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    1987-Claude-Marmasse-Studies on differential equations of enzyme kinetics-Biomolecular scheme
    The integral curve is compared with the solutions given by the two classical approximations to the problem: it is shown that the steady-state approximation is to be preferred to the rapid...

    Keywords: steady-state modelisoclinesenzyme kinetics

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    1-034-T-FishMixing-ModelingScenario
    This activity gives students a chance to build the underlying differential equation and/or difference equation for a mixing problem using tangible objects (fish) and a student-designed restocking...

    Keywords: simulationfishFishingmixingrestocking

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    1-021-FeralCatControl-ModelingScenario
    Students act as professional mathematical consultants and write a report analyzing the client's problem. The client company is a fictional organization which advocates for the use of...

    Keywords: population growthcontrolferal catspopulation controlneutertrap-killtrap-neuter-return

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    1-138-InnerEarDrugDelivery-ModelingScenario
    Students examine local drug delivery to the cochlea. The delivery system is modeled as a liquid mixing problem. Students formulate the differential equation, and solve the equation using separation...

    Keywords: concentrationdrug deliveryinner earcochleahearing loss

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    3-026-SpringInverseProblem-ModelingScenario
    We are given data on the position of a mass in an oscillating spring mass system and we seek to discover approaches to estimating an unknown parameter.

    Keywords: datamassinverse problemspring\parameter estimate

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    1-016-DogDrugs-ModelingScenario
    We offer a problem to determine the necessary drug administration in order to keep a dog sedated with specific information on half-life for an exponentially decaying presence of the drug in the body.

    Keywords: wild_dogsdrug discoveryhalf-lifepentobarbital sodiumanesthesia

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    Mystery box puzzle for model based reasoning
    This is a computer based problem solving activity that I use to engage introductory biology students with discussions about model based reasoning.

    Keywords: Model Based ReasoningScientific reasoningpuzzle

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    21st Century STEM Workforce Skills
    This activity includes a leadership assessment and associated exercise to encourage the development of 21st Century STEM Skills.

    Keywords: collaborationteam scienceleadership skills

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    Search for the Missing Sea Otters
    National Center for Case Study Teaching in Science- using a progressive disclosure format, this case study teaches students how to apply ecological principles to a real-life ecological problem.

    Keywords: Community Ecologypopulation ecologypredationAlaskaSea otterkiller whaleOrcinus orcamarine mammalkelp bedpredatorecological energetics

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    Exploring HIV Evolution
    In this activity you will study aspects of sequence evolution by working with a set of HIV sequence data from 15 different subjects (Markham, et al., 1998). You will first learn about the dataset,...

    Keywords: EvolutionbioinformaticssequencingUndergraduateNIBLSEincubatorsHIVAudience LevelC1. Role of bioinformaticsC4. Bioinformatics toolsRecommended by NIBLSE

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    Cutthroat trout in Colorado: A case study connecting evolution and conservation
    Evaluation of evidence is a key process skill for the core competencies of applying the process of science and using quantitative reasoning. This case study enables upper-division biology students...

    Keywords: population geneticsphylogeneticsSpeciationdivergencegene flow

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    Integrating Community Ecology Into the Study of Parasites: Exploring the Effect of Host Behavior on Parasite Transmission Rates
    Organismal life cycles are often presented as a set of facts to memorize in undergraduate biology courses. This approach is cognitively demanding for students and fails to convey how central life...

    Keywords: statisticsspecies interactionsQuantitative reasoninggraphsCommunity EcologyParasitologyfood webs

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    Quantifying Uncertainty and Distinguishing Data Sets in Introductory Physics
    Physics labs are moving increasingly to open-ended experiments where students develop experimental physics skills, rather than verify textbook physics concepts. This sequence of activities sets the...

    Keywords: statisticsMeasurementlaboratoryuncertaintypendulumexperimental skills

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    2011-Teleken-EtAl-Mathematical modeling of microbial growth in milk
    A mathematical model to predict microbial growth in milk was developed and analyzed. The model consists of a system of two differential equations of first order. The equations are based on physical...

    Keywords: bacteriadairymilkfood safetymicrobilogy

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    Using Images of Foraging Leaf-Cutter Ants to Teach Linear Regression
    This lesson offers students a realistic, open-inquiry research experience, even when lab or field research is not possible. We first introduce students to leaf-cutter ants and how they forage. Then...

    Keywords: linear regressionexperimental designPlant-insect interactionsSymbiosisForaging behavior

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    The Biology of Climate Change: The effects of a changing climate on migrating and over-wintering species at a high-elevation field station
    Students evaluate weather and phenology data sets spanning 40+ years from a high-elevation field station in the Colorado Rocky Mountains, to test predictions about the effects of climate change on...

    Keywords: species interactionsclimate changefmnphenologyDIGenvironmental variationtrophic mismatch

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    Breaking It Down: What Factors Control Microbial Decomposition Rates?
    Demonstrating and modeling changes in ecosystem processes in the laboratory classroom can be logistically difficult and expensive. This complexity often leaves little time for students to generate...

    Keywords: data analysishypothesis testingdata visualizationdata managementMicrobial RespirationDecompostionAbiotic ConditionsResults Communication

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    Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson
    There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has...

    Keywords: bioinformaticscancertranscriptomicshigh-throughputData wranglingSingle cell RNA sequencingq

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    2012-Transtrum-Qiu-Optimal experiment selection for parameter estimation in biological differential equation models
    We explore the question to what extent parameters can be efficiently estimated by appropriate experimental selection.

    Keywords: experimental designsystems biologyAssociation & Data Fittingreaction ratesdecay rates

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    2012-Nokkaew-EtAl-Estimation of Algae Growth Model Parameters by a Double Layer Genetic Algorithm
    This paper presents a double layer genetic algorithm (DLGA) to improve performance of the information-constrained parameter estimations.

    Keywords: optimizationalgae growthgenetic algorithmssimulated dataconvergence of parameters

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