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    Instructor Guide: Integrating Project Leadership, Artificial Intelligence, Simulation and Google Tools to Understand Regulation of Gene Expression with the Lac Operon and Lactase Gene
    Scientific leadership and current artificial intelligence (AI) skills are important skills to be included in the course curriculum. Together or individually, these skills can enhance knowledge,...

    Keywords: Resources @ HHMI - BioInteractivebiologymolecular biologygenomicsArtificial Intelligencegene expressionleadershipgroup worklactosegoogle toolsSeniorPhET SimulationLactase

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    GEA Introductory lesson on RNA-Seq
    This RNA-Seq lesson uses the CyVerse VICE Platform and Jupyter notebooks to examine the expression of the leptin gene in samples from a mouse experimental design evaluating diet (high-fat vs....

    Keywords: data sciencebioinformaticsGenome BrowserRNAseqhigh throughput sequencingmRNAAlignmentNCBI Sequence Read Archive

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    Using Undergraduate Molecular Biology Labs to Discover Targets of miRNAs in Humans
    In this lesson, we describe an easily adaptable lab module that can be used in existing undergraduate molecular biology lab courses to conduct authentic scientific research, published in CourseSource

    Keywords: molecular biologybioinformaticsNIBLSEgene regulationmicroRNAsgene expressionCourseSourcemiRNA

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    Build Multiomic and Visualization Skills in Bioscience Lecture
    This resource promotes inclusive learning by using all free platforms to extend the central dogma to an applied experience. Genomics is focused on with literature reviews that are performed to...

    Keywords: geneticsBiochemistryBiology and Biochemistry EduationProtein StructureBioinformatics and GenomicsFunctional GenomicstranscriptomicsproteomicsRNAseqClinical genomicsprotein structure modelingInclusive teaching3D protein structure /function analysisinclusive classrooms3D protein structuresinclusivegene

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    The Evolution of Color Vision in Monkeys: From Nucleotides to Ecology
    This case study examines the evolution color vision in Old World and New World monkeys from multiple biological perspectives.

    Keywords: phylogeneticsgenescase studybiologyResources @ NSF - NCCSTSColor visiondichromatictrichromaticnucleotidesproteinsopsinscell functioncone cellsphotoreceptorsspectral shiftgene duplicationmeiosissex-linkedfood gatheringmonkeysprimatesResources @ QUBES - Teaching & Referenceundergraduate biology education

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    Learn biotechnology, biophysics and business through scientific thinking and innovation
    Scientific, leadership and innovation skills are also an integral framework of the curriculum. All of them together or individually are important for enhancement of knowledge, critical thinking,...

    Keywords: educationbusinessBiotechnologybiophysicsleadershiprecombinant DNAgroup workcloninginnovationscientific thinkingplasmid

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    Joel E. Greengiant Learns About Peas: From Nucleotides to Selection
    This case study follows purveyors of peas, Joel E. and Jolene Greengiant, as they learn about the origin, biochemistry, genetics and eventual artificial selection of sweet (wrinkled) peas, all in...

    Keywords: geneticspopulation geneticsEvolutionintroductory biologycase studybiologyResources @ NSF - NCCSTSmeiosisMendel’s peaspea plantPisum sativumMendel’s Lawsmolecular geneticsmutationnucleotide insertionartificial selectionstarch synthesisstarch branching enzymeplant domesticationlegumesResources @ QUBES - Teaching & Reference

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    Louse Genetics, Genomics, and Gene Function...Oh My!
    In this module, students will be investigating a louse gene with an unknown function to determine if it might be important in the evolution of the louse ecomorphs.

    Keywords: parasitesgenomicsgene sequence analysisFunctional Genomics

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    Neochromosomes: Creating transcriptional units with yeast Golden Gate assembly
    This resource is a series of protocols using the yeast Golden Gate (yGG) method as developed by Neta Agmon and Leslie Mitchell in Jef Boeke’s lab to assemble a functional yeast gene with...
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    Drug screening and cancer resistance: EGFR Activity
    This activity explores a specific gene (egfr) and its role in cancer. EGFR was introduced with the Gene Card Activities, researched throughout the semester, and then authentic image data of...

    Keywords: Resources @ HHMI - BioInteractivegenomicscancergenetic basis of diseasebiology of cells

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    Yeast Scramble Lab Manual v3
    This laboratory manual includes protocols for SCRaMbling of yeast cells as well as phenotypic characterization. Appropriate student exercises are also included. This resource was developed as part...
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    Yeast Scramble Lab Manual
    This laboratory manual includes protocols for SCRaMbling of yeast cells as well as phenotypic characterization. Appropriate student exercises are also included. This resource was developed as part...
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    CRISPR Gene Editing: Designing the gRNA and Donor Template
    In this adaptation, students learn how CRISPR/Cas9 is used in bacterial immunity and gene editing. Students create both a gRNA target and a donor template to edit a gene. Mutations can be from the...

    Keywords: geneticseducationcell biologymolecular biologymutationStem cellsstructure-functionmolecular visualization and analysis3D protein structure /function analysisCRISPR/Cas9crisprDNA mutationPiwiPDBMolecular Case StudyPiwi Matters

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    The Human Microbiome Biodiversity in Health and Disease
    The students will analyze the human gut and vaginal microbiomes in healthy and diseased states using diversity of bacteria as determined by 16SrRNA sequence.
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    Build-a-Genome Lab Manual for RFP Synthesis
    This lab manual describes a multi-week lab project for the design, assembly from oliognucleotides, cloning, and sequencing of the RFP gene. This resource was developed as part of NSF Award...
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    A Hands-on Introduction to Hidden Markov Models
    A lesson in which students will understand the basic structure of an HMM, the types of data used in ab initio gene prediction, and its consequent limitations.

    Keywords: Markov modelbioinformaticsgenomicsNIBLSEtranscriptionCourseSourceexonintronsplicing

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    Effect of the Intestinal Protein Snakeskin on the Lifespan of Fruit Flies: A Kaplan-Meier Survival Analysissource Draft (1)
    In this activity, students perform the Kaplan-Meier survival analysis on raw data obtained from an experiment that explores the effect of overexpressing the Snakeskin (Ssk) protein on the lifespan...

    Keywords: graphingBiochemistryhypothesis testingcalculus and biologyapproximating areas under curvesqbccCellular and Molecular BiologyCreate graphsInterpret graphsSolving Equations and Inequalitiesinterpret tablesConcepts in Statisticsusing statisticschi-square analysissurvival analysis

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    Genome Solver - A bioinformatics pipeline for community science
    The Genome Solver was an NSF-funded project developed as a way to train undergraduate life science faculty in basic web-based tools for bioinformatics. As part of the project we developed a one-day...

    Keywords: phylogeneticsbacteriophagebacteriaHorizontal Gene transferGenome Analysis

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    Learn genomics and bioinformatics through scientific thinking, creation and analysis (virtual and hands-on)
    Nucleic acid are biological molecules composed of nitrogen-containing bases, phosphate groups, and sugar molecules. The complimentary chemical bonding results in formation of double stranded DNA....

    Keywords: data analysisbioinformaticsnucleotidesproteinsRNAgenomicsScientific communicationscientific writingDNAmodelling scientific thinkinggenescientific thinkingcreation

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    Teaching Protein Structure Modeling
    New strains of microbes have been regularly discovered and brought into a laboratory for study in many different directions. When a new microbial genome is sequenced and assembled, the homologues...

    Keywords: Microbiology Educationbioinformaticsprotein structure modeling

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