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    Translating Co-Translational Translocation
    Understanding the process of proteins targeting to specific locations within a cell is a fundamental part of cell biology. Synthesis of proteins by co-translational translocation, which also...

    Keywords: Topologyco-translational translocationendoplasmic reticulumprotease protection assaysecretory proteinssignal sequencetransmembrane proteins

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    COVID-19: On the way to a vaccine
    This multi-part case study introduces the reader to the SARS-CoV-2 virus origins, the molecular basis of the infection, the development and severity of symptoms, and treatment.

    Keywords: BLASTprotein structure modelingmolecular visualization and analysisCOVID19PDB

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    Understanding COVID-19 Biology to Design a Vaccine
    This multi-part case study introduces the reader to the SARS-CoV-2 virus, replication, and treatment. Additional worksheets introduce students to bioinformatics tools of 3-D protein visualization...

    Keywords: BLASTprotein structure modelingmolecular visualization and analysisCOVID19PDB

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    COVID-19: Molecular Basis of Infection
    This case was written in Spring 2020 during the COVID-19 pandemic. It focuses on understanding the structure and interaction of the SARS-Cov-2 viral spike protein that facilitates infection in...

    Keywords: infectionvaccinemolecular visualization and analysisCOVID19PDBSARS-CoVMolecular Case Study

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    Pick Your Poison: A Semester-Long Case Study for Undergraduate Toxicology
    The ability to collate information from diverse scientific resources and effectively employ scientific writing is an essential skill for scientists. This lesson describes a semester-long project...

    Keywords: risk assessmenttoxicologyPharmacologyregulationsdose responseADME

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    Necessary and Sufficient? Solving the Mystery of the Mitochondrial Pyruvate Transporter
    While there are several available lessons for teaching introductory biology students about diffusion, facilitated diffusion, and active transport, fewer materials exist to support upper-division...

    Keywords: DiffusionActive transportfacilitated diffusionNecessary and sufficientTransport proteins

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    Implementing active learning approaches into an upper-division biology course
    In this essay, we present our strategy for implementing active learning strategies into an upper division course on Human Genetics. Our principal goal was to shift from a traditional didactic...

    Keywords: human biologyPedigree analysisRare genetic diseases

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    1-078-MonodGrowthModel-ModelingScenario
    Students model growth of bacteria E. coli in a limiting nutrient environment using data from a historical study.

    Keywords: bacterianutrient cyclesgrowthMonodconsumption

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    2015-Heiko_Enderling-Integrating experimental data to calibrate quantitative cancer models
    For quantitative cancer models to be meaningful and interpretable the number of unknown parameters must be kept minimal. We focus on a tumor hierarchy of cancer stem and progenitor non-stem cancer...

    Keywords: cancertumorfittingagent-based

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    2015-G_Knott-Chemical Kinetics - Simple Binding F + G to and from B
    The study of this reaction, F + G goes to and from B, is common in chemistry and biochemistry. For example, F could be a hormone or drug and G the associated receptor sites.

    Keywords: bindingreactionchemical kineticsdeterministicBiochem Labsprobabilistickinetic reaction

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    2011-Therese-Keane-Combat modelling with partial differential equations
    We present work seeking to more realistically represent troop dynamics and to enable a deeper understanding of the nature of conflict.

    Keywords: Lanchester modeltroop dynamicsswarming behaviortroop regroupinglossesnon-local termslocal terms

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    2008-Padir-EtAl-Teaching Differential Equations in a Diverse Classroom
    The interesting portion of this paper are the descriptions of student projects offered: Vibrations of a 3-Story Building in an Earthquake, Triple Pendulum, Nonlinear Circuit. Phase portraits were...

    Keywords: circuitearthquakevibrationpendulumbuikldingtriple pendumlumnonlinear circuit

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    2006-TK_Kar-Controllability and optimal harvesting of a prey–predator model incorporating a prey refuge
    This paper deals with a prey–predator model incorporating a prey refuge and harvesting of the predator species.

    Keywords: survivalpredator-preyharvestrefugePontryagin’s maximal principlehidingoptimal harvest

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    2005-JC_Sprott-Dynamical Models of Happiness
    A sequence of models for the time evolution of one’s happiness in response to external events is described.

    Keywords: happinessoscillation

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    1987-Claude-Marmasse-Studies on differential equations of enzyme kinetics-Biomolecular scheme
    The integral curve is compared with the solutions given by the two classical approximations to the problem: it is shown that the steady-state approximation is to be preferred to the rapid...

    Keywords: steady-state modelisoclinesenzyme kinetics

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    1994-S_S_Everingham-C_Peter_Rydell-Modeling the Demand for Cocaine
    This is a report prepared for the Office of National Drug Control Policy of the United States Army by the Rand Corporation. The report contains lots of data and builds a two compartment difference...

    Keywords: drugstwo compartmentcocainedemand

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    1989-Protopopescu-Santoro-Dockery-Combat modeling with partial differential equations
    We propose an extension of the classical modeling of combat via Lanchester equations to include one-dimensional spatial effects.

    Keywords: combatLanchester

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    5-001-LSD-ModelingScenario
    We describe the use of a two compartment model of a linear system of first order linear differential equations to model lysergic acid diethylamide (LSD) in the body. We provide the data from the...

    Keywords: LSDSpanishcompartmentpharmacokineticslysergic acid diethylamide

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    5-010-MatrixExponential-TechniqueNarrative
    The matrix exponential is a powerful computational and conceptual tool for analyzing systems of linear, constant coefficient, ordinary differential equations (ODE's). This narrative offers a quick...

    Keywords: matrix esponentialPutzer's Algorithmdiagonalizationeigenvalueseigenvectors

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    1-138-InnerEarDrugDelivery-ModelingScenario
    Students examine local drug delivery to the cochlea. The delivery system is modeled as a liquid mixing problem. Students formulate the differential equation, and solve the equation using separation...

    Keywords: concentrationdrug deliveryinner earcochleahearing loss

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