Research experiences provide a valuable view into the world of science and a great way to explore new fields and careers while developing critical thinking skills. The development and maintenance of databases have allowed researchers to accelerate research in many fields, and understanding how to use them opens doors to actual data for scientific purposes. This resource will give students the opportunity to use research tools with published data to answer questions about immunological topics. The activities in this lesson can be used in Biology, Biotechnology, Microbiology, Bioinformatics, and Introductory Immunology courses. In addition, this activity includes a Student Activity and Instructor Notes with solutions and extra guidance for educators.