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    Maria vs Malaria
    This case study focuses on a specific enzyme Lactate Dehydrogenase (LDH) in the malarial parasite as a target for treating malaria.

    Keywords: bioinformaticsmolecular visualizationstructure-functionuniprotProtein Data BankMolecular Case StudyMolecular CaseNet

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    Making “sense” out of surface area to volume relationships
    Using a multimodal approach, the non-linear aspect of the surface area to volume relationship is explored. Students use their their senses of taste and sight to determine how smaller cells and...

    Keywords: active learningintroductory biologycell biologyquantitative skillskinesthetic learningLDC2023

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    CRISPR Gene Editing: Designing the gRNA and Donor Template
    In this adaptation, students learn how CRISPR/Cas9 is used in bacterial immunity and gene editing. Students create both a gRNA target and a donor template to edit a gene. Mutations can be from the...

    Keywords: geneticseducationcell biologymolecular biologymutationStem cellsstructure-functionmolecular visualization and analysis3D protein structure /function analysisCRISPR/Cas9crisprDNA mutationPiwiPDBMolecular Case StudyPiwi Matters

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    Homologous chromosomes? Exploring human sex chromosomes, sex determination and sex reversal using bioinformatics approaches
    In this four- part guided activity, students will learn about the structure and function of human autosomal and sex chromosomes, view and interpret gene maps, and gain familiarity with basic...

    Keywords: bioinformaticsNIBLSECourseSourceautosomehomologous chromosomeshomologous recombinationsex chromosomesex determinationsex reversal mutations

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    Cystic Fibrosis Mechanism and Treatment
    This animation shows how mutations in an ion channel protein lead to the genetic disease cystic fibrosis. The animation also discusses how research on this protein has been used to develop...

    Keywords: Resources @ HHMI - BioInteractiveBiochemistrymacromoleculesGenetic diseaseCell Structure & Function

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    Introduction to Genome Annotation
    This exercise is an adaptation of the Annotation Lesson by Rosenwald et al. It introduces the use of bioinformatics tools to extract information from genome databases. It is a basic lesson on...

    Keywords: microbiologyGenome annotationBioinformatics EducationBioinformatics and Genomics

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    The p53 Gene and Cancer
    This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer.

    Keywords: Resources @ HHMI - BioInteractiveBiochemistrymolecular biologymacromoleculesGenetic disease

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    Build Multiomic and Visualization Skills in Bioscience Lecture
    This resource promotes inclusive learning by using all free platforms to extend the central dogma to an applied experience. Genomics is focused on with literature reviews that are performed to...

    Keywords: geneticsBiochemistryBiology and Biochemistry EduationProtein StructureBioinformatics and GenomicsFunctional GenomicstranscriptomicsproteomicsRNAseqClinical genomicsprotein structure modelingInclusive teaching3D protein structure /function analysisinclusive classrooms3D protein structuresinclusivegene

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    Maria vs Malaria - AR Adaptation
    This case study focuses on a specific enzyme Lactate Dehydrogenase (LDH) in the malarial parasite as a target for treating malaria. Students will be able to view selected molecular views from the...

    Keywords: bioinformaticsAugmented RealityLarge class sizemolecular visualizationstructure-functionuniprotProtein Data BankMolecular Case StudyMolecular CaseNet

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    Kinetics of a Highly Conserved Enzyme - Carbonic Anhydrase
    This module contains exercises designed to introduce students to graphical representation of biological data. Students will explore the fundamental principles of enzyme kinetics including...

    Keywords: Excelintroductory biologycell biologygraphingslopeQuantitative reasoningdata visualizationquantitative biologyinterdisciplaryquantitative skillscorrelationenzyme functionInterpreting GraphsMichaelis-Mentenenzyme kineticsEnzyme activityenzyme inhibitionLinear and nonlinear analysisNIQBC2. Data and GraphsC4. mathematical modelsenzyme-substrateNIQB Interdisciplinary Quantitative Reasoningcarbonic anhydrase

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    Using: "Winter Is Coming! Can you Handle the Freeze?" In an Intro BIO lecture
    I use Team Based Learning in this course, students are in permanent groups and work together on Challenge Questions each class after I give a short lecture. This Nugget was used in place of regular...

    Keywords: graphing

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    Cellular Respiration and pH: blocking the electron transport chain and its effects on the proton gradient, pH, and ATP production
    This module contains exercises designed to help students describe the stages of cellular respiration and quantify the energy molecules produced. Students will predict the region of higher proton...

    Keywords: introductory biologyQuantitative reasoningquantitative biologyinterdisciplarycell functionInterpreting GraphsATPpHCellular RespirationEnergy transformationsElectron flowNIQBC2. Data and GraphsC4. mathematical modelsC1. Numeracyproton gradientelectron transportelectron transport blockersFADH2chemiosmosisATP synthaseNADHproton concentration

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    Sizes, Scales and Specialization: Using Relative Proportions and Scientific Notation to Highlight the Diversity of Cell Types
    This module explores how cell size and shape varies across cell types in the human body by having students calculate relative proportions of numbers in scientific notation.

    Keywords: ExponentsRatiosCellsqbccmanipulate equationsCellular and Molecular BiologyVisual Accommodationsconverting unitschanging scales

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    Collaborative case writing and field testing with Molecular CaseNet brings together discipline specific expertise for innovative pedagogical tools in the classroom
    Molecular case studies (MCS) use an interesting story as a hook , followed by exploration of biochemistry of one or more molecules of interest.  They can be useful in teaching about macromolecule...
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    Nature’s Flying Machines: The Evolutionary Relationship of Avian Form & Function
    In this series of activities, birds will be used as the model organism. The modules examine the connections between body form and function over time by investigating the relationship between avian...

    Keywords: evolutionary ecologyCommunity Ecology

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    Macromolecular math
    This worksheet was developed for use in an introductory biology course to review the chemical bonds and structure of biological macromolecules. A nutritional label is provided to illustrate that...

    Keywords: introductory biologycarbohydratesProtein StructureNucleic Acid Structuremacromoleculesnon-covalent interactionpolypeptidechemical bonds

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    When tests disagree, how do I know if I have COVID-19?
    Students will learn about infectious disease and the immune response to infection by investigating different types of tests (PCR, antigen, and antibody tests) to detect the SARS-CoV-2 viral genetic...

    Keywords: geneticsVision and Changeintroductory biologyinfectious diseasemolecular biologycore competenciesRT-PCRviruscore conceptsnon-majors biologySARS-CoV-2antibodyAntigenImmunoReachmolecular DiagnosticsCOVID-19 transmission

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    Operon
    This Excel workbook models lac operon function in a partial diploid E. coli. The user chooses the bacterial genotype and the sugars present in the surrounding medium: the workbook then determines...

    Keywords: Lac OperonE. coli

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    Box-of-Lessons Review, Fall 2022 - YouTube
    This video described the working group activities for BIOME Institute 2022 - Fall working group

    Keywords: carbohydratesproteinsNucleic Acid Structurebiomolecular structurebiomolecular visualizationProtein Data Bankresources @ Molecular CaseNetBIOME 2022pilotinglipidsbiomolecules

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    Climate Change Effects on Lake Temperatures (Project EDDIE)
    Students explore new modeling and computing tools while learning fundamental concepts about how climate change will affect lakes

    Keywords: climate changeProject EDDIElakes

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