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Regulation Across Scales: Data Points on How Life Works

By Kristine Grayson1, Kaitlin Bonner2, Alexandra Fairfield3, J. Phil Gibson4

1. University of Richmond 2. St. John Fisher College 3. Montgomery College, Takoma Park, MD 4. University of Oklahoma

We examined the scientific literature for simple, data-based illustrations of double-negative logic in the regulation of biological systems as described by Sean B. Carroll in his text, The Serengeti Rules.

Listed in Teaching Materials | resource by group HHMI BioInteractive

Version 1.0 - published on 02 Jan 2019 doi:10.25334/Q4T151 - cite this

Licensed under CC Attribution-NonCommercial-NoDerivatives 4.0 International according to these terms

General Rules of Regulation_Carroll.jpg


The Serengeti Rules by Sean B. Carroll (2016) describes how the principles of regulation operate across cellular, physiological, and ecological scales to govern the operation of biological systems. As a small working group, we collected examples of scientific studies with data-based figures that illustrated the principle of double-negative logic in regulation. Double-negative logic is described by Carroll as the indirect positive interaction between two components in a system, where the negative impact of component A on B and the negative impact of component B on C results in a positive indirect effect of A on C. 

After building a collection of studies, we developed data points (figure interpretation activities) for our classrooms that illustrated this principle. These have been organized as individual adaptions of this central investigative work. 


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