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    The p53 Gene and Cancer
    This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer.

    Keywords: Resources @ HHMI - BioInteractiveBiochemistrymolecular biologymacromoleculesGenetic disease

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    Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson
    There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has...

    Keywords: bioinformaticscancertranscriptomicshigh-throughputData wranglingSingle cell RNA sequencingq

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    Exploring Microbial Diversity: An Interactive In-Class Assignment for Biology and Microbiology Courses
    This interactive assignment engages students in a hands-on exploration of microbial diversity and the importance of microbes in ecosystems. Designed for General Biology II and Introduction to...

    Keywords: Microbiology EducationMicrobial DiversitymicrobiologyEcological Society of Americaecology educationresearch-based classroom instruction4DEE Framework

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    Why are Cells Small? Surface Area to Volume Ratio
    This module explores surface area to volume ratios in a cube and sphere in relation to cell size.

    Keywords: introductory biologygraphingRatiosOpenStaxqbccmanipulate equationsCellular and Molecular BiologyUse elementary functionsCreate graphsInterpret graphsRates and ProportionsSolving Equations and Inequalitiesinterpret tables

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    Natural Selection and Galápagos Finches
    A worksheet and accompanying data set that guides students through making and interpreting frequency distributions, selection differentials, and fitness functions.

    Keywords: EvolutionResources @ HHMI - BioInteractive

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    Module M.5 Linear mixed-effects models
    Introduction to Primate Data Exploration and Linear Modeling with R was created with the goal of providing training to undergraduate biology students on data management and statistical analysis...

    Keywords: R programming languageprimatespopulation ecology

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    Module M.8 Survival analysis
    Introduction to Primate Data Exploration and Linear Modeling with R was created with the goal of providing training to undergraduate biology students on data management and statistical analysis...

    Keywords: R programming languageprimatespopulation ecology

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    Module M.6 Generalized linear models
    Introduction to Primate Data Exploration and Linear Modeling with R was created with the goal of providing training to undergraduate biology students on data management and statistical analysis...

    Keywords: R programming languageprimatespopulation ecology

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    Module M.4 Simple linear regression analysis
    Introduction to Primate Data Exploration and Linear Modeling with R was created with the goal of providing training to undergraduate biology students on data management and statistical analysis...

    Keywords: R programming languageprimatespopulation ecology

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    MS Excel Refresher - Lizards, iguanas, and snakes! Oh my! | Data Nuggets
    This resource, a MS Excel refresher, extends the level for this Data Nugget. Students are given an Excel workbook with the data and asked to graph and calculate diversity using Excel functions...

    Keywords: Resources @ Data NuggetsspreadsheetsRestoration EcologyUsing Excelgraphing in Excelformulas in ExcelApplied ecology

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    1-039-StochasticPopModels-ModelingScenario
    We develop strategies for creating a population model using some simple probabilistic assumptions. These assumptions lead to a system of differential equations for the probability that a system is...

    Keywords: Probabilitypopulation dynamicsVarianceMeanstochasticdeterministic

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    Design a Zoo (Grades 3-5)
    This classroom lesson presents students with the job of designing a zoo, which could include modeling tasks ranging from choosing and locating the exhibits to setting the right admission prices.

    Keywords: unit costbudgetsdistance

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    Module 2: Opening Your Eyes to the Diversity of Plants
    This activity picks up from Module 1 where students chose the plant they wanted to represent their botanical history. In that module, they each identified their plant’s family and were given its...

    Keywords: botanyPlant diversityLand plantsembryophytes

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    1986-Istvan_Gyori-Connections between compartment systems pipes and integro-differential equations
    In this paper we give the mathematical description of models in which the mass transport between compartments requires a given definite time or transit times are distributed according to given...

    Keywords: physiologypipelinecompartmentbloodcirculationintegro-differential equation

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    Piwi Matters
    This case focuses on understanding structure and function relationships in Piwi, a protein that is critical for germline stem cell function and development of eggs in the fruit fly ovary.

    Keywords: Stem cellsmolecular visualization and analysis3D protein structure /function analysisPiwiPDBMolecular Case Study

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    2007-Joseph_Myers-Brian_Winkel-Modeling_a_Mystery_Circuit_in_Mathematics_Class_Using_Differential_Equations_Laplace_Transforms_and_Transfer_Functions
    We discuss the introduction, student discovery, and teaching of a system of differential equations which model a circuit.

    Keywords: circuitLaplace transformtransfer functionmystery circuitvoltage frequencytwo loop circuit

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    Investigating human impacts on Southeastern US stream ecology using R
    Adaptation of the "Investigating human impacts on stream ecology: Scaling up from Local to National with a focus on the Southeast" specifically to focus on self-paced R code instruction
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    Spreadsheet Tutorial 1: Adapted to Anatomy and Physiology
    Adapted the examples to Anatomy and Physiology relevant topics and implemented in BIO165L Anatomy and Physiology I Laboratory for non-majors.

    Keywords: Resources @ HHMI - BioInteractivesummary statisticsScientific ProcessScientific Methodology

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    3-130-MatterOfSomeGravity-ModelingScenario
    This project introduces the concept of an inverse problem (or parameter estimation), in the context of the simple linearized pendulum ordinary differential equation.

    Keywords: gravityinverse problemacceleration

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    1999-F_Brauer-What Goes Up Must Come Down
    This paper is a wonderfully general analysis of the following, “It is natural to ask whether a particle propelled upwards takes longer to fall to earth from its maximum height than it takes to rise...

    Keywords: projectilefrictionfalling timerising timemaximum height

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