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    Linked Genes and Recombination: Advanced Punnett Squares
    An online module in which students learn about more difficult genetics problems, including linked genes and crossing over. Quantitatively students learn about marginal probabilities and chi-square...

    Keywords: geneticsProbabilityResources @ MathBenchonlinepunnett squareslinked genes

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    Chi-Square analysis of two point test cross data
    This flash tutorial simulates analysis of a 2 point test cross and will walk you through the analysis of two hypothetical traits.

    Keywords: geneticssimulationchi-squaredlinkagetest crossrecombinationdemonstrationin-class activityproblem set

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    Module 6: Alternative Splicing
    This module explores how multiple different mRNAs and polypeptides can be encoded by the same gene. After completing this module students will be able to explain how alternative splicing of a gene...

    Keywords: geneticsdata visualizationmolecular biologygenomicsexonintronalternative splicingSimilarity searchesMessenger RNA

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    Why do Some People Inherit a Predisposition to Cancer? A small group activity on cancer genetics
    Before undergraduate students take a genetics course they generally know cancer has a genetic basis and involves the proliferation of cells; however, many are uncertain about why only a subset of...

    Keywords: cancerInheritance patternsProbability calculationProto-oncogeneTumor Suppressor Gene

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    Fruit Fly Genetics in a Day: A Guided Exploration to Help Many Large Sections of Beginning Students Uncover the Secrets of Sex-linked Inheritance
    Moving beyond the basic concepts of autosomal Mendelian inheritance to sex-linkage can be difficult for introductory biology students. Although crosses with Drosophila fruit flies have long been a...

    Keywords: Mendelian Geneticsfruit fly biologysex-linked inheritance

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    The Evolution of Color Vision in Monkeys: From Nucleotides to Ecology
    This case study examines the evolution color vision in Old World and New World monkeys from multiple biological perspectives.

    Keywords: phylogeneticsgenescase studybiologyResources @ NSF - NCCSTSColor visiondichromatictrichromaticnucleotidesproteinsopsinscell functioncone cellsphotoreceptorsspectral shiftgene duplicationmeiosissex-linkedfood gatheringmonkeysprimatesResources @ QUBES - Teaching & Referenceundergraduate biology education

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    Homologous chromosomes? Exploring human sex chromosomes, sex determination and sex reversal using bioinformatics approaches
    Constructing a robust understanding of homologous chromosomes, sex chromosomes, and the particulate nature of genes is a notoriously difficult task for undergraduate biology students. In this...

    Keywords: bioinformaticsautosomehomologous chromosomeshomologous recombinationsex chromosomesex determinationsex reversal mutations

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    A Muscular Dystrophy Case Study Illustrating the Phenotypic Effects of Mutation
    Mutations in genes can lead to a variety of phenotypes, including various human diseases. Students often understand that a particular mutation in a single gene causes a disease phenotype, but it is...

    Keywords: mutationProtein Structureethicscentral dogmahuman disease

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    X-ploring Fragile X: The Science Behind the Syndrome
    Fragile X Syndrome is an X-linked genetic disorder resulting from the impairment of transcription of the FMR1 gene, producing less to no FMRP protein. FMRP is a translational inhibitor that plays a...

    Keywords: epigeneticsgene regulationtranscriptioncentral dogmatranslationFragile X syndromeSphingosine Metabolism

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    Understanding Eukaryotic Genes modules: Glossary of terms
    This glossary defines the key terms that are used in the Understanding Eukaryotic Genes modules.

    Keywords: geneticsmolecular biologygenomicsGlossary

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    Teaching Genetic Linkage and Recombination through Mapping with Molecular Markers
    Most introductory genetics courses cover genetic linkage, a core concept in the CourseSource genetics learning outcome framework. Although it is a classical genetics topic, genetic linkage remains...

    Keywords: meiosisphenotypegel electrophoresismicrosatellitesBanding PatternGenetic linkageInheritanceMolecular MarkersPhysical Linkage

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    Antibiotic Resistance Genes Detection in Environmental Samples
    Our aim is to provide an authentic research experience for undergraduate students in a variety of biology courses through collaboration between a four-year university and a community college. This...

    Keywords: geneticsenvironmentmicrobiologyUndergraduateantibiotic-resistancePCRgel electrophoresisauthentic inquiry

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    RNA-seq Analysis
    In this computer lab module, students learn how to process an RNA-seq data set to identify differentially expressed genes (DEGs). The samples for this data set were collected from yeast cells...

    Keywords: LabRNAsequencingUndergraduateNIBLSEincubatorsRNAseqInstructional SettingAudience LevelActivity LengthMore than 1 hourC4. Bioinformatics toolsC5. Data retrievalReviewed at NIBLSEdifferentially expressed genes

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    Investigating Cell Signaling with Gene Expression Datasets
    Modern molecular biology is a data- and computationally-intensive field with few instructional resources for introducing undergraduate students to the requisite skills and techniques for analyzing...

    Keywords: genomicstranscriptionsignaling

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    Introduction to Genome Browser: What is a Gene?
    In this module, we will use a web-based visualization tool called a Genome Browser to explore the structure of a eukaryotic gene, and obtain a basic understanding of how this information is...
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    Operon
    This Excel workbook models lac operon function in a partial diploid E. coli. The user chooses the bacterial genotype and the sugars present in the surrounding medium: the workbook then determines...

    Keywords: Lac OperonE. coli

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    RNAseq data analysis using Galaxy
    This is a bioinformatics exercise intended for use in a computer lab setting with life science majors.

    Keywords: LabbioinformaticsNCBImappingUndergraduateworkflowNIBLSEGalaxyRNAseqgene expressionAdvancedExtended ProjectArabidopsisC1. Role of bioinformaticsC2. Computational conceptsC3. Statistical conceptsC5. Data retrievalIncubated at NIBLSEdifferentially expressed genes

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    Lesson VII - Synteny
    The lesson teaches about synteny or the order of genes along a chromosome, which is useful for looking at orthologous genes between two species or strains.

    Keywords: Bioinformatics Education

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    Lesson III - Annotation
    Genome Solver began as a way to teach undergraduate faculty some basic skills in bioinformatics; no coding or scripting is required. Lesson III introduces Annotation, or assigning meaning to all...
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    Lesson III - Annotation
    Genome Solver began as a way to teach undergraduate faculty some basic skills in bioinformatics; no coding or scripting is required. Lesson III introduces Annotation, or assigning meaning to all...
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