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  • Created 28 Oct 2020

Selected Modules

A set of molecular case studies have been selected for discussion and implementation for this Faculty Mentoring Network (FMN) in the Spring 2021 semester. These cases cover a range of topics in biology, chemistry, biochemistry, genetics, botany etc. so please select the one that best fits your course curriculum. Brief descriptions of these cases are included below.

Participating faculty will first be introduced to these cases and all the tools/resources necessary to run the cases. This will ensure that faculty who are new to the disciplinary contents and skills/tools needed for molecular structure-function discussions have the opportunity to read, learn, and prepare. Following this, participants will have the choice to take one of two paths - a. adopt, adapt, and implement at least one of these six cases in their classrooms and provide feedback about this experience; or b. collaborate with others to develop a new case for the Molecular CaseNet on a topic/story that they are familiar with. 

Nicholas' Story

Shuchismita Dutta, Kimberly Linenberger Cortes, Henry Vincent Jakubowski, Melanie Lenahan, David Marcey, Pat Marsteller, Cassidy Terrell

Version: 1.0

This 3 part case on sickle cell disease focuses on visualizing and understanding the molecular basis of its cause, symptoms, complications, management, treatment, and possible cures.
Hemoglobin, molecular visualization and analysis, sickle cell disease, PDB, Molecular Case Study, Teaching material, Undergraduate
209
30
3
0
06.2020

Happy Blue Baby

Shuchismita Dutta

Version: 1.0

This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved on its own in a few months.
mutation, Hemoglobin, molecular visualization and analysis, PDB, Molecular Case Study, Teaching material, Undergraduate
142
34
1
0
06.2020

Waking up Anna

Kate K. O'Toole, Shuchismita Dutta

Version: 1.0

This case focuses on understanding the molecular basis of Anna's sleeping disorder and its treatment.
sleep, molecular visualization and analysis, PDB, Molecular Case Study, GABA, Teaching material, Undergraduate
202
29
0
0
06.2020

Piwi Matters

Laurel Lorenz, Shuchismita Dutta

Version: 1.0

This case focuses on understanding structure and function relationships in Piwi, a protein that is critical for germline stem cell function and development of eggs in the fruit fly ovary.
Stem cells, molecular visualization and analysis, 3D protein structure /function analysis, Piwi, PDB, Molecular Case Study, Teaching material, Undergraduate
167
34
1
0
06.2020

Evolution of Caffeine Biosynthesis Enzymes

Brian Sullivan, Shuchismita Dutta

Version: 1.0

This case focuses on exploring why plants make secondary metabolites like caffeine and how the enzymes required for making caffeine evolved.
Evolution, caffeine, molecular visualization and analysis, enzymes, PDB, Molecular Case Study, Teaching material, Undergraduate
155
31
0
0
06.2020

A Case of Severe Insulin Resistance

Melanie Lenahan, Shuchismita Dutta

Version: 1.0

This case focuses on understanding how a mutation in a cell signalling protein (a kinase) can prevent insulin function and lead to diabetes.
molecular visualization and analysis, PDB, Molecular Case Study, insulin resistance, Teaching material, Undergraduate
151
31
0
0
06.2020

COVID-19: Molecular Basis of Infection

Didem Vardar-Ulu, Shuchismita Dutta

Version: 1.0

This case was written in Spring 2020 during the COVID-19 pandemic. It focuses on understanding the structure and interaction of the SARS-Cov-2 viral spike protein that facilitates infection in human cells.
infection, vaccine, molecular visualization and analysis, COVID19, PDB, SARS-CoV, Molecular Case Study, Teaching material, Undergraduate
225
47
1
0
06.2020

Understanding COVID-19 Biology to Design a Vaccine

Keith Johnson, Didem Vardar-Ulu, Shuchismita Dutta

Version: 1.0

This multi-part case study introduces the reader to the SARS-CoV-2 virus, replication, and treatment. Additional worksheets introduce students to bioinformatics tools of 3-D protein visualization and BLAST searches.
BLAST, protein structure modeling, molecular visualization and analysis, COVID19, PDB, introductory, Lab, Online course, Teaching material, High School, Reference material, Undergraduate, Homework, Advanced, Majors, Extended Project
429
329
2
0
06.2020