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    Does Organelle Shape Matter? Exploring Cell Shape through the Allen Cell Explorer and High-content Microscopy Datasets
    The morphology and localization of structures inside the cell are often assumed to fit the ideal images found in biology textbooks. This interrupted case study using high-throughput microscopy data...
    2010

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    Robot vs. Disease: Using CellProfiler to model biomedical research in your classroom
    Resource from the 2015 BioQUEST Summer Workshop

    Keywords: image analysisCellProfilerfluorescence microscopymicroscopycellular analysis

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    430

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    Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging
    Organelle structure has been studied and visualized for decades; however, publicly available databases that use improved high-throughput microscopy of gene-edited cell lines have recently...

    Keywords: modelingcase studymicroscopystructureOrganellesHigh-throughput (HT)Endoplasmic Reticulum (ER)Fluorescent microscopyHuman Cell Biology

    4484

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    2018-Robert_Phair-Differential_equation_methods_for_simulation_of_GFP_kinetics_in_non–steady_state_experiments
    Here, we derive new tracer kinetic analytical methods for non–steady state biological systems by constructing mechanistic nonlinear differential equation models of the underlying cell biological...

    Keywords: protein quality controlkineticsCellssteady statechemical kineticsfluouresencephotoactivationinytracellular

    228

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    36

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    Enhancing the Microscopy Skills of Non-Science Majors and Nursing Microbiology Students: Promoting the Practice of Observing Multiple Fields of View Using Blood Smear Slides
    One of the challenges in teaching microscopy is having students scan multiple fields of view at high power magnification. Many times, students will feel this unnecessary, especially when presented...

    Keywords: Microscopy SkillsBlood SmearsBlood Disorders

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    Using Immunocytochemistry and Fluorescence Microscopy Imaging to Explore the Mechanism of Action of Anti-Cancer Drugs on the Cell Cycle
    Understanding and visualizing the cell cycle and mitosis is an essential concept of cell biology. This multi-week lab module has students investigate the mechanism of action of anti-cancer drugs...

    Keywords: fluorescence microscopymitosisCell StructureCell ImagingImmunocytochemistryQuantitative microscopySTEM skills

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    Probing Subunit Interactions in 3-Phosphoglycerate Dehydrogenase
    A research poster.

    Keywords: JoCURE

    158

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    24

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    CUNEL - Connectomes for Undergraduate Neuroscience Education and Learning (RCN-UBE Introduction)
    The Connectomes for Undergraduate Neuroscience Education and Learning (CUNEL) project seeks to bring cutting-edge neuroscience methods into undergraduate classrooms and laboratories in order to...

    Keywords: RCN-UBE Introduction

    492

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    61

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    Simple, Accessible River-Based Field Investigation of Riverine Microplastics
    Scientists have discovered that microplastic pollution is ubiquitous in the environment, but the small size of these microscopic pollutants prohibits most people from recognizing their prevalence....

    Keywords: environmental sciencemicroplastic pollutionurban waterswasteenvironmental studiesfield-based learningfreshwater ecologywater qualityRiversSingle-use plasticfreshwater sciencewater ecologyField ExperiencesRiver Ecologyfield workThe Scientific MethodRiver Field Studies Networkfield courses

    649

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    441

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    HITS: A network to create inquiry-based case studies that make high-throughput approaches and discovery accessible
    HITS brings together interdisciplinary groups of HT researchers and instructors to produce authentic HT case studies that can be implemented in a variety of courses, allowing students to analyze...

    Keywords: case studieshigh-throughputHITS

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    COVID-19: On the way to a vaccine
    This multi-part case study introduces the reader to the SARS-CoV-2 virus origins, the molecular basis of the infection, the development and severity of symptoms, and treatment.

    Keywords: BLASTprotein structure modelingmolecular visualization and analysisCOVID19PDB

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    Understanding COVID-19 Biology to Design a Vaccine
    This multi-part case study introduces the reader to the SARS-CoV-2 virus, replication, and treatment. Additional worksheets introduce students to bioinformatics tools of 3-D protein visualization...

    Keywords: BLASTprotein structure modelingmolecular visualization and analysisCOVID19PDB

    1657

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    2010

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    HITS: A network to promote high-throughput (HT) approaches through inquiry-based case studies
    Poster on the HITS project presented at the 2018 Annual Fall Conference for the National Center for Case Study Teaching In Science.

    Keywords: case studiesbig dataHITSHigh-throughput Discovery Science & Inquiry-based Case Studies for Today’s StudentsAnnual Fall Conference for the National Center for Case Study Teaching In ScienceBuffalo case studyHigh-throughput (HT) approaches

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    HITS: A network to create inquiry-based case studies that make high-throughput approaches and discovery accessible
    Poster on the work of the NSF-funded High-throughput Discovery Science & Inquiry-based Case Studies for Today’s Students (HITS) Research Coordination Network. Presented at the 2021 BIOME Institute.

    Keywords: case studieshigh-throughputHITSHigh-throughput Discovery Science & Inquiry-based Case Studies for Today’s Students2021 BIOME

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    Understanding the Importance of Microtubules in Normal Cell Division: Chemotherapy Connection
    In introductory courses, students learn about microtubules as important structures but may not engage in a hands-on experience to localize microtubules themselves or to learn about their connection...

    Keywords: cancerCell DivisionimmunofluorescenceMicrotubulesAntibodies

    857

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    51

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    A Laboratory Module That Explores RNA Interference and Codon Optimization Through Fluorescence Microscopy Using Caenorhabditis elegans
    Scientific research experiences are beneficial to students allowing them to gain laboratory and problem-solving skills, as well as foundational research skills in a team-based setting. We designed...

    Keywords: microscopyC. elegansquantitative analysisinquiry-based learninggene expressionRNA interferenceCodon UsageLaboratory Module

    2433

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    169

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    Investigating the Function of a Transport Protein: Where is ABCB6 Located in Human Cells?
    One of the challenges of teaching Cell Biology is helping students understand important research methods used to study cells.  The goal of understanding cell biology methods is especially...

    Keywords: ABC transporter familyDifferential centrifugationImmunoblottingImmunofluorescence assayProtein localizationPurifying organellesSDS-PAGE

    1375

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    506

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    Fatty Acid Induction of Lipid Droplets in Cancer Cells
    There is a growing need for the development and communication of cell culture-based laboratory activities specifically designed for undergraduate students. This multi-week laboratory activity...

    Keywords: Course based undergraduate researchCell ImagingLive Cell Staining

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    Video Making Tips for Laboratory Instructors
    Demonstration videos are an excellent way to introduce students to new laboratory techniques, but many available videos are of low quality, too long, lack human diversity, and the main narrator is...

    Keywords: microscopypipettingLab Equipment

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    Nanoparticles and Shrimp: An Interdisciplinary Lab Series in Chemistry and Biology for Undergraduate Engineering Students
    The parallels between engineering and science are vast, as both disciplines apply theory and inquiry to solve complex problems. In order to prepare students for interdisciplinary careers in STEM,...

    Keywords: microscopychemistry applications in biologytoxicity

    1470

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    164

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