study
    We develop an epidemiological model that can be used to address the spread of resistance at the population level, and a virus dynamics model that can be used to study the dynamics of virus over the...

    Keywords: stabilityresistancevirusdrugepidemic competitionimmune responserhinovirus

    101

    views

    40

    downloads

    0

    comments

    0

    adaptations

    2008-Huangi-Lu-Modeling long-term longitudinal HIV dynamics with applications to an AIDS clinical study 
    To better understand the factors responsible for the virological failure, this paper develops the mechanism-based nonlinear differential equation models for characterizing long-term viral dynamics...

    Keywords: longitudinal dataAIDSantiretroviral drug therapyBayesian nonlinear mixed-effectstime-varying drug efficacyHIV dynamics

    98

    views

    28

    downloads

    0

    comments

    0

    adaptations

    2004-Ledzewicz-Schattler-Application of Control Theory in Modelling Cancer Chemotherapy
    In this paper we discuss how to incorporate more realistic medical aspects of chemotherapy which hitherto have been neglected in the models.

    Keywords: optimal controldrug resistancepharmacokineticspharmacodynamicschemotherapy

    101

    views

    37

    downloads

    0

    comments

    0

    adaptations

    Drug screening and cancer resistance: EGFR Activity
    This activity explores a specific gene (egfr) and its role in cancer. EGFR was introduced with the Gene Card Activities, researched throughout the semester, and then authentic image data of...

    Keywords: Resources @ HHMI - BioInteractivegenomicscancergenetic basis of diseasebiology of cells

    1245

    views

    1330

    downloads

    0

    comments

    0

    adaptations

    Mock Drug Activity Enhances Student Learning About the Challenges of HIV/AIDS Therapy
    While traditional didactic coursework is important for learning about the scientific aspects of HIV/AIDS, it is difficult to convey social aspects of the epidemic. Due to effective drug therapies,...

    Keywords: drug resistanceRetrovirusViral replication

    1072

    views

    134

    downloads

    0

    comments

    0

    adaptations

    Using genomic data and machine learning to predict antibiotic resistance: a tutorial paper
    Antibiotic resistance is a global public health concern. Bacteria have evolved resistance to most antibiotics, which means that for any given bacterial infection, the bacteria may be resistant to...

    Keywords: Tutorialmachine learningantibiotic-resistanceArtificial Intelligence

    234

    views

    84

    downloads

    0

    comments

    0

    adaptations

    3-027-BobbingDropping-ModelingScenario
    We present two exercises in which we ask students to model (1) falling object experiencing terminal velocity and (2) bobbing block of wood in liquid. We model the motion using Newton's Second Law...

    Keywords: drug resistancedirectedbuoyancyfree fallstatic equilibriumdisplacement

    196

    views

    106

    downloads

    0

    comments

    0

    adaptations

    Antibiotic Resistance Genes Detection in Environmental Samples
    Our aim is to provide an authentic research experience for undergraduate students in a variety of biology courses through collaboration between a four-year university and a community college. This...

    Keywords: geneticsenvironmentmicrobiologyUndergraduateantibiotic-resistancePCRgel electrophoresisauthentic inquiry

    1960

    views

    406

    downloads

    0

    comments

    0

    adaptations

    1994-Roland_Minton-A Progression of Projectiles-Examples from Sports
    There is a progression of complexity and issues in projectile motion modeling from no resistance, to resistance proportional to velocity, then to velocity squared,

    Keywords: sportsresistanceprojectilebaseballdraglinear resistancequadratic resistancetennis

    97

    views

    38

    downloads

    0

    comments

    0

    adaptations

    2012-Jambhekar-Breen-Extravascular Routes Of Drug Administration in Basic Pharamacokinetics
    This provides an excellent step-by-step of the physiology, construction of model, and notions like peak concentration as well as issues like lag time.

    Keywords: concentrationphysiologydrugslag timeExtravascularPharamacokineticspeak time

    148

    views

    41

    downloads

    0

    comments

    0

    adaptations

    Assessing in vivo Antimicrobial Activity Through the Analysis of Galleria mellonella Kaplan-Meier Plots
    Antimicrobials and their use in the treatment of bacterial infections are a fundamental lesson in all microbiology courses. Typically, cultivation-based methods are used to teach students about...

    Keywords: Antimicrobial TestingAntimicrobialsInvertebrate animal models

    1907

    views

    276

    downloads

    0

    comments

    0

    adaptations

    Luria-Delbruck
    These two workbooks model the evolution of phage resistance in a bacterial population under two alternative hypotheses.

    Keywords: ExcelphageResources @ ESTEEMLuria-Delbruckresistance

    1200

    views

    225

    downloads

    2

    comments

    0

    adaptations

    1-085-DrugBolus-ModelingScenario
    Given data on the concentration of a drug in the plasma of a human in mg/L at certain time intervals in hours can we determine the rate at which the drug leaves the plasma as well as the initial...

    Keywords: concentrationsum of square errorsbolusdrugrate constantadminister

    218

    views

    137

    downloads

    0

    comments

    0

    adaptations

    2012-Shargel-Yu-AccessPharmacy-Applied Biopharmaceutics and Pharmacokinetics
    Step by step formation of drug absorption models is shown with many good graphics of system and plots. Solutions are offered but no solution methods are shown.

    Keywords: Michaelis-MentenEnzymesubstratecompartmentpharmacokineticsrate constanturinary dataabsorption rate

    73

    views

    32

    downloads

    0

    comments

    0

    adaptations

    1-080-DrugAdministration-ModelingScenario
    A simple drug administration situation is modeled with only two observations.

    Keywords: decaybloodstreamdrugrate constantadminister

    173

    views

    92

    downloads

    0

    comments

    0

    adaptations

    7-010-MultipleDoses-ModelingScenario
    Two multiple dose drug administration regimens are offered. A drug is to maintain a certain level (above a set minimum and below a set maximum) in the blood stream and one regimen involves bolus...

    Keywords: drug discoverystep functiondoseDiracdrug administrationinverse Laplace Transformintraveneousbolussteady drip

    244

    views

    191

    downloads

    0

    comments

    0

    adaptations

    Antibiotic Resistance of Bacterial Soil Isolates and Biofilm Production
    In this lesson, learners will hear about research that focuses on bacterial antibiotic resistance and biofilm production. Students will see how antibiotic resistance is measured and interpret a...

    Keywords: graph interpretationmicrobiologybiofilmfmnantibiotic-resistanceBioGraphIrepresentation in STEM

    351

    views

    265

    downloads

    0

    comments

    0

    adaptations

    2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
    This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.

    Keywords: absorptioncompartmentbloodstreamplasmapharmacokineticspharmacodynamicstherapeutic concentration rangedrug dispositiondrug response

    91

    views

    53

    downloads

    0

    comments

    0

    adaptations

    5-022-ColdPill-ModelingScenario
    A model for the flow of a cold pill drug through the gastrointestinal compartment to the bloodstream compartment of a human subject is proposed. Students solve the system of differential equation...

    Keywords: ratesmedicinedrug discoverycompartmentcold pillgastrointestinalbloodstream

    216

    views

    116

    downloads

    0

    comments

    0

    adaptations

    Close

    Home

    Search