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    Fragile States: A Case Study Exploring Genetics, Molecular Biology, and Biochemistry Through the Lens of Fragile X Syndrome
    This case aims to strengthen students’ understanding of molecular biology concepts through study of Fragile X Syndrome (FXS). Students begin by learning the cause and phenotypes of FXS and...

    Keywords: gene regulationtranscriptiontranslationFragile X syndrometriplet repeat expansionsex linkagemetabolic pathway

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    A CRISPR/Cas Guide RNA Design In Silico Activity
    CRISPR biotechnologies inspired by the Clustered Regularly Interspaced Short Palindromic Repeat RNA-guided nuclease adaptive bacterial immune system have revolutionized biology research and become...

    Keywords: bioinformaticsgene expressiongenetic basis of diseaseCRISPR/Cas9genetic engineeringin silico

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    Why do Some People Inherit a Predisposition to Cancer? A small group activity on cancer genetics
    Before undergraduate students take a genetics course they generally know cancer has a genetic basis and involves the proliferation of cells; however, many are uncertain about why only a subset of...

    Keywords: cancerInheritance patternsProbability calculationProto-oncogeneTumor Suppressor Gene

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    Colon Cancer: A Case of Genetic Bad Luck
    Case study developed for an introductory genetics class published in the National Center for Case Study Teaching in Science

    Keywords: bioinformaticsNCBINIBLSEBLASTPublished in National Center for Case Study Teaching in Sciencecolon cancerpedigreegenetic testingAPC

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    Exploring Population Change without Selection: Avida-Ed Lab Book Exercise 4
    An introductory activity exploring how a population changes without natural selection using the Avida-ED simulation.

    Keywords: population geneticsEvolutionavida-edsoftware simulationsSelection

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    Exploring the Introduction of Genetic Variation by Random Mutation: Avida-Ed Lab Book Exercise 1
    An introductory activity introducing the role of random mutation in generating genetic variation using the Avida-ED simulation.

    Keywords: geneticsEvolutionavida-edmutationsoftware simulations

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    Processes that Regulate Patterns of Species and Genetic Diversity - Intro Environmental Science
    This activity was adapted for use in an intro non-majors Environmental Science course, with an emphasis on collaborative data collection.

    Keywords: data analysisGenetic Driftquantitative skillsspecies diversityIsland biogeographygamificationgenetic diversityecological driftcolonizationcollaborative data collection

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    Phylogenetic analysis using collections material: interpreting trait evolution by comparison of morphological and molecular genetic hypotheses
    Exercise spans two weeks, includes homework, and involves some groups of animals as well as plants. Emphasizes re-interpretation of morphological trait evolution following molecular genetic...

    Keywords: Evolutionmorphologyphylogenylaboratoryplantsbiological collectionsmolecular analysis

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    How to Find a Gene: Retrieving Information From Gene Databases
    A strong understanding of distinct gene components and the ability to retrieve relevant information from gene databases are necessary to answer a diverse set of biological questions. However, often...

    Keywords: NCBItranscriptiontranslationGene StructureGene databasesEnsembl

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    What is Speciation, How Does It Occur, and Why Is It Important for Conservation?
    Speciation provides a framework for classifying biodiversity on Earth and is a central concept in evolutionary biology. To help undergraduate students learn about speciation, we designed a...

    Keywords: EvolutionconservationGenetic DriftSpeciationNatural SelectionBiological species conceptgene flowMorphological species conceptPhylogenetic species concept

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    More information about the Discovery – Doing Science Biology Education Conference
    2023 Conference Theme - Variants in Biology Education: What can we learn from pandemics?

    Keywords: LDC2023

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    Predicting and classifying effects of insertion and deletion mutations on protein coding regions
    Mutations in genes can affect the encoded proteins in multiple ways, and some of these effects are counterintuitive. As for any other knowledge, students must create their own deep understanding of...

    Keywords: mutationcentral dogmatranslationframeshift

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    Behavioral Genetics: Investigating the genes of a complex phenotype in fruit flies
    Introductory genetics laboratory published as GSA Learning Resource

    Keywords: behaviorbioinformaticsNIBLSEdrosophilagenetic basisfruit fliesmodel organism

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    Deme 2.0
    This workbook simulates the population genetics of a single gene with two alleles. It can simultaneously model up to three local populations, which may differ in their selection coefficients.

    Keywords: population geneticsGenetic DriftNatural Selection

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    A 360˚ View of COVID-19
    In March 2020, institutions underwent a massive transition to distance learning as a result of the COVID-19 pandemic. With so little time to devise new materials to maximize learning in the new...

    Keywords: geneticsImmunologyBiochemistrybioinformaticsmolecular evolutionpublic healthvirusCOVID19

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    Central Dogma, Dictionaries, and Functions: Using Programming Concepts to Simulate Biological Processes
    Technologies like next-generation sequencing, proteomics, and high-throughput phenotyping have transformed the way we do biology. There is a continued need for scientists with computational skills...

    Keywords: computationpythonJupyter notebookFunctionscentral dogmaDictionaries

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    The ACTN3 Polymorphism: Applications in Genetics and Physiology Teaching Laboratories
    Inquiry-based undergraduate laboratories provide the opportunity to engage students in a research experience that improves scientific thinking, but such activities can be difficult to develop and...

    Keywords: protein structure and functionhuman genetic variationmuscle physiology

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    SKILLS DEVELOPMENT - Toxicology MSDT
    On this website you can find 6 learning modules on various topics in toxicology. These are self-paced student-centered online learning modules. You will receive a certificate of completion at the...

    Keywords: pathophysiologyregulatory toxicologyprinciples of toxicologybiochemistry and molecular geneticsprinciples of genetic toxicologyapplied systems toxicology

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    Using Bioinformatics to Understand Genetic Diseases: A Practical Guide
    This Practical Guide outlines a number of basic bioinformatics approaches that can be used to understand the molecular basis of genetic diseases.
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    Sickle Cell Disease and Natural Selection in Humans
    A short film explores the evolutionary connection between an infectious disease, malaria, and a genetic condition, sickle cell anemia. The animation explores the genetic causes and biological...

    Keywords: HHMI BioInteractive

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