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    BSL-4: Authorized Personnel Only
    National Center for Case Study Teaching in Science resource on the 2014 Ebola epidemic. This resource is also included in the NIBLSE Learning Resource Collection

    Keywords: infectious diseaseexperimental designbioinformaticsEbolaNIBLSECase It!PCRBLASTmultiple sequence alignmentPublished in National Center for Case Study Teaching in Sciencepolymerase chain reactionfebrile illnessvirusELISAenzyme linked immunosorbent assayfilovirusAfrica

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    Yeti or not: Do they exist?
    Through this 4-part bioinformatics case study, students will be led through the forensic analysis of putative Yeti artifacts based on published findings.

    Keywords: case studybioinformaticsNIBLSEBLAST12S sequencingYeti

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    Prosecutor’s Fallacy and Mammograms Case Study
    An introduction to Prosecutor’s Fallacy, and False Positives/Negatives. By Dr. Diaz Eaton, Bates College, for use in DCS 105A, and inspired by Calling Bull & Calculated Risks.

    Keywords: ProbabilityExcelcalling bullMammogramsData UnderstandingVisualizing Outcomes

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    CRISPR Gene Editing: Designing the gRNA and Donor Template
    In this adaptation, students learn how CRISPR/Cas9 is used in bacterial immunity and gene editing. Students create both a gRNA target and a donor template to edit a gene. Mutations can be from the...

    Keywords: geneticseducationcell biologymolecular biologymutationStem cellsstructure-functionmolecular visualization and analysis3D protein structure /function analysisCRISPR/Cas9crisprDNA mutationPiwiPDBMolecular Case StudyPiwi Matters

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    Adaptation of Terrestrial Trophic Cascades & Population Structure to a Non-Major’s Ecology Course
    In this activity, students will use data from natural parks to examine trophic cascades.

    Keywords: case studyBiodiversityplantsResource Typetrophic cascadesnational parks

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    Advanced Student Molecular Case Study Authorship Scaffolded Project and Rubric
    Instructions, assignment prompts, and a rubric for assessing advanced undergraduate authorship of molecular case studies
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    Investigating the ecological value of migratory fishes on stream ecosystems in southern Appalachia
    Using the Ecological Society of America’s Four-Dimensional Ecology Education (4DEE) framework, students apply ecological concepts such as energy flow, nutrient cycling, migration, and climate...

    Keywords: Stream ecologynutrient cycling4DEE Frameworkfish migration

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    COVID-19: On the way to a vaccine
    This multi-part case study introduces the reader to the SARS-CoV-2 virus origins, the molecular basis of the infection, the development and severity of symptoms, and treatment.

    Keywords: BLASTprotein structure modelingmolecular visualization and analysisCOVID19PDB

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    Understanding COVID-19 Biology to Design a Vaccine
    This multi-part case study introduces the reader to the SARS-CoV-2 virus, replication, and treatment. Additional worksheets introduce students to bioinformatics tools of 3-D protein visualization...

    Keywords: BLASTprotein structure modelingmolecular visualization and analysisCOVID19PDB

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    Molecular Basis of Sickle Cell Disease
    This multi part case on hemoglobin structure as it relates to oxygen binding and sickle cell disease focuses on utilizing bioinformatics and molecular visualization tools to learn about the sickle...

    Keywords: Hemoglobinmolecular visualization and analysisintroductory bioinformaticssickle cell diseasePDBMolecular Case Studyoxygen bindingmyoglobinmolecular literacy3D protein structuresstructural representations

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    Exploring the population dynamics of wintering bald eagles through long-term data using R
    The purpose of this modification was to take the analyses that were done in Excel and have the students perform them using R. Students were not given any R code for this activity, as R code was...

    Keywords: Resources @ ESA - TIEEcase studyR programming languagepopulation ecologyendangered speciesconservation biologymigration ecologyggplot2

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    Modified Grassy Narrows and Muskrat Falls Dam: Hypothesis Testing and t-Tests
    Methylmercury contamination within fish populations is an important toxin that affect human, animal, and environmental health, serving as a carcinogen (cancer-causing agent) and endocrine-disruptor...

