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    Introduction to nucleotide sequence analysis and protein modeling in MEGA and PyMol using coronavirus SARS-CoV-2
    Introduction into computational approaches in phylogeny and protein modeling based on coronavirus SARS-CoV-2 (caused COVID-19 pandemic). Two self-guided tutorials for standard lab classes of 2.5...

    Keywords: phylogeneticsundergraduate educationbioinformaticsNCBICOVID19coronavirusMEGAPyMolvirtual labPDBprotein modelingSARSSARS-CoV

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    Ethics of Metabolic engineering
    This is an ethical reflection for students on an issue in metabolic engineering and the potential for "home-brew" morphine. The case study asks students to reflect on material in the linked...

    Keywords: biostatisticsstatistical analysisavian malariaSummer Workshop 2018

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    Ethics in synthetic genomics
    This is an ethical reflection for students on an issue in genome engineering and the synthesis of potentially infectious viruses. The case study asks students to reflect on material in the linked...

    Keywords: biostatisticsstatistical analysisavian malariaSummer Workshop 2018

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    Ethics of Gene Editing
    This is an ethical reflection for students on an issue in gene editing. The case study asks students to reflect on material in the two linked articles. Also included is the grading rubric.

    Keywords: biostatisticsstatistical analysisavian malariaSummer Workshop 2018

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    Drug screening and cancer resistance: EGFR Activity
    This activity explores a specific gene (egfr) and its role in cancer. EGFR was introduced with the Gene Card Activities, researched throughout the semester, and then authentic image data of...

    Keywords: Resources @ HHMI - BioInteractivegenomicscancergenetic basis of diseasebiology of cells

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    Tackling "Big Data" with Biology Undergrads: A Simple RNA-seq Data Analysis Tutorial Using Galaxy
    Analyzing high-throughput DNA sequence data is a fundamental skill in modern biology. However, real and perceived barriers such as massive file sizes, substantial computational requirements, and...

    Keywords: bioinformaticsDNA sequenceRNAseqgene expression

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    Investigating Cell Signaling with Gene Expression Datasets
    Modern molecular biology is a data- and computationally-intensive field with few instructional resources for introducing undergraduate students to the requisite skills and techniques for analyzing...

    Keywords: genomicstranscriptionsignaling

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    Effect of the Intestinal Protein Snakeskin on the Lifespan of Fruit Flies: A Kaplan-Meier Survival Analysissource Draft (1)
    In this activity, students perform the Kaplan-Meier survival analysis on raw data obtained from an experiment that explores the effect of overexpressing the Snakeskin (Ssk) protein on the lifespan...

    Keywords: graphingBiochemistryhypothesis testingcalculus and biologyapproximating areas under curvesqbccCellular and Molecular BiologyCreate graphsInterpret graphsSolving Equations and Inequalitiesinterpret tablesConcepts in Statisticsusing statisticschi-square analysissurvival analysis

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    Teaching the Central Dogma Using a Case Study of Genetic Variation in Cystic Fibrosis
    The central dogma of biology is a foundational concept that is traditionally included in genetics curricula at all academic levels. Despite its ubiquitous presence throughout genetics education,...

    Keywords: transcriptioncentral dogmatranslationsequence analysisDNA replicationgenetic variants

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    Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes
    Students require a deep understanding of the central dogma before they can understand complex topics such as evolution and biochemical disorders. However, getting undergraduate biology students to...

    Keywords: Protein Structurecomputational modelingcentral dogmaplant leaf structurePhenotype/Genotype

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    MCC - A National Malate Dehydrogenase Protein-Centric Molecular Life Sciences Couse-based Undergraduate Research Network (RCN-UBE Introduction)
    The MCC is an inclusive national community consisting of faculty, from community colleges, MSI, PUI and Research Intensive institutions teaching and developing Course based Undergraduate Research...

    Keywords: RCN-UBE Introduction

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    2016-Erno_Keszei-Chemical Kinetics for Beginners
    The most important goal of kinetic research is the identification and characterisation of elementary molecular events which make possible the transformation of reactants into products.

    Keywords: kineticszeroth order reactionfirst order reactionsecond order reactionreaction ratesthird order reaction

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    What is a species? Using DNA barcodes to identify species and determine insect responses to global warming
    Combining ecology, molecular tools and physiology, students investigate insect adaptation to temperatures along tropical mountains. Students integrate species concepts, DNA barcoding and thermal...

    Keywords: global warmingbeetleBiological species conceptCephaloleiacrticial thermal maximumcryptic specieselevational gradientsthermal limitstropical insectsZingiberales

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    Using Raw Sequence Data to Analyze Tumor Suppressor Mutations
    Learning to identify DNA sequence variants from raw sequencing data (electropherograms) is a basic molecular biology skill with applications to basic research and clinical practice. Yet learning to...

    Keywords: bioinformaticsmutationDNAgenomic visualizationparts of a geneclinical consequencesraw data

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    6-070-BeerBubbles-ModelingScenario
    The goal of this project is to set up and numerically solve a first-order nonlinear ordinary differential equation (ODE) system of three equations in three unknowns that models beer bubbles that...

    Keywords: molecular forensicsBEERspherebubbleNewton' Second LawIdeal Gas Lawdrag forceHadamardStokesmole

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    The Case of the Missing Strawberries: RFLP analysis
    While solving the fictional mystery of the missing strawberries, students are engaged in a guided-inquiry lesson featuring small-group and class discussions, hands-on activities, and laboratory...

    Keywords: process of scienceDNAforensicsgel electrophoresisMolecular genotypingRestriction endonucleaseRestriction enzymeRestriction fragment length polymorphismRFLP

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    Isolation and Functional Analysis of a Pancreatic Enzyme in an Introductory Student Lab
    Structure and function are correlated at all levels of biology. This topic is typically addressed early in an undergraduate class in general or molecular biology before students have gained much...

    Keywords: Protein StructureproteaseEnzymechemical bondscatalysissolubility

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    Analysis of Microbiomes Using Free Web-Based Tools in Online and In-Person Undergraduate Science Courses
    Our understanding of microbiomes, or the collection of microorganisms and their genes in a given environment, has been revolutionized by technological and computational advances. However, many...

    Keywords: microbiomeDNA SubwayCyVerseCourse based undergraduate researchQIIME2ranacapa

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    Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson
    There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has...

    Keywords: bioinformaticscancertranscriptomicshigh-throughputData wranglingSingle cell RNA sequencingq

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    Fragile States: A Case Study Exploring Genetics, Molecular Biology, and Biochemistry Through the Lens of Fragile X Syndrome
    This case aims to strengthen students’ understanding of molecular biology concepts through study of Fragile X Syndrome (FXS). Students begin by learning the cause and phenotypes of FXS and...

    Keywords: gene regulationtranscriptiontranslationFragile X syndrometriplet repeat expansionsex linkagemetabolic pathway

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