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    Bioinformatics / Neuroinformatics
    This module is a computer-based introduction to bioinformatics resources.  This easy-to-adopt module weaves together several important bioinformatic tools so students can grasp how each is used in...

    Keywords: bioinformaticsNIBLSEImageJquantitative trait locusQTL

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    Hardy-Weinberg Equilibrium: a swirl resource
    Students will use swirl to understand Hardy-Weinberg equilibrium. The lesson starts with observed numbers of individuals for each genotype, and students will work through a number of steps to...

    Keywords: Hardy-Weinbergpopulation geneticsEvolutionevolutionary ecologyR programming languageSwirl

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    Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes
    Students require a deep understanding of the central dogma before they can understand complex topics such as evolution and biochemical disorders. However, getting undergraduate biology students to...

    Keywords: Protein Structurecomputational modelingcentral dogmaplant leaf structurePhenotype/Genotype

    1995

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    527

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    Operon
    This Excel workbook models lac operon function in a partial diploid E. coli. The user chooses the bacterial genotype and the sugars present in the surrounding medium: the workbook then determines...

    Keywords: Lac OperonE. coli

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    Honoring the Complexity of Genetics: Exploring the Role of Genes and the Environment Using Real World Examples
    Historically, undergraduate genetics courses have disproportionately focused on the impact of genes on phenotypes, rather than multifactorial concepts which consider how a combination of genes, the...

    Keywords: genesenvironmentMendelQuantitative traitsMultifactorialGene by environment interactions

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    Garden Variety Mutations: Using Primary Data to Understand the Central Dogma in Large-Lecture Introductory Biology
    The ability to interpret and create an argument from data is a crucial skill for budding scientists, yet one that is seldom practiced in introductory courses. During this argumentation module,...

    Keywords: mutationtranscriptiongene expressioncentral dogmatranslationgel electrophoresisGenotype/Phenotype

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    A Rapid Genetic Screen Using Wisconsin Fast Plants®: A Hands-On Approach to Inheritance of de novo Mutations
    Some concepts in genetics, such as genetic screens, are complex for students to visualize in a classroom and can be cumbersome to undertake in the laboratory. Typically, very large populations are...

    Keywords: mutationInheritancegermlinesomaplant lifecycle

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    ABO Blood Group Frequencies
    An Excel workbook in which students can calculate blood type frequencies through different approaches (Hardy-Weinberg, quadratic formula, and the EM algorithm). The workbook shows the formulas...

    Keywords: Hardy-Weinbergblood type frequencies

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    Why do Some People Inherit a Predisposition to Cancer? A small group activity on cancer genetics
    Before undergraduate students take a genetics course they generally know cancer has a genetic basis and involves the proliferation of cells; however, many are uncertain about why only a subset of...

    Keywords: cancerInheritance patternsProbability calculationProto-oncogeneTumor Suppressor Gene

    1793

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    449

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    Web Popgen
    A Hardy-Weinberg simulation program.

    Keywords: Hardy-Weinbergpopulation geneticscomputer simulationsGenetic DriftmutationNatural Selection

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    Module 6: Alternative Splicing
    This module explores how multiple different mRNAs and polypeptides can be encoded by the same gene. After completing this module students will be able to explain how alternative splicing of a gene...

    Keywords: geneticsdata visualizationmolecular biologygenomicsexonintronalternative splicingSimilarity searchesMessenger RNA

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    What the Mendel
    Students practice hypothesis testing using Mendelian genetics for monohybrid and dihybrid crosses. Both corn and Wisconsin Fast Plants are employed.

    Keywords: geneticsplantsmendelian inheritancephenotypecotelydoncornWisconsin fast plants

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    544

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    Allele and Phenotype Frequencies in Rock Pocket Mouse Populations
    A lesson that uses real rock pocket mouse data collected by Dr. Michael Nachman and his colleagues to illustrate the Hardy-Weinberg principle.

    Keywords: EvolutionResources @ HHMI - BioInteractiveNatural SelectionScientific ProcessStatistics and Mathevolution of populations

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    478

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    Behavioral Genetics: Investigating the genes of a complex phenotype in fruit flies
    Introductory genetics laboratory published as GSA Learning Resource

    Keywords: behaviorbioinformaticsNIBLSEdrosophilagenetic basisfruit fliesmodel organism

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    T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection
    Article presenting evidence that the bitter taste receptor T2R38 regulates the mucosal innate defense of the human upper airway.
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    Workshop Report: Summer 2020 Virtual CRISPR in the Classroom
    As innovations and developments in genome editing technologies using CRISPR-Cas systems progress, the need to disseminate relevant knowledge and build skills among the next generation of young...

    Keywords: geneticscrisprGenome Analysisgene editingbacterial immunity

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    Splicing it Together: Using Primary Data to Explore RNA Splicing and Gene Expression in Large-Lecture Introductory Biology
    At the heart of scientific ways of knowing is the systematic collection and analysis of data, which is then used to propose an explanation of how the world works. In this two-day module, students...

    Keywords: gene regulationtranscriptiongene expressioncentral dogmarepressoralternative splicingmRNA processingActivatorTranscription factors

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    CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students
    Providing undergraduate life-science students with a course-based research experience that utilizes cutting-edge technology, is tractable for students, and is manageable as an instructor is a...

    Keywords: bioinformaticsPCRphenotypingCRISPR/Cas9gene editingcloningGenotypingRestriction enzyme

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    A Structured Inquiry Approach to Cotyledon Phenotyping
    In this lab, students will work with messy data to try to answer the question “How do plants inherit cotyledon color?”

    Keywords: geneticsplantsphenotypecotelydon

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    Birthday Problem and Class Phenotypic Probabilities
    An Excel workbook exploring two related applications, the Birthday Problem and Class Phenotypic Probabilities. Students enter their own phenotypes into the workbook.

    Keywords: phenotypic probabilityallelic frequency

    1148

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    233

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