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- EGFR_Instructor.docx(DOCX | 4 MB)
- EGFR_Student.docx(DOCX | 3 MB)
- HW10PrepforLab.docx(DOCX | 107 KB)
- HW11BioimageInformPartI.docx(DOCX | 82 KB)
- HW12BioimageInformPart2.docx(DOCX | 192 KB)
- HW3ClassifyingCancerGenes.docx(DOCX | 221 KB)
- HW4egfr.docx(DOCX | 106 KB)
- HW6CRISPR.docx(DOCX | 145 KB)
- Cancer Discovery Activities | HHMI BioInteractive
- Sequencing HHMI BioInteractive Cancer Resources | HHMI BioInteractive
- License terms
Description
This activity explores a specific gene (egfr) that is mutated in certain cancers. Students will interpret primary data and protein structures to determine the molecular function of EGFR, how the drug gefitinib targets cancer, how, where and how often resistance mutations arise, and how doctors determine when to prescribe gefitinib. This activity can be completed inside or outside of class and is intended to expand upon the Gene Cards activities and lead into the Image Analysis activity; however, it can be assigned independently of these activities as well.
A full description of how this resource was implemented in the classroom is available on the BioInteractive Blog
Cite this work
Researchers should cite this work as follows:
- Basta, H. (2018). Drug screening and cancer resistance: EGFR Activity. HHMI BioInteractive FMN (2016), QUBES Educational Resources. doi:10.25334/Q45120