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Drug screening and cancer resistance: EGFR Activity

Author(s): Holly Basta

Rock Mountain College

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Summary:
This activity explores a specific gene (egfr) and its role in cancer. EGFR was introduced with the Gene Card Activities, researched throughout the semester, and then authentic image data of EGFR-mutated cells were analyzed.

Licensed under CC Attribution-NonCommercial-NoDerivatives 4.0 International according to these terms

Version 1.0.0 - published on 25 Jul 2018 doi:10.25334/Q45120 - cite this

Adapted from: Cancer Discovery Activities v 1.0

Keywords

  1. Resources @ HHMI - BioInteractive
  2. genomics
  3. cancer
  4. genetic basis of disease
  5. biology of cells

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Description

This activity explores a specific gene (egfr) that is mutated in certain cancers. Students will interpret primary data and protein structures to determine the molecular function of EGFR, how the drug gefitinib targets cancer, how, where and how often resistance mutations arise, and how doctors determine when to prescribe gefitinib. This activity can be completed inside or outside of class and is intended to expand upon the Gene Cards activities and lead into the Image Analysis activity; however, it can be assigned independently of these activities as well.

A full description of how this resource was implemented in the classroom is available on the BioInteractive Blog

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