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  1. Understanding the Importance of Microtubules in Normal Cell Division: Chemotherapy Connection

    10 Apr 2024 | Teaching Materials | Contributor(s):

    By Patricia Melloy*

    Fairleigh Dickinson University

    In introductory courses, students learn about microtubules as important structures but may not engage in a hands-on experience to localize microtubules themselves or to learn about their connection...

    https://qubeshub.org/publications/4663/?v=1

  2. 2016-Wilkie-EtAl-Using ODEs to Explore Cancer-Immune Dynamics and Tumor Dormancy

    09 Apr 2023 | Teaching Materials | Contributor(s):

    By Kathleen Wilkie

    NA

    Here we present a general method using ordinary differential equations (ODEs) to model and analyze cancer-immune interactions, and in particular, immune-induced tumor dormancy.

    https://qubeshub.org/publications/4172/?v=1

  3. 2015-Heiko_Enderling-Integrating experimental data to calibrate quantitative cancer models

    08 Apr 2023 | Teaching Materials | Contributor(s):

    By Heiko Enderling

    NA

    For quantitative cancer models to be meaningful and interpretable the number of unknown parameters must be kept minimal. We focus on a tumor hierarchy of cancer stem and progenitor non-stem cancer...

    https://qubeshub.org/publications/4137/?v=1

  4. 2014-Enderling-Chaplain-Mathematical Modeling of Tumor Growth and Treatment

    08 Apr 2023 | Teaching Materials | Contributor(s):

    By Heiko Enderling1, Mark Chaplain1

    NA

    Herein we describe fundamentals of mathematical modeling of tumor growth and tumor-host interactions, and summarize some of the seminal and most prominent approaches.

    https://qubeshub.org/publications/4109/?v=1

  5. 2012-Gilbert_Koch-Modeling of Pharmacokinetic and Pharmacodynamics of Cancer and Arthritis

    07 Apr 2023 | Teaching Materials | Contributor(s):

    By Gilbert Koch

    NA

    In this work we develop preclinical PKPD models based on fundamental biological and pharmacological principles. Equipped with a PKPD model, different dosing schedules could be simulated.

    https://qubeshub.org/publications/4077/?v=1

  6. 1999-Peter_Deuflhard-Differential Equations in Technology and Medicine

    26 Mar 2023 | Teaching Materials | Contributor(s):

    By Peter Deuflhard

    NA

    It deals with a variety of challenging real life problems selected from clinical cancer therapy, communication technology, polymer production, and pharmaceutical drug design.

    https://qubeshub.org/publications/3867/?v=1

  7. 2020-Stepien_Kostelich_Kuang-Mathematics Cancer An Undergraduate Bridge Course in Applied Mathematics

    07 Mar 2023 | Teaching Materials | Contributor(s):

    By Tracy L. Stepien1, Eric J. Kostelich1, Yang Kuang1

    NA

    Most undergraduates have limited experience with mathematical modeling. This paper describes a course on the mathematical models of cancer growth and treatment.

    https://qubeshub.org/publications/3730/?v=1

  8. Metastatic Mastery: A Case and Game-Based Approach to Learning About Cancer Mechanisms

    07 Aug 2022 | Teaching Materials | Contributor(s):

    By Sayali Kukday*1, Emilyn Frohn2, Alice Paige3

    1. Iowa State University 2. Biomedical Animator 3. Fiction Author and Essayist

    Mechanisms that contribute to the development of cancer are numerous and complicated, though most can be traced to a set of mutations in cell cycle regulatory genes that throw the process of cell...

    https://qubeshub.org/publications/3420/?v=1

  9. 1-102C-CancerGrowth-ModelingScenario

    22 May 2022 | Teaching Materials | Contributor(s):

    By Jennie D'Ambroise1, Jue Wang

    SUNY Old Westbury, Old Westbury NY USA

    This module guides students in the use of differential equation models to predict cancer growth and study treatment outcomes. Several classical models for cancer growth are presented including...

    https://qubeshub.org/publications/3222/?v=1

  10. 1-150-CancerTherapy-ModelingScenario

    22 May 2022 | Teaching Materials | Contributor(s):

    By Iordanka Panayotova1, Maila Hallare2

    1. Christopher Newport University 2. NSU Math

    This activity builds upon elementary models on population growth. In particular, we compare two different treatment models of cancer therapy where in one, surgery happens before therapy and in the...

