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    1999-Khorasheh-Ahmadi-Gerayeli-Application of Direct Search Optimization for Pharmacokinetic Parameter Estimation
    For simple pharmacokinetic compartmental models, analytical solution to the governing differential equations provide a mean to evaluate the associated rate constants. Such methods, however, can not...

    Keywords: sum of square errorsleast squarespharmacokineticslineteicscompartmental modelsdirect search

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    6-029-TumorGrowth-ModelingScenario
    This modeling scenario guides a student familiar with single ordinary differential equation (ODE) models towards the development of a more complex system of two ODEs for describing the evolution of...

    Keywords: Pop_Growth Pilotlogisticcomparmenttumorsynthetic datasum of squares error

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    Spreadsheet Tutorial 2 - Autofill Data, Cell References, and Standard Deviation
    Generate a table with autofill, and use absolute cell reference to calculate variance and standard deviation.

    Keywords: Resources @ HHMI - BioInteractiveScientific ProcessStatistics and MathScientific MethodologyHigh School

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    1984-W_Brunner-D__Focht-Deterministic Three-Half-Order Kinetic Model for Microbial Degradation
    The kinetics of mineralization of carbonaceous substrates has been explained by a deterministic model which is applicable to either growth or nongrowth conditions in soil.

    Keywords: kineticsnonlinear regressionsum of square errorsMonodlinearizemineralizationsubstratescarbonaceous

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    5-080-SpaceFlightRecolonize-ModelingScenario
    This project is a combination of differential equations, multi-variable calculus, and vector calculus with use of technology to model colonization of a new planet. Students solve a system of...

    Keywords: optimizationsum of square errorsvector calculusLagrange multipliersline integrals

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    Spreadsheet Tutorial 3 - Column Graphs, Error Bars, and Standard Error of the Mean
    Generate a column or bar graph with standard error bars.

    Keywords: Resources @ HHMI - BioInteractiveScientific ProcessStatistics and MathScientific MethodologyHigh School

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    Math Bench Probability and Statistics: Mice with Fangs - Intro to Punnett Squares
    This is an online activity that provides an introduction to Punnett squares as a tool for visualizing genetic inheritance. The ratios of possible genotypes and phenotypes in offspring are...

    Keywords: geneticsResources @ MathBenchonlineMathBenchpunnett squares

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    More Mice with Fangs: Intermediate Punnett Squares
    An online module utilizing probability and Punnett squares to introduce students to more complex genetic problems. The module emphasizes students' use of probability to solve the problems.

    Keywords: geneticsProbabilityResources @ MathBenchonlinepunnett squares

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    Linked Genes and Recombination: Advanced Punnett Squares
    An online module in which students learn about more difficult genetics problems, including linked genes and crossing over. Quantitatively students learn about marginal probabilities and chi-square...

    Keywords: geneticsProbabilityResources @ MathBenchonlinepunnett squareslinked genes

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    3-090-OneSpringMass-ModelingScenario
    We lead students through building a mathematical model for a single mass (bob)-spring system that is hanging vertically. We also lead the students, using data that they collect together with their...

    Keywords: undampedsum of square errorsmass springHooke's Lawoscilationleast-squares approximation

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    8-002-TrigSumRepresentation-TechniqueNarrative
    Students discover how to represent functions as sums of trigonometric functions and the value of such representations in many fields. This is an introduction to the study of Fourier Series.

    Keywords: estimationTrigonometryTrigonometric Functionssum of square errorsfinite sumFourier seriesFouriere sumspectrumapproximatiopn

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    2015-Zhang-EtAl-On the Selection of ODE Models with Application to Predator-Prey Dynamical Models
    We propose a computationally inexpensive approach that employs statistical estimation of the full model, followed by a combination of a least squares approximation (LSA) and the adaptive Lasso.

    Keywords: least-squares approximationSpline modelingMonte Carlo simulationsvariable selectionadaptive LASSO

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    1975-Rodda-Sampson-Smith-The One-Compartment Open Model Parameter Estimation
    A new estimation procedure is proposed for estimating the parameters of the simplest pharmacokinetic model, the one-compartment open model.

    Keywords: compartment modelpharmacokineticsnonlinear estimationone compartment model

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    1991-JR_Lobry-P_Flandois-Comparison of Monod's Growth Model Parameters from the Same Data Set
    The paper obtains the parameters in Monod's Growth model using a minimization of the sum of square errors with a given data set and obtains confidence intervals

    Keywords: Confidence intervalssum of square errorslinearizationgrowthModo Growth model

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    Investigating the Drivers of Western Monarch Decline Using Partial Least Squares Regression
    In this lesson, students will explore the drivers of the western monarch butterfly decline. Students will compare the effects of climate factors and land use factors on the western monarch...

    Keywords: RStudiomultivariate analysisMonarch butterfliesPartial Least Squares Regression

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    A Direct Experience Study of Density-Dependent Growth
    An experiential approach to density-dependent growth using a checkerboard, 6-sided die, and two types of markers.

    Keywords: logistic growthdensity dependenceexperiential

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    3-015-StyrofoamBallFall-ModelingScenario
    We are given data on a falling Styrofoam ball and we seek to model this motion.

    Keywords: footballresistancegravityfalling bodysum of square errorsNewton's Second Law of Motionsum of forcesstyrofoam

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    Spreadsheet Data Analysis Tutorial Series
    This series of self-paced tutorials show how to analyze data using a spreadsheet program.

    Keywords: Resources @ HHMI - BioInteractiveScientific ProcessStatistics and MathScientific MethodologyHigh School

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    2010-Shianga-EtAl-Computational model of the human glucose-insulin regulatory system
    A computational model of insulin secretion and glucose metabolism for assisting the diagnosis of diabetes mellitus in clinical research is introduced. The

    Keywords: glucose tolerance testsum of squared residualsmultiple shooting methodcost function

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    3D breast cancer tissue reconstruction
    This module allows students to follow a researcher as she discovers new features of breast cancer tissue architecture, using 3D reconstructions of histological specimens.

    Keywords: graphingdata visualizationbreast cancerDCIShistogramscentroidsums of squares

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