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The QUBES platform hosts hundreds of teaching materials, reference materials, and cloud-based software free to use and adapt using open Creative Commons licenses.

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    2017-D_Goulet-Modeling, Simulating, and Parameter Fitting of Biochemical Kinetic Experiments
    In many chemical and biological applications, systems of differential equations containing unknown parameters are used to explain empirical observations and experimental data. The differential...

    Keywords: optimizationBiochemistrysensitivity analysischromatographymass actioncluster analysisconservation lawsdimerizationestrogen receptor protein

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    A Critical Guide to the PDB
    This Critical Guide in the Introduction to Bioinformatics series provides a brief outline of the Protein Data Bank – the PDB – the world’s primary repository of biological macromolecular structures.

    Keywords: NIBLSEGOBLETInstructorResources

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    Understanding Frameshifting
    This module contains activities to help students understand the biology of programmed translational frameshifts (PTFs) in phages, how to identify PTFs, and how to annotate them.
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    BLAST-HGT PROJECT
    Genome Solver modules were combined to make one project for students using tools within NCBI BLAST to explore phylogenetics and horizontal gene transfer from phage to Chlamydia.
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    ProteinPhysiochemistry
    How to determine physiochemical features of proteins using ExPasy Protpram, SOSUI server, and PSortB programs.

    Keywords: videosbioinformaticsproteinsgenomicsyoutubeprotein physiochemistryExPasy ProtpramSOSUI serverPSortB

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    Using Phyre2
    How to use Phrye2 and 3DLigandSite to computationally predict protein and active site structure and binding partners (substrates/cofactors/coenzymes).

    Keywords: videosbioinformaticsproteinsgenomicsyoutubephyre23DLigandSite

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    Understanding Protein Domains: A Modular Approach
    An understanding of protein structure, function, and interaction is central to biochemistry. One angle into this topic is to engage students in considering protein domains as modules that develop...

    Keywords: Protein Structure

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    Learn Biological Sciences and Physics through scientific process, creation, experimentation and analysis
    Microbes remain attached and grow on various surfaces whether living or non-living. These surfaces provide differential growth substances for microbes to remain attached or grow. The differential...

    Keywords: data analysisscientific methodphysicshands-onScientific InquirymicrobesBiological SciencesSpectrophotometer

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    GSD QUBES Resource Draft (1)
    This QUBES module is focused towards AP Environmental studies courses. It includes hypothesis testing, transect sampling, Shannon Diversity Index, and scatter plot and bar graph creation in excel.

    Keywords: Community EcologyField researchspidersMicrosoft ExcelShannon diversity index

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    Investigating human impacts on stream ecology: Intro to R
    This resource uses the Human Impact on Stream Ecology data set, background and questions and provides students an very general introduction to using R. Students perform basic summary statistics and...

    Keywords: graphingdata visualizationR programming languagedescriptive statisticsundergraduate environmental science

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    Learn genomics and bioinformatics through scientific thinking, creation and analysis (virtual and hands-on)
    Nucleic acid are biological molecules composed of nitrogen-containing bases, phosphate groups, and sugar molecules. The complimentary chemical bonding results in formation of double stranded DNA....

    Keywords: data analysisbioinformaticsnucleotidesproteinsRNAgenomicsScientific communicationscientific writingDNAmodelling scientific thinkinggenescientific thinkingcreation

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    Investigation of Subunit Interactions of Glyoxysomal Malate Dehydrogenase Using Engineered Cysteine Residues
    A research poster.

    Keywords: JoCURE

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    Wenxiang 3.0
    Wenxiang diagrams illustrate protein helices as spirals on a plane and thus have the advantage over helical wheels of being planar graphs. Wenxiang 3.0 extends the original version by adding...
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    Wenxiang 3.0
    Wenxiang diagrams illustrate protein helices as spirals on a plane and thus have the advantage over helical wheels of being planar graphs. Wenxiang 3.0 extends the original version by adding...

    Keywords: bioinformaticsproteinsWenxiang

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    Wenxiang 3.0
    Wenxiang diagrams illustrate protein helices as spirals on a plane and thus have the advantage over helical wheels of being planar graphs. Wenxiang 3.0 extends the original version by adding...

    Keywords: bioinformaticsproteinsWenxiang

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    Neochromosomes: Creating transcriptional units with yeast Golden Gate assembly
    This resource is a series of protocols using the yeast Golden Gate (yGG) method as developed by Neta Agmon and Leslie Mitchell in Jef Boeke’s lab to assemble a functional yeast gene with...
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    Intro videos and terminology for GMOs, Transcription, Translation
    Compiled resources around GMOs and protein production including vocabulary, animations, videos, and games

    Keywords: geneticsagricultureplantstranscriptiongenomesGMOtranslation

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    The p53 Gene and Cancer
    This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer.

    Keywords: Resources @ HHMI - BioInteractiveBiochemistrymolecular biologymacromoleculesGenetic disease

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    Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes
    Students require a deep understanding of the central dogma before they can understand complex topics such as evolution and biochemical disorders. However, getting undergraduate biology students to...

    Keywords: Protein Structurecomputational modelingcentral dogmaplant leaf structurePhenotype/Genotype

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    Investigating the Function of a Transport Protein: Where is ABCB6 Located in Human Cells?
    One of the challenges of teaching Cell Biology is helping students understand important research methods used to study cells.  The goal of understanding cell biology methods is especially...

    Keywords: ABC transporter familyDifferential centrifugationImmunoblottingImmunofluorescence assayProtein localizationPurifying organellesSDS-PAGE

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