    https://qubeshub.org/publications/3195/?v=1

  11. 6-017-OncolyticViruses-ModelingScenario

    06 May 2022 | Teaching Materials | Contributor(s):

    By Iordanka Panayotova1, Maila Brucal-Hallare2

    1. Christopher Newport University, Newport News VA 23606 USA 2. Norfolk State University, Norfolk VA 23504 USA

    Students explore oncolytic virotherapy using systems of differential equations and numerical simulations.

    https://qubeshub.org/publications/2997/?v=1

  12. Teaching Cancer Biology Through a Lens of Social Justice

    04 Nov 2021 | Teaching Materials | Contributor(s):

    By Yarid A. Mera1, Benjamin L. Wiggins*2

    1. Seattle University 2. University of Washington

    The biology classroom is not separate from the greater context of society; social issues can and should be presented in connection with the content. Here we present an example of antiracist...

    https://qubeshub.org/publications/2775/?v=1

  13. Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson

    24 Sep 2021 | Teaching Materials | Contributor(s):

    By Leigh Ann Samsa*1, Melissa Eslinger2, Adam Kleinschmit3, Amanda Solem4, Carlos C. Goller*1

    1. North Carolina State University 2. United States Military Academy 3. University of Dubuque 4. Hastings College

    There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has...

    https://qubeshub.org/publications/2753/?v=1

  14. GMC: Genes, Mutations and Cancer - Group Concept Map Development

    28 Aug 2021 | Teaching Materials | Contributor(s):

    By Shoshana D. Katzman*1, John H. Horne2, Sonu S. Baral3, Keith P. Choe4, Elizabeth Eich5

    1. Georgia Gwinnett College 2. University of New Orleans 3. Louisiana State University 4. University of Florida 5. Rice University

    It has been shown that active learning strategies used in the classroom can increase student learning and retention of information. We generated an active learning exercise that can be used in the...

    https://qubeshub.org/publications/2736/?v=1

  15. Building a Model of Tumorigenesis: A small group activity for a cancer biology/cell biology course

    22 Aug 2021 | Teaching Materials | Contributor(s):

    By Leslie Kate Wright

    Rochester Institute of Technology

    The multistep nature of tumorigenesis is a foundational concept in the context of Cancer Biology. Many students do not appreciate the complex nature of cancer development nor do they understand how...

    https://qubeshub.org/publications/2536/?v=1

  16. Why do Some People Inherit a Predisposition to Cancer? A small group activity on cancer genetics

    22 Aug 2021 | Teaching Materials | Contributor(s):

    By Michelle K. Smith1, Scott Merrill1

    University of Maine

    Before undergraduate students take a genetics course they generally know cancer has a genetic basis and involves the proliferation of cells; however, many are uncertain about why only a subset of...

    https://qubeshub.org/publications/2513/?v=1

  17. Bioimage Informatics Activity

    26 Jul 2018 | Teaching Materials | Contributor(s):

    By David Julian

    Univ of Florida

    Students use basic bioimage informatics techniques to acquire quantitative data from images of cultured cells and test a hypothesis about the effect of a genetic mutation on cellular phenotypes

    https://qubeshub.org/publications/729/?v=1

  18. Drug screening and cancer resistance: EGFR Activity

    25 Jul 2018 | Teaching Materials | Contributor(s):

    By Holly Basta

    Rock Mountain College

    This activity explores a specific gene (egfr) and its role in cancer. EGFR was introduced with the Gene Card Activities, researched throughout the semester, and then authentic image data of...

    https://qubeshub.org/publications/720/?v=1

  19. Geoscience Methods and Resources for K-5 Pre-Education Majors

    28 May 2018 | Teaching Materials | Contributor(s):

    By James Burton Deemy

    College of Coastal Georgia

    : Exploring Geoscience Methods was an excellent capstone experience for Elementary Education Majors. The class I used this module with was 24 students of various backgrounds and academic...

    https://qubeshub.org/publications/572/?v=1

  20. Calculating Lifetime Cancer Risk Resulting from DNA Replication

    18 Jan 2018 | Teaching Materials | Contributor(s):

    By Rebecca Orr1, Ruth Buskirk2, Kristin Harvey2

    1. Collin College 2. University of Texas at Austin

    An expanded case study adapted from an HHMI Data Point on Cell Division and Cancer Risk using Figure 1 from Tomasetti, C. and Vogelstein, B. (2015).

    https://qubeshub.org/publications/310/?v=1

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