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The QUBES platform hosts hundreds of teaching materials, reference materials, and cloud-based software free to use and adapt using open Creative Commons licenses.

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    Translating Co-Translational Translocation
    Understanding the process of proteins targeting to specific locations within a cell is a fundamental part of cell biology. Synthesis of proteins by co-translational translocation, which also...

    Keywords: Topologyco-translational translocationendoplasmic reticulumprotease protection assaysecretory proteinssignal sequencetransmembrane proteins

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    MTT Assay Video Protocol
    This assay works great. However, the cells are killed during the course of the assay. If you want cells to remain alive use the Alamar Blue assay.

    Keywords: MTT Assay

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    Protein Import Into the ER: Understanding Experimental Methods for Old and New Cellular Discoveries
    Process Oriented Guided Inquiry Learning (POGIL) is an effective approach for group work in STEM courses. POGIL-style lessons foster active learning because they require students to communicate and...

    Keywords: Necessary and sufficientsignal sequenceProtein SynthesistrafficER importTranslocation

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    Scratch Assay (Cell Migration) Cell Block
    A video tutorial and pedagogy notes describing how to measure cell migration using a wound/scratch assay. This is an inexpensive and relatively easy experiment. A micropublication that used this...

    Keywords: wound healingcourse-based research experiences (CUREs)Cell culture-based researchScratch AssayCell migrationCancer cell biology

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    Drugging SARS-CoV-2
    This case study leads students through the process of proposing a drug for a novel protein. The Mpro protease of SARS-CoV-2 is explored in detail within the PDB. Aligns with first semester...

    Keywords: viruscoronavirusPDBSARS-CoV-2proteasedrug design

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    Setting up PC12 Differentiation Assay Cell Block
    How to conduct a differentiation assay using PC12 cells. Complete video protocol.

    Keywords: neurobiologycourse-based research experiences (CUREs)neuorscienceCell culture-based researchPC12

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    Migration Assay Protocol
    Migration is a key property of live cells and critical for normal development, immune response, and disease processes such as cancer metastasis and inflammation.

    Keywords: migration assay

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    A 360˚ View of COVID-19
    In March 2020, institutions underwent a massive transition to distance learning as a result of the COVID-19 pandemic. With so little time to devise new materials to maximize learning in the new...

    Keywords: geneticsImmunologyBiochemistrybioinformaticsmolecular evolutionpublic healthvirusCOVID19

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    Isolation and Functional Analysis of a Pancreatic Enzyme in an Introductory Student Lab
    Structure and function are correlated at all levels of biology. This topic is typically addressed early in an undergraduate class in general or molecular biology before students have gained much...

    Keywords: Protein StructureproteaseEnzymechemical bondscatalysissolubility

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    The Ames Test
    Introduction to the Ames Test, published as GSA Learning Resource

    Keywords: geneticsNIBLSEDNAames testassay

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    It's a Substrate... It's a Protein...No - It's an Enzyme! Teaching Using 3D Serine Protease Physical Modeling Activities to Confront Misconceptions.
    Reported misconceptions of enzyme-substrate interactions highlight the necessity for better, targeted instructional tools and assessments. A series of active learning activities with corresponding...

    Keywords: Protein StructureEnzymes-Substrate InteractionsNoncovalent InteractionsGeometric ComplementaryElectronicsStereochemistrySerine Proteases

    3051

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    Investigating human impacts on stream ecology: locally and nationally
    TIEE Module- How does nutrient pollution impact stream ecosystems locally and nationally?
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    Adaptation of Investigating human impacts on stream ecology: locally and nationally
    TIEE Module- How does nutrient pollution impact stream ecosystems locally and nationally?
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    An Interactive Protocol for In-Classroom DNA Extraction
    Using commonly available materials, this tool allows students to extract DNA, exploring DNA chemistry and the principles of experimental design and execution. We take a “Choose Your Own...

    Keywords: geneticsDNAbiochemical structure and function

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    Investigating human impacts on stream ecology: locally and nationally
    TIEE Module- How does nutrient pollution impact stream ecosystems locally and nationally? This is an adaptation of the module that includes statistical testing and links sections to a lab report...
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    Developing a semester long cancer cell culture CURE
    A weekly outline for developing a semester-long cell culture CURE. Includes examples of student class presentations with annotated notes.

    Keywords: cell biologyPresentationcourse-based research experiences (CUREs)Cell culture-based researchCBECSemester outline

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    Sickle Cell Disease and Natural Selection in Humans
    A short film explores the evolutionary connection between an infectious disease, malaria, and a genetic condition, sickle cell anemia. The animation explores the genetic causes and biological...

    Keywords: HHMI BioInteractive

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    The Biology of Skin Color
    This film explores the hypothesis that different tones of skin color in humans arose as adaptations to the intensity of ultraviolet radiation in different parts of the world.

    Keywords: Resources @ HHMI - BioInteractivegene regulationgene expressionAnatomy & Physiologyhuman evolutionfilm

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    Investigating human impacts on stream ecology: locally and nationally
    How does nutrient pollution impact stream ecosystems locally and nationally?
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    Globally endangered sea turtles of the Palmyra Atoll National Wildlife Refuge: A Focus on Scientific Analysis
    in this exercise students will make suggestions for designing a comprehensive research program, use survey data, critically analyze results, and devise methods for study.

    Keywords: case study

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