Scientific leadership and current artificial intelligence (AI) skills are important skills to be included in the course curriculum. Together or individually, these skills can enhance knowledge, critical thinking, and creativity. In this guide, we provide an overview of how leadership skills and AI can be integrated into class activities to help students understand examples of regulating gene expression. Through the activities, students develop an understanding that genomics is an interdisciplinary, transdisciplinary and multidisciplinary field to study gene structure. Using simulations, students use the prokaryotic lac operon and eukaryotic lactase gene to learn about regulatory processes of transcription and translation. By studying the lac operon in bacteria and the lactase gene in eukaryotes, students can apply these concepts by performing independent literature searches to additional mechanisms of gene regulation. This lesson highlights the nature of central dogma of molecular biology and also provides introduction of key concepts in genomics.