You are here: Home / Resources / Browse Resources

Open. Adaptable. Free.

Resources created by our members and partners.

The QUBES platform hosts hundreds of teaching materials, reference materials, and cloud-based software free to use and adapt using open Creative Commons licenses.

Text Search:
Applied Filters
    An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure
    Gene structure, transcription, translation, and alternative splicing are challenging concepts for many undergraduates studying biology. These topics are typically covered in a traditional lecture...

    Keywords: bioinformaticsGenome BrowsergenomicsRNAseqsplicingComputer ModelGene Structure

    7272

    views

    1403

    downloads

    0

    comments

    0

    adaptations

    2008-Brewer-EtAl-Fitting ordinary differential equations to short time course data
    In this paper, we present a survey of existing algorithms and describe the main approaches. We also introduce and evaluate a new efficient technique for estimating ODEs linear in parameters...

    Keywords: time seriesEvaluation SPLINEgeneleast squaresbifurcation

    89

    views

    37

    downloads

    0

    comments

    0

    adaptations

    A Muscular Dystrophy Case Study Illustrating the Phenotypic Effects of Mutation
    Mutations in genes can lead to a variety of phenotypes, including various human diseases. Students often understand that a particular mutation in a single gene causes a disease phenotype, but it is...

    Keywords: mutationProtein Structureethicscentral dogmahuman disease

    2757

    views

    266

    downloads

    0

    comments

    0

    adaptations

    Studying phylogeny by producing phylogenetic trees of primates using morphological and molecular characteristics.
    An assignment constructing phylogenetic trees using shared, derived morphological traits and molecular differences among 18 primate species and two outlier species has been developed. Skull and...
    681

    views

    138

    downloads

    0

    comments

    0

    adaptations

    Splicing it Together: Using Primary Data to Explore RNA Splicing and Gene Expression in Large-Lecture Introductory Biology
    At the heart of scientific ways of knowing is the systematic collection and analysis of data, which is then used to propose an explanation of how the world works. In this two-day module, students...

    Keywords: gene regulationtranscriptiongene expressioncentral dogmarepressoralternative splicingmRNA processingActivatorTranscription factors

    3302

    views

    467

    downloads

    0

    comments

    0

    adaptations

    1-001a-MMDeathImmigration-Variation-ModelingScenario
    We model exponential death with m&m's as well as death with immigration.

    Keywords: simulationdatam&mimmigrationdeath

    460

    views

    228

    downloads

    0

    comments

    0

    adaptations

    4-039-FallingDarts-ModelingScenario
    we develop, solve, and analyze a second order differential equation model for free fall incorporating air resistance. Students solve the model using two methods -- reduction of order and...

    Keywords: optimizationresistanceterminal velocitymuzzle velocitydrag coefficientfree fallair drag

    253

    views

    288

    downloads

    0

    comments

    0

    adaptations

    6-067-LotkaVolterra-ModelingScenario
    This modeling scenario guides students through the process of fitting the Lotka-Volterra model of two differential equations to a real time series observational data. Students use the capabilities...

    Keywords: time seriesdatacompetitionLotka-Volterramodel fittingpredictiongauseRexperimental

    351

    views

    95

    downloads

    0

    comments

    0

    adaptations

    Making Predictions with Linear Models: A Murder Mystery Case Study
    This Swirl lesson will introduce two main concepts to students: 1) the idea of uncertainty around linear slopes versus individual values and 2) predicting values using linear models.

    Keywords: data visualizationlinear modelscase study teachinguncertaintypredictionConfidence intervals

    788

    views

    279

    downloads

    0

    comments

    0

    adaptations

    Big Data, Graphs, and Prediction
    In this activity, students are introduced to graphing and modeling data in a step-wise fashion. Real data of covid-19 deaths over time are used to incrementally ask students to fit the data to...

