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Converting a Face-to-Face Lab to Online: An Example of Process and Outcomes for a CRISPR-Based Molecular Biology Lab
30 Aug 2021 | Teaching Materials | Contributor(s):
By Lisa M. McDonnell #*1, Keefe Reuther #1, Andrew Cooper1, Christopher Day1, Cindy Gustafson-Brown1
University of California, San Diego
The COVID-19 pandemic created a need to convert in-person laboratory courses into an online format in a short amount of time. For this reason, we converted our face-to-face molecular biology lab...
GMC: Genes, Mutations and Cancer - Group Concept Map Development
28 Aug 2021 | Teaching Materials | Contributor(s):
By Shoshana D. Katzman*1, John H. Horne2, Sonu S. Baral3, Keith P. Choe4, Elizabeth Eich5
1. Georgia Gwinnett College 2. University of New Orleans 3. Louisiana State University 4. University of Florida 5. Rice University
It has been shown that active learning strategies used in the classroom can increase student learning and retention of information. We generated an active learning exercise that can be used in the...
Linking Genotype to Phenotype: The Effect of a Mutation in Gibberellic Acid Production on Plant Germination
27 Aug 2021 | Teaching Materials | Contributor(s):
By James W. Mann1, Jennifer Larson2, Marcelo Pomeranz1, Emma M. Knee1, Diana Shin1, Julie A. Miller1, Courtney G. Price1, Deborah K. Crist1, Erich Grotewold1, Jelena Brkljacic1
1. The Ohio State University 2. Capital University
Basic concepts in genetics and plant development are often taught in lecture courses without a lab component. This approach provides students with the content knowledge, but fails to make...
A clicker-based case study that untangles student thinking about the processes in the central dogma
By Karen Nicole Pelletreau1, Tessa Andrews2, Norris Armstrong2, Mary A Bedell2, Farahad Dastoor1, Neta Dean3, Susan Erster3, Cori Fata-Hartley4, Nancy Guild5, Hamish Greig1, David Hall2, Jennifer K Knight5, Donna Koslowsky4, Paula Lemons2, Jennifer Martin5, Jill McCourt2, John Merrill4, Rosa Moscarella4, Ross Nehm3, Robert Northington1, Brian Olsen1, Luanna Prevost6, Jon Stolzfus4, Mark Urban-Lurain4, Michelle K. Smith1
1. University of Maine 2. University of Georgia 3. Stony Brook University 4. Michigan State University 5. University of Colorado Boulder 6. University of South Florida
The central dogma of biology is a foundational concept that provides a scaffold to understand how genetic information flows in biological systems. Despite its importance, undergraduate students...
Predicting and classifying effects of insertion and deletion mutations on protein coding regions
26 Aug 2021 | Teaching Materials | Contributor(s):
By Joseph Ross
California State University, Fresno
Mutations in genes can affect the encoded proteins in multiple ways, and some of these effects are counterintuitive. As for any other knowledge, students must create their own deep understanding of...
Happy Blue Baby
09 Jun 2021 | Teaching Materials | Contributor(s):
By Didem Vardar-Ulu
Boston University, Chemistry Department
This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved on its own...
Happy Blue Baby: MCQs for large classes
18 May 2021 | Teaching Materials | Contributor(s):
By "KP" Kristen Procko
Multiple choice questions for the Happy Blue Baby case study pre-work
CRISPR Gene Editing: Designing the gRNA and Donor Template
15 Jul 2020 | Teaching Materials | Contributor(s):
By Laurel Lorenz
In this adaptation, students learn how CRISPR/Cas9 is used in bacterial immunity and gene editing. Students create both a gRNA target and a donor template to edit a gene. Mutations can be from the...
The Happy Blue Baby Hemoglobin
14 Jun 2020 | Teaching Materials | Contributor(s):
By Kasandra Jean-Louise Riley1, Shuchismita Dutta2
1. Rollins College 2. RCSB Protein Data Bank, Rutgers University
This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved.
11 Jun 2020 | Teaching Materials | Contributor(s):
By Shuchismita Dutta
RCSB Protein Data Bank, Rutgers University
Exploring Random Mutation and Selection: Avida-Ed Lab Book Exercise 2
17 May 2020 | Teaching Materials | Contributor(s):
By Amy Lark, Cory Kohn1, Jim Smith1, Louise Mead2, Robert T Pennock1, Wendy Johnson
1. Michigan State University 2. BEACON Center for the Study of Evolution in Action
An introductory activity exploring the role of random mutation in natural selection using the Avida-ED simulation.
Exploring the Introduction of Genetic Variation by Random Mutation: Avida-Ed Lab Book Exercise 1
By Cory Kohn1, Amy Lark, Jim Smith2, Louise Mead3, Robert T Pennock2, Wendy Johnson
1. Keck Science Department, The Claremont Colleges 2. Michigan State University 3. BEACON Center for the Study of Evolution in Action
An introductory activity introducing the role of random mutation in generating genetic variation using the Avida-ED simulation.
Selection and the Blond Beach Mouse
12 Nov 2018 | Teaching Materials | Contributor(s):
By Joan Sharp
Simon Fraser University
National Center for Case Study Teaching in Science- this "clicker" case study explores ultimate and proximate explanations for cryptic coloration in animals.
Mutation and Selection: An Exploration of Antibiotic Resistance in Serratia Marcescens
25 Oct 2018 | Teaching Materials | Contributor(s):
By Laurel Hester1, Mark Sarvary2, Corey Ptak
1. Keuka College 2. Cornell University
This laboratory module gives students hands-on experience with mutation and selection in bacteria.
Joel E. Greengiant Learns About Peas: From Nucleotides to Selection
23 Oct 2018 | Teaching Materials | Contributor(s):
By Merle Heidemann1, Peter J.T. White1, Jim Smith1
Michigan State University
This case study follows purveyors of peas, Joel E. and Jolene Greengiant, as they learn about the origin, biochemistry, genetics and eventual artificial selection of sweet (wrinkled) peas, all in...
By Bob Sheehy
A Hardy-Weinberg simulation program.