Resource Image

Cystic Fibrosis Mechanism and Treatment

Author(s): HHMI BioInteractive

658 total view(s), 99 download(s)

0 comment(s) (Post a comment)

Summary:
This animation shows how mutations in an ion channel protein lead to the genetic disease cystic fibrosis. The animation also discusses how research on this protein has been used to develop treatments for the disease.

Licensed under CC Attribution-NonCommercial-NoDerivatives 4.0 International according to these terms

Version 1.0 - published on 01 Jul 2019 doi:10.25334/3RFD-6T62 - cite this

Description

Cystic fibrosis is an autosomal recessive disease caused by mutations in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. CFTR is an ion channel protein that transports chloride ions across the membranes of cells that line airways, glands, and the digestive tract. This animation illustrates how cystic fibrosis mutations can prevent CFTR from functioning properly, leading to the production of a thick mucus that obstructs airways and promotes infections. After screening hundreds of thousands of small molecules, scientists have identified a drug that can improve CFTR function and treat the disease in some patients.

Depending on students’ background, it may be helpful to pause the animation at various points to discuss different structures or molecules.

Cite this work

Researchers should cite this work as follows:

Comments

There are no comments on this resource.