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    Sanger Sequencing by Hand: Using Paper Clips to Demonstrate Chain Termination
    Sanger sequencing is commonly taught with a hands-on approach. Sanger sequencing involves chain termination by dideoxynucleotides, because they are missing the oxygen on the 3’ carbon atom,...

    Keywords: nucleotidessequencingDNAgel electrophoresisChain Termination

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    Modeling Strep Throat Detection, Infection, and Spread Using an SIR Model and the Vensim Simulation Software
    The overarching goal of this lesson is to provide students with an opportunity to gain experience making and using biological models. Biological modeling can be used to investigate complex,...

    Keywords: infectious diseasebiological modelingSIR model

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    2011-Yanyu_Xiao-Study of Malaria Transmission Dynamics by Mathematical Models
    The novelty lies in the fact that different distribution functions are used to describe the variance of individual latencies. The theoretical results of this project indicate that latencies reduce...

    Keywords: infectious diseaseinfectionmalarialatencyspatial dispersalmulti-species

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    2012-Tweedle-Smith-Mathematical model of Bieber Fever-The most infectious disease of our time
    We develop a mathematical model to describe the spread of Bieber Fever, whereby individuals can be susceptible, Bieber-infected or bored of Bieber.

    Keywords: infectious diseasediseaseinfectionmediaJustin BieberBieber feversymptomsboredreproductive ratio

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    2011-Lorelei_Koss-Sustainability_in_a_differential_equations_course_case_study_of_Easter_Island
    Easter Island is a fascinating example of resource depletion and population collapse, and its relatively short period of human habitation combined with its isolation lends itself well to...

    Keywords: differential equationssustainabilitypopulationEaster Islandcollapseenvironmental collapse

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    2002-Dietz-Heesterbeek-Daniel Bernoulli-epidemiological model revisited
    The seminal paper by Daniel Bernoulli published in 1766 is put into a new perspective. After a short account of smallpox inoculation and of Bernoulli’s life, the motivation for that paper and its...

    Keywords: life tableepidemicsmallpoxDaniel Bernoullicompeting riskinoculation

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    Obesity - An Epidemic with Unexpected Causes, Consequences, and Complexity
    This dataset was collected from interviews conducted by the Centers for Disease Control and Prevention. State by state data are provided to explore the interactions of education, income, and...

    Keywords: ObesitySocioeconomic StatusFood SwampFood Desert

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    Understanding COVID-19 Biology to Design a Vaccine
    This multi-part case study introduces the reader to the SARS-CoV-2 virus, replication, and treatment. Additional worksheets introduce students to bioinformatics tools of 3-D protein visualization...

    Keywords: BLASTprotein structure modelingmolecular visualization and analysisCOVID19PDB

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    Morphological identification of mosquitoes through microscopic observation
    Scientific research is integrated into various stages of student learning, but hands-on involvement in the research process typically begins at the university level. This module aims to engage high...

    Keywords: modulebiologyproject based learningmosquitoScientific researchMicroscope usedigital accessibility

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    Happy Blue Baby
    This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved on its own...

    Keywords: mutationHemoglobinmolecular visualization and analysisgenetic basisPDBMolecular Case StudyMol*

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    1-102-CancerTumor-ModelingScenario
    This module guides students in the use of differential equation models to predict cancer growth and optimize treatment outcomes. Several classical models for cancer growth are studied, including ...

    Keywords: optimizationlogisticpredictiondata fittingpower lawGompertzcancer growtheponentialBertalanaffy

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    1-102C-CancerGrowth-ModelingScenario
    This module guides students in the use of differential equation models to predict cancer growth and study treatment outcomes. Several classical models for cancer growth are presented including...

    Keywords: optimizationcancerlogisticexponentialpredictiontumorgrowthdata fittingpower lawBertanffyGompertz

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    2017-Bonin-EtAl-Mathematical modeling based on ordinary differential equations - promising approach to vaccinology
    As a proof of concept, we developed a model of the immune response to vaccination against the yellow fever. Our simulations have shown consistent results when compared with experimental data...

    Keywords: immune systemyellow fevercomputational immunologycomputational vaccinology

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    Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson
    There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has...

    Keywords: bioinformaticscancertranscriptomicshigh-throughputData wranglingSingle cell RNA sequencingq

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    2018-Arden_Baxter-Modeling Public Opinion
    In this paper, we adapt the epidemiological models to model the dynamics of public opinion. Public opinion is any view prevalent among the general public. Our model considers any topic or issue in...

    Keywords: epidemiologypopulationpublic opinion

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    2016-Bonin-EtAl-Mathematical modeling based on ordinary differential equations-vaccinology
    We developed a model of the immune response to vaccination against the yellow fever. Our simulations have shown consistent results when compared with experimental data available in the literature.

    Keywords: Immunologyimmune systemAntigenvaccinologyyellow fever

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    2020-Chen_Et_Al-MathModel_Simulation_Phase-Based_Transmissability_Corona_Virus
    In this study, we developed a Bats-Hosts-Reservoir-People transmission network model for simulating the potential transmission from the infection source (probably be bats) to the human infection.

    Keywords: basic reproduction numbercoronavirusnext generation matrixtransmissibilitynovel coronavirus

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    2000-deOlivera-Delfino-Costa-Leite-Pinhole Water Flow From Cylindrical Bottles
    The water flowing from the first bottle feeds the second one located below it. The same concepts of mass and energy conservation now lead to a non-trivial differential equation for the lowest...

    Keywords: Torricelli's LawConservation of EnergytConservation of MassBernoulli’s Theorem

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    Diseasebots
    This module explores the effects of host density on contact rates and transmission of pathogens or mutualist symbionts using a hands-on simulation, a computer agent-based model in NetLogo, and an...

    Keywords: NetLogoDisease ecologydensity dependenceSpreadsheethost-parasitemutualismOpen-inquiry group projectsmanipulative models (‘beanbag biology’)plotting

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    6-003-SchoolFluEpidemic-ModelingScenario
    We offer a model of the spread of flu in a school dormitory and are asked to find when the flu levels reach their peak and explain long term behavior of the spread of the flu.

    Keywords: infectionepidemicSIR modelflupeakschool children

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