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    Introduction to Mathematical Modeling in Biotechnology, Cell Biology, and Physiology
    The course is a mathematical and computational exploration of five diverse areas of biology: human locomotion, gene sequence analysis, signal transduction pathways involved in cancer,...

    Keywords: mathematical modelingcoursehuman locomotionneuroanatomyneurophysiologysignal transductiongene sequence analysis

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    Translating Co-Translational Translocation
    Understanding the process of proteins targeting to specific locations within a cell is a fundamental part of cell biology. Synthesis of proteins by co-translational translocation, which also...

    Keywords: Topologyco-translational translocationendoplasmic reticulumprotease protection assaysecretory proteinssignal sequencetransmembrane proteins

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    Module 2: Transcription Part I: From DNA Sequence to Transcription Unit
    This module illustrates how a primary transcript (pre-mRNA) is synthesized using a DNA molecule as the template. Students will learn about the importance of the 5' and 3' regions of the gene for...

    Keywords: data visualizationmolecular biologybioinformaticsGenome BrowsergenomicsTranscription InitiationTranscription Start SiteTranscription Termination Signal

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    Protein Import Into the ER: Understanding Experimental Methods for Old and New Cellular Discoveries
    Process Oriented Guided Inquiry Learning (POGIL) is an effective approach for group work in STEM courses. POGIL-style lessons foster active learning because they require students to communicate and...

    Keywords: Necessary and sufficientsignal sequenceProtein SynthesistrafficER importTranslocation

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    Dynamic Programming
    In bioinformatics, dynamic programming is mainly used to align nucleotide and amino acid sequences, and to predict RNA and protein folding from primary sequence data.

    Keywords: RNAamino acid sequenceSequence alignmentdynamic programmingprotein folding

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    Learning About Protein Localization: A Lesson for Analyzing Figures in a Scientific Publication
    In order to function correctly, proteins must be localized to a specific subcellular location. We have designed this lesson to use data from the primary literature to teach students about the...

    Keywords: colocalizationimmunofluorescenceProtein localizationsignal sequencessubcellular fractionationwestern blotting

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    Meiosis: A Play in Three Acts, Starring DNA Sequence
    Meiosis is well known for being a sticky topic that appears repeatedly in biology curricula. We observe that a typical undergraduate biology major cannot correctly identify haploid and diploid...

    Keywords: recombinationmeiosisDNA sequenceCrossingoverchromosome structureHolliday junctionhomology

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    Sequence Similarity: An inquiry based and "under the hood" approach for incorporating molecular sequence alignment in introductory undergraduate biology courses
    This laboratory module, published on CourseSource, leads introductory biology students in the exploration of a basic set of bioinformatics concepts and tools.

    Keywords: phylogeneticsbioinformaticssequencingFASTANCBINIBLSEalgorithmsincubatorsBLASTmultiple sequence alignmentsequence similarityBLOSUM scoring matrixneighbor-joining distance matrixCourseSourcephylogramZika virus

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    2012-Brian_Ingalls-Mathematical_Modelling_in_Systems_Biology
    This text provides an introduction to dynamic mathematical modeling of cellular processes. The emphasis is on using computational tools to investigate models of cellular phenomena.

    Keywords: biologygene regulatory networksModelsmetabolic networkssignal transduction pathwayselectrophysiology

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    1-096-OP-AMP-Differentiator-ModelingScenario
    The output waveform (function) of a operational amplifier type of differentiator circuit is determined analytically from the first order governing ordinary differential equation and compared with...

    Keywords: simulationMeasurementfeedbackMultisimcircuitvoltageoperational amplifiervalidationSPICE

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    Investigating Cell Signaling with Gene Expression Datasets
    Modern molecular biology is a data- and computationally-intensive field with few instructional resources for introducing undergraduate students to the requisite skills and techniques for analyzing...

    Keywords: genomicstranscriptionsignaling

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    Introductory Video and worksheets on Module 1 and 2 on "Sequence Similarity: An inquiry based and under the hood..."
    The video walks the students to complete Module 1 and 2 on Sequence Similarly and Alignment adapted from Tapprich (2019) and Hudson Alpha that teaches these modules within the context of the...

    Keywords: bioinformaticssequencingFASTANCBINIBLSEalgorithmsBLASTmultiple sequence alignmentsequence similarityBLOSUM scoring matrixCourseSource

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    Protein Analysis
    This Excel workbook allows the analysis of sample or imported protein sequences. The model can analyze protein sequences up to 500 amino acids long.

    Keywords: Protein sequencehydrophobicity/hydrophilicity

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    Sequence Similarity: A Quick Introduction to Bioconductor
    Following the Sequence Similarity exercises by Kleinschmit, et al., this tutorial will guide students in using the Bioconductor suite of R packages to likewise compute sequence similarity.

    Keywords: bioinformaticssequencingNIBLSEmultiple sequence alignmentsequence similarityBLOSUM scoring matrixBioconductor

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    Spectral Seismology Module (Project EDDIE)
    Based on a conceptual presentation of waveforms and filters

    Keywords: Project EDDIE

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    Sequence Similarity: Introducing Biological Databases to Community College Biology Students
    This laboratory module, published on CourseSource, leads introductory biology students in the exploration of a basic set of bioinformatics concepts and tools.

    Keywords: phylogeneticsbioinformaticssequencingFASTANCBINIBLSEalgorithmsincubatorsBLASTmultiple sequence alignmentsequence similarityBLOSUM scoring matrixneighbor-joining distance matrixCourseSourcephylogramZika virus

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    Bioinformatics: the Power of Computers in Biology – a Practical Guide
    This Practical Guide in the Bringing Bioinformatics into the Classroom series introduces simple bioinformatics approaches for database searching and sequence analysis.

    Keywords: NIBLSEGOBLET

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    2019-Stender_EtAl-Recovery_Of_Differential_Equations_From_Impulse_Response
    In this work, a recent method, which allows reconstructing differential equations from time series data, is extended for higher degrees of automation.

    Keywords: time seriesregressionresponseimpulseoscillationsignal processingsparse regressionsystem identification

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    DNA Subway Learning Resources
    DNA Subway is a NIBLSE Recommended resource. This is a collection of learning resources associated with DNA Subway.

    Keywords: phylogeneticsIntroductoryLabbioinformaticsUndergraduateNIBLSEDNA BarcodingDNA sequenceBLASTmultiple sequence alignmentDNA SubwayInstructional SettingAudience LevelAdvancedActivity LengthExtended ProjectC1. Role of bioinformaticsC2. Computational conceptsC4. Bioinformatics toolsC5. Data retrievalC8. Data types

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    Sequence Similarity in Developmental Biology - A Bioinformatics Exercise Using Myostatin
    This exercise leads upper level biology majors in an inquiry-based excursion to determine how similar the signaling molecule, myostatin, is between humans and mice, using a basic set of...
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