    Keywords: epidemiologygraphingLogarithmsexponential growthqbcccovidChoosing modelsCreate graphsInterpret graphsConcepts in Statistics

    1174

    views

    594

    downloads

    0

    comments

    0

    adaptations

    Does Organelle Shape Matter? Exploring Cell Shape through the Allen Cell Explorer and High-content Microscopy Datasets
    The morphology and localization of structures inside the cell are often assumed to fit the ideal images found in biology textbooks. This interrupted case study using high-throughput microscopy data...
    2033

    views

    3094

    downloads

    0

    comments

    0

    adaptations

    RNAseq data analysis using Galaxy
    This is a bioinformatics exercise intended for use in a computer lab setting with life science majors.

    Keywords: LabbioinformaticsNCBImappingUndergraduateworkflowNIBLSEGalaxyRNAseqgene expressionAdvancedExtended ProjectArabidopsisC1. Role of bioinformaticsC2. Computational conceptsC3. Statistical conceptsC5. Data retrievalIncubated at NIBLSEdifferentially expressed genes

    1457

    views

    214

    downloads

    0

    comments

    0

    adaptations

    Chapter 9: One-way analysis of variance
    Biostatistics Using R: A Laboratory Manual was created with the goals of providing biological content to lab sessions by using authentic research data and introducing R programming language....

    Keywords: biostatisticsR programming language

    917

    views

    532

    downloads

    0

    comments

    0

    adaptations

    Ethics in Synthetic Biology
    This collection of five activities provide students with an introduction to thinking about ethical concerns in human genome synthesis, gene editing, metabolic engineering, and synthetic genomes.

    Keywords: biostatisticsstatistical analysisavian malariaSummer Workshop 2018

    1024

    views

    222

    downloads

    0

    comments

    0

    adaptations

    Mini-Workshop August 14, 2020
    We reviewed the materials available on Genome Solver (other lessons here) and described our new python pipeline for examining horizontal gene transfer and a new synteny lesson in detail.

    Keywords: Bioinformatics Education

    1197

    views

    1887

    downloads

    0

    comments

    0

    adaptations

    Build-a-Genome Lab Manual for RFP Synthesis
    This lab manual describes a multi-week lab project for the design, assembly from oliognucleotides, cloning, and sequencing of the RFP gene. This resource was developed as part of NSF Award...
    822

    views

    465

    downloads

    0

    comments

    0

    adaptations

    Modeling the lac Operon to Understand the Regulation of Gene Expression in Prokaryotes
    This resource is a recitation activity designed for an introductory biology course in which students explore a lac operon simulation (https://qubeshub.org/resources/phetlacoperon).

    Keywords: simulationLac Operon

    1417

    views

    663

    downloads

    0

    comments

    0

    adaptations

    Web Popgen
    A Hardy-Weinberg simulation program.

    Keywords: Hardy-Weinbergpopulation geneticscomputer simulationsGenetic DriftmutationNatural Selection

    1946

    views

    318

    downloads

    0

    comments

    0

    adaptations

    The Great Petunia Carnage of 2017: A Clicker Case Study Using Petunias to Describe the Effect of Genetic Modification on the Biochemistry of Flower Color and Phenotype in Plants
    In this single class period case study, students examine the difference between genotype and phenotype by studying the mechanisms by which commercially available petunias have been bred to have...

    Keywords: case studyGenetic ModificationsBiochemistry of Flower ColorGMO regulationsGenotype-Phenotype Connections

    1026

    views

    9

    downloads

    0

    comments

    0

    adaptations

    2012-Brian_Ingalls-Mathematical_Modelling_in_Systems_Biology
    This text provides an introduction to dynamic mathematical modeling of cellular processes. The emphasis is on using computational tools to investigate models of cellular phenomena.

    Keywords: biologygene regulatory networksModelsmetabolic networkssignal transduction pathwayselectrophysiology

    110

    views

    39

    downloads

    0

    comments

    0

    adaptations

    Close

    Home

    Search