Description

Tony Allison first noticed a connection between malaria and the sickle cell trait while working in East Africa in the 1950s. The story of his discovery stands as one of the best understood examples of natural selection in humans in which the selective agent, adaptive mutation, and molecule involved are all known. The protection against malaria provided by the sickle cell mutation demonstrates how evolution does not necessarily result in optimal solutions for the species but proceeds in response to selective pressures by utilizing what variation is available.

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