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  1. Pharmacokinetics

    19 Aug 2024 | Teaching Materials | Contributor(s):

    By Gretchen A. Koch

    Goucher College

    This Excel module explores how drugs are processed and absorbed in the human body.

    https://qubeshub.org/publications/4957/?v=1

  2. 1-131-CaffeineElimination-ModelingScenario

    18 Jun 2024 | Teaching Materials | Contributor(s):

    By Beulah Agyemang-Barimah, Theresa Laurent, Therese Shelton

    We model the concentration of caffeine eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the...

    https://qubeshub.org/publications/3207/?v=2

  3. 1-132-DigoxinElimination-ModelingScenario

    13 Aug 2023 | Teaching Materials | Contributor(s):

    By Therese Shelton, Beulah Agyemang-Barimah1, Theresa Laurent2

    1. Cornell University, Ithaca NY USA 2. St. Louis College of Pharmacy, St. Louis MO USA

    We model the concentration of digoxin eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study...

    https://qubeshub.org/publications/3206/?v=2

  4. Sami Kanderian

    https://qubeshub.org/community/members/37186

  5. 2023-TechShareNotes. Differential Equations Modeling

    11 Apr 2023 | Teaching Materials | Contributor(s):

    By Tech Share Notes

    NA

    TechShareNotes is a web site with rich differential equation modeling html pages and this one is about mixing in one, two, and three tanks, with interesting questions and problems as well as...

    https://qubeshub.org/publications/4230/?v=1

  6. 2018-LA_Peletier-Ordinary Differential Equations in Pharmacodynamics

    11 Apr 2023 | Teaching Materials | Contributor(s):

    By L Peletier

    NA

    Good mix of theory, application, solution technique in a number of areas of applications of differential equations. Develops qualitative behavior issues. Exercises, but not about models, more about...

    https://qubeshub.org/publications/4227/?v=1

  7. 2018-David_Bourne-Pharmacokinetics – Source Material

    10 Apr 2023 | Teaching Materials | Contributor(s):

    By David Bourne

    NA

    This is a rich source of pharmacokinetics modeling activities and data. These are syllabus notes with homework assignments listed.

    https://qubeshub.org/publications/4219/?v=1

  8. 2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics

    10 Apr 2023 | Teaching Materials | Contributor(s):

    By American Society of Health- System Pharmacists

    NA

    This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.

    https://qubeshub.org/publications/4180/?v=1

  9. 2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics

    09 Apr 2023 | Teaching Materials | Contributor(s):

    By American Society of Health- System Pharmacists

    NA

    This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.

    https://qubeshub.org/publications/4181/?v=1

  10. 2015-Valerie_Billard-Pharmacokinetic-pharmacodynamic relationship of anesthetic drugs - from modeling to clinical use

    08 Apr 2023 | Teaching Materials | Contributor(s):

    By Valerie Billard

    NA

    The purpose of this short review is to describe the basis of pharmacokinetics and modeling, the concentration-effects relationship, and drug interactions modeling to offer to anesthesiologists and...

    https://qubeshub.org/publications/4152/?v=1

  11. 2004-Ledzewicz-Schattler-Application of Control Theory in Modelling Cancer Chemotherapy

    08 Apr 2023 | Teaching Materials | Contributor(s):

    By Urszula Ledzewicz1, Heinz Schattler1

    NA

    In this paper we discuss how to incorporate more realistic medical aspects of chemotherapy which hitherto have been neglected in the models.

    https://qubeshub.org/publications/3972/?v=1

  12. 2014-Wang-EtAl-Estimating Mixed-Effects Differential Equation Models

    08 Apr 2023 | Teaching Materials | Contributor(s):

    By L J Wang

    NA

    When multiple replicates of measurements are available for the dynamic process, it is of great interest to estimate mixed-effects in the ODE model for the process. We propose a semiparametric...

    https://qubeshub.org/publications/4120/?v=1

  13. 2012-Shargel-Yu-AccessPharmacy-Applied Biopharmaceutics and Pharmacokinetics

    07 Apr 2023 | Teaching Materials | Contributor(s):

    By Shargel Yu

    NA

    Step by step formation of drug absorption models is shown with many good graphics of system and plots. Solutions are offered but no solution methods are shown.

    https://qubeshub.org/publications/4088/?v=1

  14. 2011-GA_Koch-Noble-Drugs in the Classroom Using Pharmacokinetics to Introduce Biomathematical Modeling

    06 Apr 2023 | Teaching Materials | Contributor(s):

    By G. A Koch-Noble

    NA

    By beginning with simple model involving the half-life of a drug, students take advantage of their mathematical abilities to explore the biology.

    https://qubeshub.org/publications/4055/?v=1

  15. 2009-Su-EtAl-Fitting Compartmental Models to Multiple Dose Pharmacokinetic Data using SAS

    06 Apr 2023 | Teaching Materials | Contributor(s):

    By Jing Su

    NA

    In the case of a multiple dose study where subjects experience different dosing times, a superposition principle can be used to recursively account for each additional dose.

    https://qubeshub.org/publications/4038/?v=1

  16. 2006-Han-EtAl-Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology

    05 Apr 2023 | Teaching Materials | Contributor(s):

    By Jae-Joon Han

    NA

    Physiologically-based pharmacokinetic (PBPK) models have been used to describe the distribution and elimination characteristics of intravenous ethanol administration.

    https://qubeshub.org/publications/3986/?v=1

  17. 2005-Minna_Wedenberg-Pharmacokinetic modeling of gastric emptying

    04 Apr 2023 | Teaching Materials | Contributor(s):

    By Minna Wedenberg

    NA

    The development of new drug substances is a complex, time consuming and expensive process. Reducing the time for drug development and avoiding late termination of candidate drugs are important...

    https://qubeshub.org/publications/3977/?v=1

  18. 2004-Aldo_Rescigno-On the use of pharmacokinetic models

    04 Apr 2023 | Teaching Materials | Contributor(s):

    By Aldo Rescigno

    NA

    In this paper I will define in a simple and logical way a set of useful pharmacokinetic parameters and show how their estimation depends on the assumed model.

    https://qubeshub.org/publications/3967/?v=1

  19. 2000-Erdman-Morelock-A Study of Kinetics The Estimation and Simulation of Systems of First-Order Differential Equations

    02 Apr 2023 | Teaching Materials | Contributor(s):

    By Donald Erdman

    NA

    This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.

    https://qubeshub.org/publications/3943/?v=1

  20. 1999-Khorasheh-Ahmadi-Gerayeli-Application of Direct Search Optimization for Pharmacokinetic Parameter Estimation

    31 Mar 2023 | Teaching Materials | Contributor(s):

    By Farhad Khorasheh

    NA

    For simple pharmacokinetic compartmental models, analytical solution to the governing differential equations provide a mean to evaluate the associated rate constants. Such methods, however, can not...

    https://qubeshub.org/publications/3918/?v=1

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