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Regulation of Malate Dehydrogenase by Fumarate

Author(s): Victoria Lange

University of San Diego

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A "snippet" paper

Licensed under CC Attribution-ShareAlike 4.0 International according to these terms

Version 1.0 - published on 27 Oct 2023 doi:10.25334/625V-EX92 - cite this

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Description

Malate Dehydrogenase (MDH) synthesizes oxaloacetate from malate, allowing a new
round of the citric acid cycle to begin. This cycle provides necessary components for the rest of
cellular respiration, therefore understanding the regulation of the cycle and each individual
enzyme is extremely important for understanding metabolism. Fumarate, used in the previous
step of the cycle, has yet to be explored as a potential regulatory element for MDH. Here, we
run rate-determining absorbance tests at varying concentrations of fumarate, and ultimately
find that the ligand is inhibitory to mitochondrial MDH.

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