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    The p53 Gene and Cancer
    This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer.

    Keywords: Resources @ HHMI - BioInteractiveBiochemistrymolecular biologymacromoleculesGenetic disease

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    Cancer Discovery Activities
    These two hands-on activities are based on a Howard Hughes Medical Institute 2013 Holiday Lectures on Science video (http://www.hhmi.org/biointeractive/cancer-genetic-disease-video-highlights)...

    Keywords: geneticsResources @ HHMI - BioInteractiveorganismal biologyneurosciencegenomicscancergenetic basis of diseasebiology of cellsHigh School

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    Mapping a Mutation to its Gene: The "Fly Lab" as a Modern Research Experience
    Although genetics is an invaluable part of the undergraduate biology curriculum, it can be intimidating to students as well as instructors: Students must reduce their reliance on memorization and...

    Keywords: geneticsbioinformaticsdrosophilachi-square analysiscomplementation mappingmode of inheritancethree-point mapping

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    GMC: Genes, Mutations and Cancer - Group Concept Map Development
    It has been shown that active learning strategies used in the classroom can increase student learning and retention of information. We generated an active learning exercise that can be used in the...

    Keywords: mutationcancerCell Division

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    BLAST-HGT PROJECT
    Genome Solver modules were combined to make one project for students using tools within NCBI BLAST to explore phylogenetics and horizontal gene transfer from phage to Chlamydia.
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    Lesson III - Annotation
    Genome Solver began as a way to teach undergraduate faculty some basic skills in bioinformatics; no coding or scripting is required. Lesson III introduces Annotation, or assigning meaning to all...

    Keywords: Bioinformatics EducationBioinformatics and Genomics

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    Exploring the evolution of caffeine biosynthesis enzymes
    Caffeine is a very common stimulant consume worldwide as tea, coffee, mate, cocoa, and chocolate. Ever wondered why plants make caffeine? Do all caffeine producing plants have the same enzymes for...

    Keywords: Bioinformatics EducationBioinformatics and Genomics

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    Amylase Copy Number and Diet
    An adapted module from HHMI Spreadsheet Tutorials using amylase data for students to gain data analysis and excel skills

    Keywords: Scientific ProcessStatistics and MathScientific Methodology

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    Evolution of Tusklessness in African Elephants
    The exploitation of African elephants in the form of ivory poaching is exacerbated by warfare. The affects of this anthropogenic evolutionary force on the African savanna elephant (Loxodonta...

    Keywords: Hardy-Weinbergchi-squaredEvolutionExponentsRatiospercentselephantsGorongosa National ParkAfricaqbccUnderstanding fractionsSolving Equations and InequalitiesConcepts in Statisticsusing statisticstusk & tusklessIvory poachingFractions and Mixed NumbersDecimals

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    An Interactive Protocol for In-Classroom DNA Extraction
    Using commonly available materials, this tool allows students to extract DNA, exploring DNA chemistry and the principles of experimental design and execution. We take a “Choose Your Own...

    Keywords: geneticsDNAbiochemical structure and function

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    Necessary and Sufficient? Solving the Mystery of the Mitochondrial Pyruvate Transporter
    While there are several available lessons for teaching introductory biology students about diffusion, facilitated diffusion, and active transport, fewer materials exist to support upper-division...

    Keywords: DiffusionActive transportfacilitated diffusionNecessary and sufficientTransport proteins

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    UDL Guidelines Workbook
    A tool for analyzing a resource's alignment to CAST's Universal Design for Learning Guidelines
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    Using genome browsers constructed by G-OnRamp to provide students with a Course-based Undergraduate Research Experience in genome annotation
    G-OnRamp (http://g-onramp.org) provides an easy-to-use web platform for educators to create genome browsers to engage undergraduate students in research projects, both collaborative annotation of...
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    Meiosis Remodeled: Inclusion of New Parts to Poppit Bead Models Enhances Understanding of Meiosis
    A long-standing tradition uses strings of poppit beads of different colors to model meiosis, especially to show how segments of paired homologous chromosomes are recombined. Our use of orthodontic...

    Keywords: meiosischiasma formationchromosome recombination

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    Fragile States: A Case Study Exploring Genetics, Molecular Biology, and Biochemistry Through the Lens of Fragile X Syndrome
    This case aims to strengthen students’ understanding of molecular biology concepts through study of Fragile X Syndrome (FXS). Students begin by learning the cause and phenotypes of FXS and...

    Keywords: gene regulationtranscriptiontranslationFragile X syndrometriplet repeat expansionsex linkagemetabolic pathway

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    Lesson II - Databases
    Genome Solver began as a way to teach undergraduate faculty some basic skills in bioinformatics; no coding or scripting is required. Lesson II introduces the principal databases for microbial...

    Keywords: Bioinformatics EducationBioinformatics and Genomics

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    Examining the Physiology Behind the Symptoms of Lactose Intolerance
    This is a set of extension questions for the HHMI short film The Making of the Fittest: Got Lactase? The Co-evolution of Genes Video Activity.
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    HHMI SEA-PHAGES and GENES: Course-based UREs Designed for All
    The HHMI Science Education Alliance (SEA) program supports a community of faculty members and institutions embed research as a fundamental component of early undergraduate science curricula.

    Keywords: course-based research experiences (CUREs)SEA-PHAGES

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    Lesson IV - Comparative Genomics
    Genome Solver began as a way to teach undergraduate faculty some basic skills in bioinformatics; no coding or scripting is required. Lesson IV, Comparative Genomics, discusses some of the tools...

    Keywords: Bioinformatics EducationBioinformatics and Genomics

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    DNA Subway Learning Resources
    DNA Subway is a NIBLSE Recommended resource. This is a collection of learning resources associated with DNA Subway.

    Keywords: phylogeneticsIntroductoryLabbioinformaticsUndergraduateNIBLSEDNA BarcodingDNA sequenceBLASTmultiple sequence alignmentDNA SubwayInstructional SettingAudience LevelAdvancedActivity LengthExtended ProjectC1. Role of bioinformaticsC2. Computational conceptsC4. Bioinformatics toolsC5. Data retrievalC8. Data types

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