    Keywords: statisticsmathematicsbiostatisticsecologybiologygraphingp-valuest-testshypothesis testingin-class activityZoologymercury biogeochemistrybiostatistics - generalfish populationqbccEndocrine DisruptorsBiogeochemical cyclesInterpret graphsSolving Equations and InequalitiesConcepts in StatisticsElementary Hypothesis TestingMethylmercurydamsBioaccumulationtraditional dietsmercurymercury poisoningnative peopleindigenous populationCanadahydroelectricexplaining statisticsusing statisticsMake probability calculationsbiomagnification

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    Grassy Narrows and Muskrat Falls Dam: Hypothesis Testing and t-Tests
    Students are introduced to concepts of hypothesis testing using elementary hypothesis tests, t-tests, and p-values as they compare a given fish population for methylmercury levels (using real and...

    Keywords: statisticsmathematicsbiostatisticsecologybiologygraphingp-valuest-testshypothesis testingin-class activityZoologymercury biogeochemistrybiostatistics - generalfish populationqbccBiogeochemical cyclesInterpret graphsSolving Equations and InequalitiesConcepts in StatisticsElementary Hypothesis TestingMethylmercurydamsBioaccumulationtraditional dietsmercurymercury poisoningnative peopleindigenous populationCanadahydroelectricexplaining statisticsusing statisticsMake probability calculations

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    Remote sensing data processing – NEON airborne data
    Concepts of remote sensing and data logistics, and NEON remote sensing data are introduced. Students learn how to apply spatial data processing and visualization skills using R coding program to...

    Keywords: RlandscapebiomassProblem Solvingraster raster data processingspatial data visualizationvegetation indicescanopy

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    The River Breathes: Stream reach metabolism as an integrative and comparable measure of stream processes
    Stream reach metabolism integrates organism respiration & production to provide a valuable ecosystem measure that varies as a function of biotic & abiotic factors. As a powerful indicator of whole...

    Keywords: ecosystem respirationMetabolismriverRespirationproductionRiver Field Studies NetworkDissolved OxygenStream MetabolismEcosystem ProductionStreamField LessonGuided Student ReflectionStudent Reflection

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    Grassy Narrows and Muskrat Falls Dam: The Central Limit Theorem and a t-test
    Students are introduced to concepts of sampling distributions and hypothesis testing using a simulation applet, elementary hypothesis tests, t-tests, and p-values as they compare a given fish...

    Keywords: statisticsmathematicsbiostatisticsecologybiologygraphingp-valuest-testshypothesis testingin-class activityZoologymercury biogeochemistrybiostatistics - generalfish populationqbccBiogeochemical cyclesInterpret graphsSolving Equations and InequalitiesConcepts in StatisticsElementary Hypothesis TestingMethylmercurydamsBioaccumulationtraditional dietsmercurymercury poisoningnative peopleindigenous populationCanadahydroelectricexplaining statisticsusing statisticsMake probability calculations

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    Leaf litter and soil invertebrates
    The diversity of invertebrates occupying the leaf litter and organic layer of soil can be quantified to examine abiotic and biotic questions. This lab can be used as a starting point for a...
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    DCS 105 Calling Bull F24 Schedule
    Schedule overview for Bates College Course DCS 105 Calling Bull

    Keywords: datacalling bullmisinformationBates CollegeSchedule

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    Ecology of Infectious Disease: Data Mining the National Notifiable Diseases Surveillance System (NNDSS) for Ecological Patterns
    How to use publicly available infection case data to teach ecology and evolution of human infectious diseases.

    Keywords: Evolutionecologyinfectious diseasehumansjigsawsmall group workEvolutionary medicinedata explorationCDCNNDSS

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    Exploring Coyote Morphology: Introduction to Research and Study Design
    This module is designed as a first foray for freshman-level (novice undergraduate) students into science literacy, research design, and use of museum resources in research activities. The module...

    Keywords: statisticsnatural history museumsdistance learningscience literacyStudy Designintraspecific variation

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