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    How Do Kidneys Make Urine From Blood? Qualitative and Quantitative Approaches to Filtration, Secretion, Reabsorption, and Excretion
    The function of the kidneys is to help maintain a constant internal environment (homeostasis) by regulating the volume and chemical composition of the blood. This regulation occurs via three...

    Keywords: collecting ductexcretionglomerular filtration rate (GFR)nephron tubulereabsorptionrenal corpusclesection

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    Sequence Similarity in Developmental Biology - A Bioinformatics Exercise Using Myostatin
    This exercise leads upper level biology majors in an inquiry-based excursion to determine how similar the signaling molecule, myostatin, is between humans and mice, using a basic set of...
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    Cell Signaling Pathways - a Case Study Approach
    Signaling and gene expression are fundamental to cell biology and developmental biology. Although these topics are highly interrelated, they typically appear in separate units in a course. We use a...

    Keywords: signal transductiongene expressionCell communicationgenetic disordersregulation of enzyme activity

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    The ACTN3 Polymorphism: Applications in Genetics and Physiology Teaching Laboratories
    Inquiry-based undergraduate laboratories provide the opportunity to engage students in a research experience that improves scientific thinking, but such activities can be difficult to develop and...

    Keywords: protein structure and functionhuman genetic variationmuscle physiology

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    Why does Blood Flow Change? Investigating the Math of Blood Flow Dynamics
    This collection of activities explores the relationship between blood flow, pressure, and the factors of resistance through graphs and modeling direct and inverse variation.

    Keywords: quant biographingRatiosmathassessmentcollege algebraundergraduate educationphysiologyAnatomyhuman biologyvariationCardiovascular physiologyAnatomy & Physiologylab activityOpenStaxqbccmanipulate equationsUnderstanding fractionsChoosing modelsUnderstanding ratesEstimating answersUse elementary functionsCreate graphsInterpret graphsRates and ProportionsSolving Equations and Inequalities

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    Problem-Based Learning for Physiology: Synthesizing the Cardiovascular System, Respiration, Macronutrient Metabolism, and Renal Function
    Problem Based Learning (PBL) is a valuable tool for helping students overcome reliance on memorization by scaffolding opportunities for them to practice the competency of...

    Keywords: MetabolismObesityblood pressurecardiac functioncardiovascularmetabolic syndromerenalRespirationrespiratory system

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    The Science Behind the ACTN3 Polymorphism
    A common polymorphism in the alpha-actinin-3 (ACTN3) gene results in the lack of ACTN3 protein expression in fast twitch muscle fibers in ~16% of the human population (1). This genetic change has...

    Keywords: protein structure and functionhuman genetic variationskeletal muscle physiology

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    Tying it All Together: An Activity to Help Students Connect Course Experiences to Posted Learning Outcomes
    Instructors of undergraduate courses in Biology and other Science, Technology, Engineering, and Mathematics (STEM) disciplines face an ongoing challenge to foster higher-order thinking and learning...

    Keywords: metacognitionreflectiongoalsOutcomes

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    Introduction to Phylogenetic Trees for Comparative Genomic Analysis
    In this activity, students are introduced to phylogenetic trees and networks as tools for analyzing evolutionary relationships.
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    2012-Jambhekar-Breen-Extravascular Routes Of Drug Administration in Basic Pharamacokinetics
    This provides an excellent step-by-step of the physiology, construction of model, and notions like peak concentration as well as issues like lag time.

    Keywords: concentrationphysiologydrugslag timeExtravascularPharamacokineticspeak time

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    Antigen presentation and cytotoxic T lymphocytes (CTLs): elucidating a common roadblock for students
    Active learning resource for pre-Nursing anatomy and physiology lecture explaining antigen presentation to CTLs and how the CTLs recognize and destroy the pathogen using Biointeractive animations...

    Keywords: Resources @ HHMI - BioInteractiveimmune systemAnatomy & PhysiologyCell communication

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    Exploring Connections between Low Albedo, Urban Heat Islands and Social Justice
    This exercise explores circumstances of urban heat islands in the United States using spatial data, including an exploration of heat island solutions.

    Keywords: redliningUrban heat islandalbedo

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    Online exercise: Managing Prairie Dogs for Ferret Reintroduction: A Case Study
    This data-driven ‘ferret reintroduction’ exercise, adapted from https://www.sesync.org/printpdf/2264, was developed for undergraduate students in an online non-majors biology course as a final...
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    Exercise on "Globally endangered sea turtles of the Palmyra Atoll National Wildlife Refuge: A Focus on Scientific Analysis"
    This data-driven endangered sea turtle exercise adapted from http://qubeshub.org was developed for undergraduate students in an online non-majors biology course as a final small group project.

    Keywords: Resource Type

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    Electrical Activity of Neurons
    This tutorial describes how neurons generate action potentials, and how scientists measure neuronal activity and record the firing of individual neurons.

    Keywords: Resources @ HHMI - BioInteractiveAnatomy & PhysiologyNervous systemCell communication

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    List of models in which observed patterns are Important
    Supplemental material for ABM

    Keywords: textbookNetLogoagent-based modelingIndividual & Agent Based Modelingin-class activityproblem set

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    2006-Han-EtAl-Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology
    Physiologically-based pharmacokinetic (PBPK) models have been used to describe the distribution and elimination characteristics of intravenous ethanol administration.

    Keywords: liverwortsintraveneouspharmacokineticsethanolethanol infustionpharmacodynamictissue model

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    Regulation of Sex Determination
    This activity accompanies the HHMI BioInteractive module Sex Verification of Athletes (​https://www.hhmi.org/biointeractive/testing-athletes​). It provides students with exercises to explore the...
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    2007-Zenker-Rubin-Clermont-From inverse problems in mathematical physiology to quantitative differential diagnoses
    The improved capacity to acquire quantitative data in a clinical setting has generally failed to improve outcomes in acutely ill patients, suggesting a need for advances in computer-supported data...

    Keywords: physiologyinverse problem

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    Doctor in the House: Improving Undergraduate Critical Thinking Skills Through Diagnosing Medical Case Studies
    Students in undergraduate anatomy and physiology courses are not often exposed to clinical examples of homeostatic imbalances, particularly ones that provide an opportunity to diagnose a...

    Keywords: medicinediagnosiscardiovasculardeductive reasoningdigestiveEndocrinehomeostatic imbalancehypothetico-deductive modelurinary

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