Regulation of Malate Dehydrogenase by Fumarate
Author(s): Victoria Lange
University of San Diego
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Summary:
A "snippet" paper
Contents:
eb-Lange-Inhibition Snippet - Oct 23-v 2.pdfDescription
Malate Dehydrogenase (MDH) synthesizes oxaloacetate from malate, allowing a new
round of the citric acid cycle to begin. This cycle provides necessary components for the rest of
cellular respiration, therefore understanding the regulation of the cycle and each individual
enzyme is extremely important for understanding metabolism. Fumarate, used in the previous
step of the cycle, has yet to be explored as a potential regulatory element for MDH. Here, we
run rate-determining absorbance tests at varying concentrations of fumarate, and ultimately
find that the ligand is inhibitory to mitochondrial MDH.
Cite this work
Researchers should cite this work as follows:
- Lange, V. (2023). Regulation of Malate Dehydrogenase by Fumarate. Journal of CURE Research, QUBES Educational Resources. doi:10.25334/625V-EX92